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Mortality of people suffering from mental illness: a study of a cohort of patients hospitalised in psychiatry in the North of France

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Abstract

Background

The mortality of people suffering from psychiatric illnesses is far higher than that of the general population, all categories of diagnosis combined; mortality statistics can be used as an index of quality of care. The aim of this study was to assess the all-cause mortality in psychiatric patients covering all diagnostic groups.

Methods

The living or deceased status of 4,417 patients of majority age hospitalised in a public mental health establishment between 2004 and 2007 were requested from French National Institute for Statistics and Economic Studies on 1st January 2011. The cause of death of those people who had died was obtained from French National Institute for Health and Medical Research and comparative standardized mortality ratios (SMR) were established from the population in a region of northern France of the same age in 2006.

Results

The study population was made up of 54 % men and 46 % women, median age 41 and 45 years old, respectively. Four hundred and seventy-three people died during the period studied. The SMR were 421 for men (95 % CI 378–470) and 330 for women (95 % CI 281–388). The highest SMRs were found in patients aged 35–54, with a 20-time higher mortality risk than the general population of the same age.

Conclusion

Our study confirms the considerably higher mortality in psychiatric patients than in general population, particularly in mean age and mostly due to an unnatural cause.

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References

  1. Harris EC, Barraclough B (1998) Excess mortality of mental disorder. Br J Psychiatry 173:11–53

    Article  CAS  PubMed  Google Scholar 

  2. Hewer W, Rossler W, Fatkenheuer B, Loffler W (1995) Mortality among patients in psychiatric hospitals in Germany. Acta Psychiatr Scand 91(3):174–179

    Article  CAS  PubMed  Google Scholar 

  3. Martin RL, Cloninger CR, Guze SB, Clayton PJ (1985) Mortality in a follow-up of 500 psychiatric outpatients. I. Total mortality. Arch Gen Psychiatry 42(1):47–54

    Article  CAS  PubMed  Google Scholar 

  4. Ringback Weitoft G, Gullberg A, Rosen M (1998) Avoidable mortality among psychiatric patients. Soc Psychiatry Psychiatr Epidemiol 33(9):430–437

    Article  CAS  PubMed  Google Scholar 

  5. Sohlman B, Lehtinen V (1999) Mortality among discharged psychiatric patients in Finland. Acta Psychiatr Scand 99(2):102–109

    Article  CAS  PubMed  Google Scholar 

  6. Wahlbeck K, Westman J, Nordentoft M, Gissler M, Laursen TM (2011) Outcomes of Nordic mental health systems: life expectancy of patients with mental disorders. Br J Psychiatry 199(6):453–458

    Article  PubMed  Google Scholar 

  7. Simpson JC, Tsuang MT (1996) Mortality among patients with schizophrenia. Schizophr Bull 22(3):485–499

    Article  CAS  PubMed  Google Scholar 

  8. Joukamaa M, Heliovaara M, Knekt P, Aromaa A, Raitasalo R, Lehtinen V (2001) Mental disorders and cause-specific mortality. Br J Psychiatry 179:498–502

    Article  CAS  PubMed  Google Scholar 

  9. Amaddeo F, Bisoffi G, Bonizzato P, Micciolo R, Tansella M (1995) Mortality among patients with psychiatric illness. A ten-year case register study in an area with a community-based system of care. Br J Psychiatry 166(6):783–788

    Article  CAS  PubMed  Google Scholar 

  10. Meloni D, Miccinesi G, Bencini A, Conte M, Crocetti E, Zappa M, Ferrara M (2006) Mortality among discharged psychiatric patients in Florence, Italy. Psychiatr Serv 57(10):1474–1481

    Article  PubMed  Google Scholar 

  11. Politi P, Piccinelli M, Klersy C, Madini S, Segagni LG, Fratti C, Barale F (2002) Mortality in psychiatric patients 5 to 21 years after hospital admission in Italy. Psychol Med 32(2):227–237

    Article  CAS  PubMed  Google Scholar 

  12. Hansen V, Jacobsen BK, Arnesen E (2001) Cause-specific mortality in psychiatric patients after deinstitutionalisation. Br J Psychiatry 179:438–443

    Article  CAS  PubMed  Google Scholar 

  13. Rasanen S, Hakko H, Viilo K, Meyer-Rochow VB, Moring J (2003) Excess mortality among long-stay psychiatric patients in Northern Finland. Soc Psychiatry Psychiatr Epidemiol 38(6):297–304

    PubMed  Google Scholar 

  14. Hoyer EH, Mortensen PB, Olesen AV (2000) Mortality and causes of death in a total national sample of patients with affective disorders admitted for the first time between 1973 and 1993. Br J Psychiatry 176:76–82

    Article  CAS  PubMed  Google Scholar 

  15. Lawrence D, Holman CD, Jablensky AV, Threlfall TJ, Fuller SA (2000) Excess cancer mortality in Western Australian psychiatric patients due to higher case fatality rates. Acta Psychiatr Scand 101(5):382–388

    Article  CAS  PubMed  Google Scholar 

  16. Yim PH, Yip PS, Li RH, Dunn EL, Yeung WS, Miao YK (2004) Suicide after discharge from psychiatric inpatient care: a case–control study in Hong Kong. Aust N Z J Psychiatry 38(1–2):65–72

    Article  PubMed  Google Scholar 

  17. Schneider B, Muller MJ, Philipp M (2001) Mortality in affective disorders. J Affect Disord 65(3):263–274

    Article  CAS  PubMed  Google Scholar 

  18. Mortensen PB, Juel K (1990) Mortality and causes of death in schizophrenic patients in Denmark. Acta Psychiatr Scand 81(4):372–377

