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Lethality Toxicities Induced by Metal Exposure During Development in Nematode Caenorhabditis Elegans

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Abstract

Lethality changes were investigated during development in 4 h metal exposed Caenorhabditis elegans. Exposure to examined metals caused severe lethality toxicities in L1- and L2-larvae, in L3-larvae exposed to examined metals at concentrations of 50 and 100 μM and to Pb, Hg, and Cr at the concentration of 2.5 μM, in L4-larvae exposed to examined metals at concentrations of 50 and 100 μM, and in adults exposed to Pb, Hg, and Cr at the concentration of 100 μM. Moreover, the lethality toxicities induced by Pb and Hg in L1 larvae for 4 h could be largely comparable to those in young adults for 24 h.

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Acknowledgments

Strain used in this study was provided by the Caenorhabdits Genetics Center (funded by the NIH National Center for Research Resource, USA). This work was supported by grants from the National Natural Science Foundation of China (No. 30771113, 30870810) and the Program for New Century Excellent Talents in University.

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Authors and Affiliations

  1. Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Department of Genetics and Developmental Biology, Southeast University, Nanjing, 210009, China

    X. Xing, Q. Rui & D. Wang

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  1. X. Xing
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  2. Q. Rui
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  3. D. Wang
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Correspondence to D. Wang.

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Xing, X., Rui, Q. & Wang, D. Lethality Toxicities Induced by Metal Exposure During Development in Nematode Caenorhabditis Elegans . Bull Environ Contam Toxicol 83, 530–536 (2009). https://doi.org/10.1007/s00128-009-9816-3

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  • DOI: https://doi.org/10.1007/s00128-009-9816-3

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