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The ‘Early Developmental Stages of Psychopathology (EDSP) study’: a 20-year review of methods and findings

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Abstract

Purpose

The “Early Developmental Stages of Psychopathology (EDSP)” study is a prospective-longitudinal study program in a community sample (Munich, Germany) of adolescents and young adults. The program was launched in 1994 to study the prevalence and incidence of psychopathological syndromes and mental disorders, to describe the natural course and to identify vulnerability and risk factors for onset and progression as well as psychosocial consequences. This paper reviews methods and core outcomes of this study program.

Methods

The EDSP is based on an age-stratified random community sample of originally N = 3021 subjects aged 14–24 years at baseline, followed up over 10 years with up to 3 follow-up waves. The program includes a family genetic supplement and nested cohorts with lab assessments including blood samples for genetic analyses. Psychopathology was assessed with the DSM-IV/M-CIDI; embedded dimensional scales and instruments assessed vulnerability and risk factors.

Results

Beyond the provision of age-specific prevalence and incidence rates for a wide range of mental disorders, analyses of their patterns of onset, course and interrelationships, the program identified common and diagnosis-specific distal and proximal vulnerability and risk factors including critical interactions.

Conclusions

The EDSP study advanced our knowledge on the developmental pathways and trajectories, symptom progression and unfolding of disorder comorbidity, highlighting the dynamic nature of many disorders and their determinants. The results have been instrumental for defining more appropriate diagnostic thresholds, led to the derivation of symptom progression models and were helpful to identify promising targets for prevention and intervention.

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Notes

  1. Previous publications include assessments up to T2. Completed information on assessments up to T3 is available from the corresponding author upon request.

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Acknowledgments

This work is part of the Early Developmental Stages of Psychopathology (EDSP) Study and is funded by the German Federal Ministry of Education and Research (BMBF) project no. 01EB9405/6, 01 EB 9901/6, EB01016200, 01EB0140 and 01EB0440. Part of the field work and analyses were also additionally supported by grants of the Deutsche Forschungsgemeinschaft (DFG) LA1148/1-1, WI2246/1-1, WI 709/7-1 and WI 709/8-1. Principal investigators are Dr. Hans-Ulrich Wittchen and Dr. Roselind Lieb who take responsibility for the integrity of the study data. Core staff members of the EDSP group are: Dr. Kirsten von Sydow, Dr. Gabriele Lachner, Dr. Axel Perkonigg, Dr. Peter Schuster, Dr. Michael Höfler, Dipl.-Psych. Holger Sonntag, Dr. Tanja Brückl, Dipl.-Psych. Elzbieta Garczynski, Dr. Barbara Isensee, Dr. Agnes Nocon, Dr. Chris Nelson, Dipl.-Inf. Hildegard Pfister, Dr. Victoria Reed, Dipl.-Soz. Barbara Spiegel, Dr. Andrea Schreier, Dr. Ursula Wunderlich, Dr. Petra Zimmermann, Dr. Katja Beesdo-Baum, Dr. Antje Bittner, Dr. Silke Behrendt and Dr. Susanne Knappe. Scientific advisors are Dr. Jules Angst (Zurich), Dr. Jürgen Margraf (Basel), Dr. Günther Esser (Potsdam), Dr. Kathleen Merikangas (NIMH, Bethesda), Dr. Ron Kessler (Harvard, Boston) and Dr. Jim van Os (Maastricht).

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standards

The study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments and has been approved by the ethics committee of the Medical Faculty of the Technische Universität Dresden.

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Authors and Affiliations

  1. Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, 01187, Dresden, Germany

    Katja Beesdo-Baum, Susanne Knappe, Eva Asselmann, Michael Höfler, Silke Behrendt & Hans-Ulrich Wittchen

  2. Behavioral Epidemiology, Technische Universität Dresden, Dresden, Germany

    Katja Beesdo-Baum & Eva Asselmann

  3. Max Planck Institute of Psychiatry, Munich, Germany

    Petra Zimmermann, Tanja Brückl, Roselind Lieb & Hans-Ulrich Wittchen

  4. Division of Clinical Psychology and Epidemiology, Department of Psychology, University of Basel, Basel, Switzerland

    Roselind Lieb

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  1. Katja Beesdo-Baum
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Correspondence to Katja Beesdo-Baum.

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Beesdo-Baum, K., Knappe, S., Asselmann, E. et al. The ‘Early Developmental Stages of Psychopathology (EDSP) study’: a 20-year review of methods and findings. Soc Psychiatry Psychiatr Epidemiol 50, 851–866 (2015). https://doi.org/10.1007/s00127-015-1062-x

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