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Relationship between the Arg72Pro Polymorphism of p53 and outcome for patients with traumatic brain injury

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Abstract

Objective

To determine the relationship between the Arg72Pro polymorphism of p53 and the outcome after traumatic brain injury (TBI) in humans.

Design and setting

A prospective study was carried out in a ten-bed surgical intensive care unit (SICU) of a university hospital.

Patients

The study included 90 caucasian patients who had experienced a severe TBI within the previous 24 h. The exclusion criterion was a previous deficit in the central nervous system.

Measurements and results

The main recorded outcomes were values on the Glasgow Outcome Scale (GOS) at discharge from the SICU (GOS-0) and 6 months later (GOS-6). A blood sample was taken from each patient and all samples were analyzed by an allele-specific polymerase chain reaction for detection of Arg72Pro polymorphism of p53. These polymorphisms were tested for their association with values of GOS-0 and GOS-6. A two-tailed value of p<0.05 was considered statistically significant. The frequency of the argine/argine (Arg/Arg) genotype was greater among the patients who had a bad outcome at GOS-0 (69 vs 31% in the bad-outcome group; p=0.029). A multiple logistic regression analysis showed that patients with the Arg/Arg variation had a 2.9-fold greater risk of having a bad outcome at discharge from the SICU (95% confidence interval, 1.05–8.31; p=0.039 ). There was no similar relationship with respect to GOS-6.

Conclusion

The Arg/Arg genotype of the Arg72Pro polymorphism in p53 is associated with increased likelihood of a bad outcome at discharge from the SICU.

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Acknowledgements. This study was supported, in part, by a grant from the Research Committee of the General University Hospital of Albacete (Spain). The authors thank Ms. M.G. Picazo for her invaluable technical assistance.

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Authors and Affiliations

  1. Department of Anaesthesia, General University Hospital, C/ Hermanos Falcó 37, 02006, Albacete, Spain

    Pascual Martínez-Lucas, Jerónimo Moreno-Cuesta & Ana Cuartero del Pozo

  2. Experimental Research Unit, General University Hospital, 02006, Albacete, Spain

    Dolores C. García-Olmo & Damián García-Olmo

  3. Department of Genetics, Faculty of Medicine, Castilla-La Mancha University, 02006, Albacete, Spain

    Francisco Sánchez-Sánchez & Julio Escribano-Martínez

  4. Department of Epidemiology, General University Hospital, 02006, Albacete, Spain

    Máxima Lizán-García

Authors
  1. Pascual Martínez-Lucas
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  2. Jerónimo Moreno-Cuesta
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  3. Dolores C. García-Olmo
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  4. Francisco Sánchez-Sánchez
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  5. Julio Escribano-Martínez
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  6. Ana Cuartero del Pozo
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  7. Máxima Lizán-García
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  8. Damián García-Olmo
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Corresponding author

Correspondence to Jerónimo Moreno-Cuesta.

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Martínez-Lucas, P., Moreno-Cuesta, J., García-Olmo, D.C. et al. Relationship between the Arg72Pro Polymorphism of p53 and outcome for patients with traumatic brain injury. Intensive Care Med 31, 1168–1173 (2005). https://doi.org/10.1007/s00134-005-2715-0

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  • DOI: https://doi.org/10.1007/s00134-005-2715-0

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