Literatur
WHO (2012) Born too soon: the global action report on preterm birth. World Health Organization, Geneva (March of Dimes. PMNCH, S.t.C.)
Vogel JP et al (2014) Use of antenatal corticosteroids and tocolytic drugs in preterm births in 29 countries: an analysis of the WHO Multicountry Survey on Maternal and Newborn Health. Lancet 384(9957):1869–1877
Schoen CN et al (2015) Why the United States preterm birth rate is declining. Am J Obstet Gynecol 213(2):175–180
Zahn V (1984) Uterine contractions during pregnancy. J Perinat Med 12(3):107–113
Tsoi E et al (2003) Ultrasound assessment of cervical length in threatened preterm labor. Ultrasound Obstet Gynecol 21(6):552–555
Schleußner E (2013) Drohende Frühgeburt. Dtsch Arztebl Int 110(13):227–236
Hosli I et al (2014) Tocolysis for preterm labor: expert opinion. Arch Gynecol Obstet 289(4):903–909
ACOG (2012) Management of preterm labor. Obstet Gynecol 119(6):1308–1317
Hiersch L et al (2014) The role of cervical length in women with threatened preterm labor: is it a valid predictor at any gestational age? Am J Obstet Gynecol 211(5):1–9
Iams JD et al (2011) The rate of cervical change and the phenotype of spontaneous preterm birth. Am J Obstet Gynecol 205(2):130.e1–6
Ting HS et al (2007) Comparison of bedside test kits for prediction of preterm delivery: phosphorylated insulin-like growth factor binding protein-1 (pIGFBP-1) test and fetal fibronectin test. Ann Acad Med Singapore 36(6):399–402
Nikolova T et al (2015) Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor. J Perinat Med 43(4):395–402
van Baaren GJ et al (2014) Predictive value of cervical length measurement and fibronectin testing in threatened preterm labor. Obstet Gynecol 123(6):1185–1192
Vis JY et al (2015) Randomized comparison of nifedipine and placebo in fibronectin-negative women with symptoms of preterm labor and a short cervix (APOSTEL-I Trial). Am J Perinatol 32(5):451–460
Romero R, Dey SK, Fisher SJ (2014) Preterm labor: one syndrome, many causes. Science 345(6198):760–765
Haram K, Mortensen JH, Morrison JC (2015) Tocolysis for acute preterm labor: does anything work. J Matern Fetal Neonatal Med 28(4):371–378
Haas DM et al (2012) Tocolytic therapy for preterm delivery: systematic review and network meta-analysis. BMJ 345:e6226
RCOG (2011) Tocolysis for Women in Preterm Labour. Green-top Guideline, 2011. 1b. RCOG, London
Eke AC et al (2016) A systematic review and meta-analysis of progestogen use for maintenance tocolysis after preterm labor in women with intact membranes. Int J Gynaecol Obstet 132(1):11–16
van Vliet E et al (2015) Maintenance tocolysis with nifedipine in threatened preterm labour: 2‑year follow up of the offspring in the APOSTEL II trial. BJOG. doi:10.1111/1471-0528.13586
RCOG (2010) Antenatal Corticosteroids to Reduce Neonatal Morbidity and Mortality. Green-top Guideline No. 7, 2010. RCOG, London
Ecker JL et al (2015) 3: Periviable birth. Am J Obstet Gynecol 213(5):604–614
Gaspar R, Hajagos-Toth J (2013) Calcium channel blockers as tocolytics: principles of their actions, adverse effects and therapeutic combinations. Pharmaceuticals (Basel) 6(6):689–699
Wray S et al (2003) Calcium signaling and uterine contractility. J Soc Gynecol Investig 10(5):252–264
Lima MM et al (2009) Doppler velocimetry of the uterine, umbilical and fetal middle cerebral arteries in pregnant women undergoing tocolysis with oral nifedipine. Ultrasound Obstet Gynecol 34(3):311–315
Grzesiak M, Ahmed RB, Wilczynski J (2013) 48-hours administration of nifedipine in spontaneous preterm labor – Doppler blood flow assessment of placental and fetal circulation. Neuro Endocrinol Lett 34(7):687–692
Guclu S et al (2006) Nifedipine therapy for preterm labor: effects on placental, fetal cerebral and atrioventricular Doppler parameters in the first 48 hours. Ultrasound Obstet Gynecol 27(4):403–408
Flenady V et al (2014) Calcium channel blockers for inhibiting preterm labour and birth. Cochrane Database Syst Rev 6:Cd002255
van Vliet EO et al (2014) Nifedipine versus atosiban in the treatment of threatened preterm labour (assessment of Perinatal outcome after specific Tocolysis in early labour: aPOSTEL III-trial). BMC Pregnancy Childbirth 14:93
Naik Gaunekar N et al (2013) Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour. Cochrane Database Syst Rev 10:Cd004071
Parry E et al (2014) The NIFTY study: a multicentre randomised double-blind placebo-controlled trial of nifedipine maintenance tocolysis in fetal fibronectin-positive women in threatened preterm labour. Aust N Z J Obstet Gynaecol 54(3):231–236
World Health Organization (2015) WHO guidelines approved by the guidelines review committee. In: WHO recommendations on interventions to improve preterm birth outcomes. World Health Organization, Geneva
