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Searching for the etiology of systemic inflammatory response syndrome: is SIRS occult endotoxemia?

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References

  1. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP (1995) The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 273:117–123

    Article  PubMed  CAS  Google Scholar 

  2. Stephens R, Fidler K, Wilson P, Barclay G, Mythen M, Dixon G, Turner M, Klein N, Peters M (2005) Endotoxin immunity and the development of the systemic inflammatory response syndrome in critically ill children. Intensive Care Med (http://dx.doi.org/10.1007/s00134-005-0019-z)

  3. Fidler KJ, Wilson P, Davies JC, Turner MW, Peters MJ, Klein NJ (2004) Increased incidence and severity of the systemic inflammatory response syndrome in patients deficient in mannose binding lectin. Intensive Care Med 30:1263–1265

    Article  Google Scholar 

  4. Stephens R, Mythen M (2000) Endotoxin immunization. Intensive Care Med 26:129–135

    Article  Google Scholar 

  5. Camus G, Poortmans J, Nys M, Deby-Dupont G, Duchateau J, Deby C, Lamy M (1997) Mild endotoxemia and the inflammatory response induced by a marathon. Clin Sci (Lond) 92:415–422

    CAS  Google Scholar 

  6. Soong CV, Lewis HG, Halldiay MI, Rowlands BJ (1999) Intramucosal acidosis and the inflammatory response in acute pancreatitis. Am J Gastroenterol 94:2423–2429

    Article  PubMed  CAS  Google Scholar 

  7. Kanwar K, Windsor ACJW, Welsh F, Barclay R, Guillou PJ, Reynolds JV (2000) Lack of correlation between failure of gut barrier function and septic complications after major upper gastrointestinal surgery. Ann Surg 231:88–95

    Article  PubMed  CAS  Google Scholar 

  8. Aydin NB, Gercekoglu H, Aksu B, Ozkul V, Sener T, Kiygil I, Turkoglu T, Cimen S, Babacan F, Demirtas M (2003) Endotoxemia in coronary artery bypass surgery: a comparison of the off-pump technique and conventional cardiopulmonary bypass. J Thorac Cardiovasc Surg 125:843–848

    Article  PubMed  Google Scholar 

  9. Freeman R, Gould FK (1985) Rises in antibody to enteric gram negative bacilli after open heart surgery: a possible mechanism for postoperative hyperpyrexia. Thorax 40:538–541

    Article  PubMed  CAS  Google Scholar 

  10. Freeman R, Gould FK (1985) Prevention of fever and gram negative infection after open heart surgery by antiendotoxin. Thorax 40:846–848

    PubMed  CAS  Google Scholar 

  11. Andersen LW, Landow L, Back L, Jansen E, Baker S (1993) Association between gastric intramucosal pH and splanchnic endotoxin, antibody to endotoxin, and tumor necrosis factor alpha concentrations in patients undergoing cardiopulmonary bypass. Crit Care Med 21:210–217

    Article  PubMed  CAS  Google Scholar 

  12. Bennett-Guerrero E, Asuyo L, Hamilton-Davies C, White WD, Barclay GR, Smith PK, King SA, Muhlbaier LH, Newman MF, Mythen MG (1997) Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery. JAMA 277:646–650

    Article  PubMed  CAS  Google Scholar 

  13. Rothenburger M, Soeparwata R, Deng MC, Berendes E, Schmid C, Tjan TD, Wilhelm MJ, Erren M, Bocker D, Scheld HH (2001) The impact of anti-endotoxin core antibodies on endotoxin and cytokine release and ventilation time after cardiac surgery. J Am Coll Cardiol 38:124–130

    Article  PubMed  CAS  Google Scholar 

  14. Casey WF, Hauser GJ, Hannallah RS, Midgley FM, Khan WN (1992) Circulating endotoxin and tumor necrosis factor during pediatric cardiac surgery. Crit Care Med 20:1090–1096

    Article  PubMed  CAS  Google Scholar 

  15. Khabar KSA, ElBarbary MA, Khouqeer F, Devol E, Al-Gain S, Al-Halees (1997) Circulating endotoxin and cytokines after cardiopulmonary bypass: differential correlation with duration of bypass and systemic inflammatory response /multiple organ dysfunction syndrome. Clin Immunol Immunopathol 85:97–103

    Article  PubMed  CAS  Google Scholar 

  16. Lequeier LL, Nikaidoh H, Leonard SR, Bokovoy JL, White ML, Scannon PJ, Giroir BP (2000) Preoperative and postoperative endotoxemia in children with congenital heart disease. Chest 117:1706–1712

    Article  PubMed  Google Scholar 

  17. Mou SS, Haudek SB, Lequier L, Pena O, Leonard S, Hisashi N, Giroir B, Stromberg D (2002) Myocardial inflammatory activation in children with congenital heart disease. Crit Care Med 39:827–832

    Article  Google Scholar 

  18. Allen ML, Peters MJ, Goldman A, Elliott M, James I, Callard R, Klein NJ (2002) Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care. Critical Care Med 30:1140–1145

    Article  Google Scholar 

  19. Bennett-Guerrero E, Barclay GR, Youssef ME, Hossain S, Vela-Cantos F, Andres LA, Poxton IR (2000) Exposure to Bacteroides fragilis endotoxin during cardiac surgery. Anesth Analg 90:819–823

    Article  PubMed  CAS  Google Scholar 

  20. Bouter H, Schippers EF, Luelmo SA, Versteegh MI, Ros P, Guiot HF, Frolich M, van Dissel JT (2002) No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation during cardiopulmonary bypass: a randomized, placebo-controlled study. Crit Care Med 30:38–43

    Article  PubMed  CAS  Google Scholar 

  21. Friedrich I, Silber RE, Baumann B, Fisher C, Holzheimer RG (2002) IgM-enriched immunoglobulin preparation for immunoprophylaxis in cardiac surgery. Eur J Med Res 7:544–549

    PubMed  Google Scholar 

  22. Xia ZY, Zhan LY, He YH, Liu XY (2003) The effect of Shen-Fu on gastrointestinal tract injury and its potential mechanism during cardiopulmonary bypass in patients undergoing cardiac surgery. Chin J Traumatol 6:245–248

    PubMed  Google Scholar 

  23. Xia ZY, Liu XY, Zhan LY, He YH, Luo T, Xia Z (2005) Ginsenosides compound (shen-fu) attenuates gastrointestinal injury and inhibits inflammatory response after cardiopulmonary bypass in patients with congenital heart disease. J Thorac Cardiovasc Surg 130:258–264

    Article  PubMed  CAS  Google Scholar 

  24. Yndgaard S, Andersen LW, Andersen C, Petterson G, Baek L (2000) The effect of modified ultrafiltration on the amount of circulating endotoxins in children undergoing cardiopulmonary bypass. J Cardiothorac Vasc Anesth 14:399–401

    Article  PubMed  CAS  Google Scholar 

  25. Barclay GR (1999) Endotoxin core antibodies: time for a reappraisal? Intensive Care Med 25:427–429

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Critical Care Medicine, Children's Hospital of Pittsburgh, Pittsburgh, Pa., USA

    Joseph A. Carcillo

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  1. Joseph A. Carcillo
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Correspondence to Joseph A. Carcillo.

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This editorial refers to the contribution available at: http://dx.doi.org/10.1007/s00134-005-0019-z

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Carcillo, J.A. Searching for the etiology of systemic inflammatory response syndrome: is SIRS occult endotoxemia?. Intensive Care Med 32, 181–184 (2006). https://doi.org/10.1007/s00134-005-0067-4

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