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Statins: the next step in adjuvant therapy for sepsis?

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References

  1. Kumana CR, Cheung BM, Lauder IJ (2003) Simvastatin reduced mortality and vascular events in high-risk patients. ACP J Club 138:2–3

    PubMed  Google Scholar 

  2. The Scandinavian Simvastatin Survival Study (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease. Lancet 344:1383–9

    PubMed  Google Scholar 

  3. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group (1998) Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 339:1349–57

    Article  PubMed  Google Scholar 

  4. Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360:7–22

    Article  PubMed  Google Scholar 

  5. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O’Brien E, Ostergren J (2003) Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 361:1149–1158

    Article  PubMed  Google Scholar 

  6. Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, Joyal SV, Hill KA, Pfeffer MA, Skene AM (2004) Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 350:1495–1504

    Article  PubMed  Google Scholar 

  7. Chan KY, Boucher ES, Gandhi PJ, Silva MA (2004) HMG-CoA reductase inhibitors for lowering elevated levels of C-reactive protein. Am J Health Syst Pharm 61:1676–1681

    PubMed  Google Scholar 

  8. Arnaud C,Mach F (2005) Pleiotropic effects of statins in atherosclerosis: role on endothelial function, inflammation and immunomodulation. Arch Mal Coeur Vaiss 98:661–666

    PubMed  Google Scholar 

  9. Kleemann R, Verschuren L, de Rooij BJ, Lindeman J, de Maat MM, Szalai AJ, Princen HM, Kooistra T (2004) Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. Blood 103:4188–4194

    Article  PubMed  Google Scholar 

  10. Hernandez-Presa MA, Ortego M, Tunon J, Martin-Ventura JL, Mas S, Blanco-Colio LM, Aparicio C, Ortega L, Gomez-Gerique J, Vivanco F, Egido J (2003) Simvastatin reduces NF-kappaB activity in peripheral mononuclear and in plaque cells of rabbit atheroma more markedly than lipid lowering diet. Cardiovasc Res 57:168–177

    Article  PubMed  Google Scholar 

  11. Diomede L, Albani D, Sottocorno M, Donati MB, Bianchi M, Fruscella P, Salmona M (2001) In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. Arterioscler Thromb Vasc Biol 21:1327–1332

    PubMed  Google Scholar 

  12. Steiner S, Speidl WS, Pleiner J, Seidinger D, Zorn G, Kaun C, Wojta J, Huber K, Minar E, Wolzt M, Kopp CW (2005) Simvastatin blunts endotoxin-induced tissue factor in vivo. Circulation 111:1841–1846

    Article  PubMed  Google Scholar 

  13. Krysiak R, Okopien B, Herman Z (2003) Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes. Drugs 63:1821–1854

    PubMed  Google Scholar 

  14. Shi J, Wang J, Zheng H, Ling W, Joseph J, Li D, Mehta JL, Ponnappan U, Lin P, Fink LM, Hauer-Jensen M (2003) Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. Blood Coagul Fibrinolysis 14:575–585

    Article  PubMed  Google Scholar 

  15. Pleiner J, Schaller G, Mittermayer F, Zorn S, Marsik C, Polterauer S, Kapiotis S, Wolzt M (2004) Simvastatin prevents vascular hyporeactivity during inflammation. Circulation 110:3349–3354

    Article  PubMed  Google Scholar 

  16. Giusti-Paiva A, Martinez MR, Felix JV, da Rocha MJ, Carnio EC, Elias LL, Antunes-Rodrigues J (2004) Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats. Shock 21:271–275

    Article  PubMed  Google Scholar 

  17. Wagner AH, Schwabe O, Hecker M (2002) Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ. Br J Pharmacol 136:143–149

    PubMed  Google Scholar 

  18. Landry DW,Oliver JA (2001) The pathogenesis of vasodilatory shock. N Engl J Med 345:588–595

    Article  PubMed  Google Scholar 

  19. Ando H, Takamura T, Ota T, Nagai Y, Kobayashi K (2000) Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. J Pharmacol Exp Ther 294:1043–1046

    PubMed  Google Scholar 

  20. Merx MW, Liehn EA, Janssens U, Lutticken R, Schrader J, Hanrath P, Weber C (2004) HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis. Circulation 109:2560–2565

    Article  PubMed  Google Scholar 

  21. Merx MW, Liehn EA, Graf J, van de Sandt A, Schaltenbrand M, Schrader J, Hanrath P, Weber C (2005) Statin treatment after onset of sepsis in a murine model improves survival. Circulation 112:117–124

    Article  PubMed  Google Scholar 

  22. Almog Y, Shefer A, Novack V, Maimon N, Barski L, Eizinger M, Friger M, Zeller L, Danon A (2004) Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation 110:880–885

    Article  PubMed  Google Scholar 

  23. Liappis AP, Kan VL, Rochester CG, Simon GL (2001) The effect of statins on mortality in patients with bacteremia. Clin Infect Dis 33:1352–1357

    Article  PubMed  Google Scholar 

  24. Fernandez R, De Pedro VJ, Artigas A (2005) Statin therapy prior to ICU admission: protection against infection or a severity marker? Intensive Care Med 2005. DOI: 10.1007/s00134-005-2743-9

    Google Scholar 

  25. Kruger P, Fitzsimmons K, Cook D, Jones M, Nimmo G (2005) Statin therapy is associated with fewer deaths in patients with bacteraemia. Intensive Care Med 2005. DOI: 10.1007/s00134-005-2859-y

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Correspondence to Christian Brun-Buisson.

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This editorial refers to the articles http://dx.doi.org/10.1007/s00134-005-2743-9 and http://dx.doi.org./10.1007/s00134-005-2859-y.

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Mekontso-Dessap, A., Brun-Buisson, C. Statins: the next step in adjuvant therapy for sepsis?. Intensive Care Med 32, 11–14 (2006). https://doi.org/10.1007/s00134-005-2860-5

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