Eliasson R, Posse N (1960) The effect of prostaglandin on the nonpregnant human uterus in vivo. Acta Obstet Gynecol Scand 39(1):112–126
Zuckerman H, Reiss U, Rubinstein I (1974) Inhibition of human premature labor by indomethacin. Obstet Gynecol 44(6):787–792
Goldenberg RL et al (2008) Epidemiology and causes of preterm birth. Lancet 371(9606):75–84
Rinaldi SF et al (2011) Anti-inflammatory mediators as physiological and pharmacological regulators of parturition. Expert Rev Clin Immunol 7(5):675–696
Romero R et al (2006) The preterm parturition syndrome. BJOG 113(3):17–42
Abou-Ghannam G, Usta IM, Nassar AH (2012) Indomethacin in pregnancy: applications and safety. Am J Perinatol 29(3):175–186
Hammers AL, Sanchez-Ramos L, Kaunitz AM (2015) Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. Am J Obstet Gynecol 212(4):1–13
Loe SM, Sanchez-Ramos L, Kaunitz AM (2005) Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. Obstet Gynecol 106(1):173–179
Reinebrant HE et al (2015) Cyclo-oxygenase (COX) inhibitors for treating preterm labour. Cochrane Database Syst Rev 6:Cd001992
Lopez Bernal A (2007) The regulation of uterine relaxation. Semin Cell Dev Biol 18(3):340–347
Neilson JP, West HM, Dowswell T (2014) Betamimetics for inhibiting preterm labour. Cochrane Database Syst Rev 2:Cd004352
Flenady V et al (2014) Oxytocin receptor antagonists for inhibiting preterm labour. Cochrane Database Syst Rev 6:Cd004452
Wex J et al (2011) Atosiban versus betamimetics in the treatment of preterm labour in Italy: clinical and economic importance of side-effects. Eur J Obstet Gynecol Reprod Biol 157(2):128–135
Wex J, Connolly M, Rath W (2009) Atosiban versus betamimetics in the treatment of preterm labour in Germany: an economic evaluation. BMC Pregnancy Childbirth 9:23
Siassakos D, O’Brien K, Draycott T (2009) Healthcare evaluation of the use of atosiban and fibronectin for the management of pre-term labour. J Obstet Gynaecol (Lahore) 29(6):507–511
Crowther CA et al (2014) Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 8:Cd001060
Haas DM et al (2015) Ethanol for preventing preterm birth in threatened preterm labor. Cochrane Database Syst Rev 11:Cd011445
Flenady V et al (2013) Prophylactic antibiotics for inhibiting preterm labour with intact membranes. Cochrane Database Syst Rev 12:Cd000246
Stan CM et al (2013) Hydration for treatment of preterm labour. Cochrane Database Syst Rev 11:Cd003096
Sosa CG et al (2015) Bed rest in singleton pregnancies for preventing preterm birth. Cochrane Database Syst Rev 3:Cd003581
Plangger N et al (2006) Intravenous tocolysis with Bryophyllum pinnatum is better tolerated than beta-agonist application. Eur J Obstet Gynecol Reprod Biol 124(2):168–172
Khianman B et al (2012) Relaxation therapy for preventing and treating preterm labour. Cochrane Database Syst Rev 8:Cd007426
Vogel JP et al (2014) Combination of tocolytic agents for inhibiting preterm labour. Cochrane Database Syst Rev 7:Cd006169
Martinez de Tejada B et al (2015) Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial. BJOG 122(1):80–91
Suhag A, Saccone G, Berghella V (2015) Vaginal progesterone for maintenance tocolysis: a systematic review and metaanalysis of randomized trials. Am J Obstet Gynecol 213(4):479–487
Eke AC et al (2016) A systematic review and meta-analysis of progestogen use for maintenance tocolysis after preterm labor in women with intact membranes. Int J Gynaecol Obstet 132(1):11–16
Pařízek A, Koucký M, Dušková M (2014) Progesterone, inflammation and preterm labor. J Steroid Biochem Mol Biol 139:159–165
Baumbach J et al (2012) Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies. Am J Obstet Gynecol 206(3):1–5
Pearl J et al (2011) Guidelines for diagnosis, treatment, and use of laparoscopy for surgical problems during pregnancy. Surg Endosc 25(11):3479–3492
Smith J, DeFranco EA (2015) Tocolytics used as adjunctive therapy at the time of cerclage placement: a systematic review. J Perinatol 35(8):561–565
Cluver C et al (2015) Interventions for helping to turn term breech babies to head first presentation when using external cephalic version. Cochrane Database Syst Rev 2:Cd000184
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F. Voigt, A. Farrokh, C. Franz, N. Maass, E. Stickeler und T.W. Goecke geben an, dass kein Interessenkonflikt besteht.
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Voigt, F., Farrokh, A., Franz, C. et al. Tokolyse – Update 2016. Gynäkologe 49, 201–211 (2016). https://doi.org/10.1007/s00129-016-3844-y
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DOI: https://doi.org/10.1007/s00129-016-3844-y