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Cardiac troponin I release and cytokine response during experimental human endotoxaemia

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Abstract

Objective

To study the relationship between cytokine levels and cardiac troponin I (cTnI).

Design

Prospective experimental study.

Setting

Intensive care unit of a university hospital.

Participants

Six healthy male volunteers.

Interventions

Endotoxin, 4 ng/kg, was given as a 1-min intravenous infusion.

Measurements and results

Circulating cardiac troponin I levels and proinflammatory cytokines tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) were analysed at various time points during a 24-h period. TNF-α appeared in the circulation 30 min after injection (T=0.5 h), reaching peak levels (5,665±1,910 pg/ml) 2 h after infusion. At T=24 h TNF-α was still elevated in the circulation compared to T=0. None of the six volunteers had a cTnI value higher than 0.1 μg/l at T=0, 6 h or 24 h.

Conclusion

The presence of significant amounts of TNF-α, IL-6 and IL-8 in the systemic circulation does not lead to increased levels of cTnI in experimental human endotoxaemia.

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Authors and Affiliations

  1. Intensive and Respiratory Care Unit, Department of Internal Medicine , University Hospital Groningen, PO Box 30.001, 9700 RB , Groningen, The Netherlands

    Esther A. P. van Bockel, Jaap E. Tulleken, Anneke C. Muller Kobold, Jack J. M. Ligtenberg, Tjip S. van der Werf & Rob Spanjersberg

Authors
  1. Esther A. P. van Bockel
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  2. Jaap E. Tulleken
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  3. Anneke C. Muller Kobold
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  4. Jack J. M. Ligtenberg
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  5. Tjip S. van der Werf
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  6. Rob Spanjersberg
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  7. Jan G. Zijlstra
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Corresponding author

Correspondence to Jaap E. Tulleken.

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van Bockel, E.A.P., Tulleken, J.E., Muller Kobold, A.C. et al. Cardiac troponin I release and cytokine response during experimental human endotoxaemia. Intensive Care Med 29, 1598–1600 (2003). https://doi.org/10.1007/s00134-003-1893-x

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  • DOI: https://doi.org/10.1007/s00134-003-1893-x

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