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Knochenmarködem im Kniegelenk

Differenzialdiagnostik und therapeutische Möglichkeiten

Bone marrow edema in the knee

Differential diagnosis and therapeutic possibilities

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Zusammenfassung

Ein Knochenmarködem (KMÖ) ist ein häufiger Befund bei der Abklärung von schmerzhaften Kniegelenken mit der Magnetresonanztomographie (MRT). Sein typisches Signalverhalten ist unspezifisch, und es tritt bei zahlreichen Krankheitsbildern auf. Die Differenzialdiagnose der unterschiedlichen KMÖ des Kniegelenks ist wichtig, da sich daraus verschiedene therapeutische Konsequenzen ergeben. In dieser Übersichtsarbeit werden die schmerzhaften KMÖ ätiologisch in 3 Gruppen unterteilt: Gruppe 1: ischämische KMÖ: Osteonekrose, Osteochondrosis dissecans, Knochenmarködemsyndrom und „complex regional pain syndrome“, Gruppe 2: mechanische KMÖ: Knochenmarkkontusion und Mikrofraktur sowie Stress-KMÖ und Stressfraktur, Gruppe 3: reaktive KMÖ: Gonarthritis, Gonarthrose, postoperativ und Tumoren. Die typische MRT-Morphologie und die Differenzialdiagnosen dieser unterschiedlichen KMÖ-Erscheinungsbilder werden besprochen und die sich daraus ergebenden therapeutischen Konsequenzen kurz dargestellt.

Abstract

The Bone marrow edema (BME) is a common finding when evaluating patients with knee pain by magnetic resonance imaging (MRI). The typical signal patterns of BME are unspecific and can be found with different diseases of the knee. Since different therapeutic approaches are mandatory, differential diagnosis of the several forms of BME is important. In this review, painful BME will be separated into three different etiological groups. Group 1 ischemic BME: osteonecrosis, osteochondritis dissecans, bone marrow edema syndrome and complex regional pain syndrome. Group 2 mechanical BME: bone bruises, microfracture, stress-BME und stress fracture. Group 3 reactive BME: inflammatory gonarthritis, degenerative gonarthrosis, postoperative and tumours. The typical MRI morphologies and differential diagnosis of these BME manifestations will be described. The different therapeutic consequences will also be briefly mentioned.

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Literatur

  1. Aigner N, Steinböck G, Schneider W et al. (2001) Treatment of bone marrow edema of the talus with the prostacyclin analogue iloprost: an MRI-controlled investigation of a new method. J Bone Joint Surg Br 83-B: 855–858

  2. Aigner N, Breitenseher M, Hofmann S et al. (2003) Treatment of bone marrow edema of the knee with the prostacyclin analogue iloprost. ARCO Meeting, Seoul, Abstract 104

  3. Aigner N, Petje G, Schneider W et al. (2005) Bone marrow edema syndrome of the femoral head: treatment with the prostacyclin analogue iloprost vs. core decompression: an MRI-controlled study. Wien Klin Wochenschr 117: 130–135

    Article  PubMed  Google Scholar 

  4. Athanasian EA, Wickiewicz TL, Warren RF (1995) Osteonecrosis of the femoral condyle after arthroscopic reconstruction of a cruciate ligament. Report of two cases. J Bone Joint Surg Am 77: 1418–1422

    PubMed  Google Scholar 

  5. Beltran J, Shankman S (1994) Magnetic resonance imaging of bone marrow disorders of the knee. Magn Reson Imaging Clin N Am 2: 463–473

    PubMed  Google Scholar 

  6. Breitenseher MJ, Gaebler C (1997) Trauma of the wrist. Eur J Radiol 25: 129–139

    Article  PubMed  Google Scholar 

  7. Breitenseher MJ, Kramer J, Mayerhoefer ME et al. (2006) Differentialdiagnosen des Knochenmarködems am Knie. Radiologe 46: 46–54

    Article  PubMed  Google Scholar 

  8. Daffner RH, Pavlov H (1992) Stress fractures: current concepts. Am J Roentgenol 159: 245–252

    Google Scholar 

  9. Disch AC, Matziolis G, Perka C (2005) The management of necrosis-associated and idiopathic bone-marrow oedema of the proximal femur by intravenous iloprost. J Bone Joint Surg Br 87: 560–564

    Article  PubMed  Google Scholar 

  10. Ecker ML, Lotke PA (1995) Osteonecrosis of the medial part of the tibial plateau. J Bone Joint Surg Am 77: 596–601

    PubMed  Google Scholar 

  11. Felson DT, Chaisson CE, Hill CL et al. (2001) The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 134: 541–549

    PubMed  Google Scholar 

  12. Hayes CW, Brigido MK, Jamadar DA, Propeck T (2000) Mechanism-based pattern approach to classification of complex injuries of the knee depicted at MR imaging. Radiographics 20: 121–S134

    PubMed  Google Scholar 

  13. Hofmann S (2005) The painful bone marrow edema syndrome of the hip joint. Wien Klin Wochenschr 117: 111–120

    Article  PubMed  Google Scholar 

  14. Hofmann S, Engel A, Neuhold A et al. (1993) Bone-marrow oedema syndrome and transient osteoporosis of the hip. An MRI-controlled study of treatment by core decompression. J Bone Joint Surg Br 75: 210–216

    PubMed  Google Scholar 

  15. Hofmann S, Schneider W, Breitenseher M et al. (2000) Die „transiente Osteoporose“ als reversible Sonderform der Hüftkopfnekrose. Orthopäde 29: 411–419

    Google Scholar 

  16. Hofmann S, Kramer J, Vakil-Adli A et al. (2004) Painful bone marrow edema of the knee: differential diagnosis and therapeutic concepts. Orthop Clin North Am 35: 321–333

    Article  PubMed  Google Scholar 

  17. Hogan C, Hurwitz S (2002) Treatment of complex regional pain syndrome of the lower extremity. J Am Acad Orthop Surg 10: 281–289

    PubMed  Google Scholar 

  18. Ishida T, Goto T, Motoi N, Mukai K (2002) Intracortical chondroblastoma mimicking intra-articular osteoid osteoma. Skeletal Radiol 31: 603–607

    Article  PubMed  Google Scholar 

  19. Kobayashi Y, Kimura M, Higuchi H et al. (2002) Juxta-articular bone marrow signal changes on magnetic resonance imaging following arthroscopic meniscectomy. Arthroscopy 18: 238–245

    PubMed  Google Scholar 

  20. Krampla W, Mayrhofer R, Malcher J et al. (2001) MR imaging of the knee in marathon runners before and after competition. Skeletal Radiol 30: 72–76

    Article  PubMed  Google Scholar 

  21. Lakhanpal S, Ginsburg WW, Luthra HS, Hunder GG (1987) Transient regional osteoporosis. A study of 56 cases and review of the literature. Ann Intern Med 106: 444–450

    PubMed  Google Scholar 

  22. Lecouvet FE, Van de Berg BC, Maldague BE et al. (1998) Early irreversible osteonecrosis versus transient lesions of the femoral condyles: prognostic value of subchondral bone and marrow changes on MR imaging. AJR Am J Roentgenol 170: 71–77

    PubMed  Google Scholar 

  23. Marti CB, Rodriguez M, Zanetti M, Romero J (2000) Spontaneous osteonecrosis of the medial compartment of the knee: a MRI follow-up after conservative and operative treatment, preliminary results. Knee Surg Sports Traumatol Arthrosc 8: 83–88

    Article  PubMed  Google Scholar 

  24. Meizer R, Radda C, Stolz G et al. (2005) MRI-controlled analysis of 104 patients with painful bone marrow edema in different joint localizations treated with the prostacyclin analogue iloprost. Wien Klin Wochenschr 117: 278–286

    Article  PubMed  Google Scholar 

  25. Muscolo DL, Costa Paz M, Makino A, Ayerza MA (1996) Osteonecrosis of the knee following arthroscopic meniscectomy in patients over 50-years old. Arthroscopy 12: 273–279

    PubMed  Google Scholar 

  26. Nakamura N, Horibe S, Nakamura S, Mitsuoka T (2002) Subchondral microfracture of the knee without osteonecrosis after arthroscopic medial meniscectomy. Arthroscopy 18: 538–541

    PubMed  Google Scholar 

  27. Pape D, Seil R, Fritsch E et al. (2002) Prevalence of spontaneous osteonecrosis of the medial femoral condyle in elderly patients. Knee Surg Sports Traumatol Arthrosc 10: 233–240

    PubMed  Google Scholar 

  28. Pape D, Seil R, Kohn D, Schneider G (2004) Imaging of early stages of osteonecrosis of the knee. Orthop Clin North Am 35: 293–303

    Article  PubMed  Google Scholar 

  29. Plenk H Jr, Hofmann S, Eschberger J et al. (1997) Histomorphology and bone morphometry of the bone marrow edema syndrome of the hip. Clin Orthop 334: 73–84

    Article  PubMed  Google Scholar 

  30. Roemer FW, Bohndorf K (2002) Long-term osseous sequelae after acute trauma of the knee joint evaluated by MRI. Skeletal Radiol 31: 615–623

    Article  PubMed  Google Scholar 

  31. Schweitzer ME, White LM (1996) Does altered biomechanics cause marrow edema? Radiology 198: 851–853

    PubMed  Google Scholar 

  32. Vahlensieck M, Reiser M (1997) MRT des Bewegungsapparates. Thieme, Stuttgart New York, 1: 143–167

  33. Wall E, von Stein D (2003) Juvenile osteochondritis dissecans. Orthop Clin North Am 34: 341–353

    Article  PubMed  Google Scholar 

  34. Yamamoto T, Bullough PG (2000) Spontaneous osteonecrosis of the knee: the result of subchondral insufficiency fracture. J Bone Joint Surg Am 82: 858–866

    Article  PubMed  Google Scholar 

  35. Zanetti M, Bruder E, Romero J, Hodler J (2000) Bone marrow edema pattern in osteoarthritic knees: correlation between MR imaging and histologic findings. Radiology 215: 835–840

    PubMed  Google Scholar 

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Interessenkonflikt

Der korrespondierende Autor weist auf eine Verbindung mit folgender Firma/Firmen hin: Der korrespondierende Autor ist als Berater für klinische Studien für die Firma Schering tätig.

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Correspondence to S. Hofmann.

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Hofmann, S., Kramer, J., Breitenseher, M. et al. Knochenmarködem im Kniegelenk. Orthopäde 35, 463–477 (2006). https://doi.org/10.1007/s00132-006-0952-8

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  • DOI: https://doi.org/10.1007/s00132-006-0952-8

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