    Article  CAS  PubMed  Google Scholar 

  19. Valenti M, Necozione S, Busellu G, Borrelli G, Lepore AR, Madonna R, Altobelli E, Mattei A, Torchio P, Corrao G, Di Orio F (1997) Mortality in psychiatric hospital patients: a cohort analysis of prognostic factors. Int J Epidemiol 26(6):1227–1235

    Article  CAS  PubMed  Google Scholar 

  20. D’Avanzo B, La Vecchia C, Negri E (2003) Mortality in long-stay patients from psychiatric hospitals in Italy—results from the Qualyop Project. Soc Psychiatry Psychiatr Epidemiol 38(7):385–389

    PubMed  Google Scholar 

  21. Druss BG, Bradford DW, Rosenheck RA, Radford MJ, Krumholz HM (2000) Mental disorders and use of cardiovascular procedures after myocardial infarction. JAMA 283(4):506–511

    Article  CAS  PubMed  Google Scholar 

  22. Kisely S, Smith M, Lawrence D, Cox M, Campbell LA, Maaten S (2007) Inequitable access for mentally ill patients to some medically necessary procedures. CMAJ 176(6):779–784

    Article  PubMed Central  PubMed  Google Scholar 

  23. Laursen TM, Munk-Olsen T, Agerbo E, Gasse C, Mortensen PB (2009) Somatic hospital contacts, invasive cardiac procedures, and mortality from heart disease in patients with severe mental disorder. Arch Gen Psychiatry 66(7):713–720

    Article  PubMed  Google Scholar 

  24. Lawrence DM, Holman CD, Jablensky AV, Hobbs MS (2003) Death rate from ischaemic heart disease in Western Australian psychiatric patients 1980–1998. Br J Psychiatry 182:31–36

    Article  PubMed  Google Scholar 

  25. Chang CK, Hayes RD, Perera G, Broadbent MT, Fernandes AC, Lee WE, Hotopf M, Stewart R (2011) Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London. PLoS ONE 6(5):e19590

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Batty GD, Hamer M, Der G (2012) Does somatic illness explain the association between common mental disorder and elevated mortality? Findings from extended follow-up of study members in the UK Health and Lifestyle Survey. J Epidemiol Community Health 66(7):647–649

    Article  PubMed  Google Scholar 

  27. Nordentoft M, Wahlbeck K, Hallgren J, Westman J, Osby U, Alinaghizadeh H, Gissler M, Laursen TM (2013) Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and Sweden. PLoS ONE 8(1):e55176

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Breslow NE, Day NE (1987) Statistical methods in cancer research. Volume II—the design and analysis of cohort studies. IARC Sci Publ 82:1–406

    Google Scholar 

  29. Bouye J, Hémon D, Cordier S (1993) Epidémiologie-principes et méthodes quantitatives. INSERM, Paris

  30. Bruce ML, Leaf PJ, Rozal GP, Florio L, Hoff RA (1994) Psychiatric status and 9-year mortality data in the New Haven Epidemiologic Catchment Area Study. Am J Psychiatry 151(5):716–721

    Article  CAS  PubMed  Google Scholar 

  31. Honkonen H, Mattila AK, Lehtinen K, Elo T, Haataja R, Joukamaa M (2008) Mortality of Finnish acute psychiatric hospital patients. Soc Psychiatry Psychiatr Epidemiol 43(8):660–666

    Article  PubMed  Google Scholar 

  32. Kisely S, Smith M, Lawrence D, Maaten S (2005) Mortality in individuals who have had psychiatric treatment: population-based study in Nova Scotia. Br J Psychiatry 187:552–558

    Article  PubMed  Google Scholar 

  33. Chang CK, Hayes RD, Broadbent M, Fernandes AC, Lee W, Hotopf M, Stewart R (2010) All-cause mortality among people with serious mental illness (SMI), substance use disorders, and depressive disorders in southeast London: a cohort study. BMC Psychiatry 10:77

    Article  PubMed Central  PubMed  Google Scholar 

  34. Druss BG, Bradford WD, Rosenheck RA, Radford MJ, Krumholz HM (2001) Quality of medical care and excess mortality in older patients with mental disorders. Arch Gen Psychiatry 58(6):565–572

    Article  CAS  PubMed  Google Scholar 

  35. Brown S (1997) Excess mortality of schizophrenia. A meta-analysis. Br J Psychiatry 171:502–508

    Article  CAS  PubMed  Google Scholar 

  36. Hitosugi M (1999) Retrospective analysis of the forensic autopsy cases of psychiatric patients. Med Sci Law 39(4):293–301

    CAS  PubMed  Google Scholar 

  37. Ruschena D, Mullen PE, Burgess P, Cordner SM, Barry-Walsh J, Drummer OH, Palmer S, Browne C, Wallace C (1998) Sudden death in psychiatric patients. Br J Psychiatry 172:331–336

    Article  CAS  PubMed  Google Scholar 

  38. Brown S, Inskip H, Barraclough B (2000) Causes of the excess mortality of schizophrenia. Br J Psychiatry 177:212–217

    Article  CAS  PubMed  Google Scholar 

  39. Crisanti AS, Love EJ (1999) Mortality among involuntarily admitted psychiatric patients: a survival analysis. Soc Psychiatry Psychiatr Epidemiol 34(12):627–633

    Article  CAS  PubMed  Google Scholar 

  40. Saha S, Chant D, McGrath J (2007) A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 64(10):1123–1131

    Article  PubMed  Google Scholar 

  41. Lawrence D, Holman CD, Jablensky AV, Fuller SA, Stoney AJ (2001) Increasing rates of suicide in Western Australian psychiatric patients: a record linkage study. Acta Psychiatr Scand 104(6):443–451

    Article  CAS  PubMed  Google Scholar 

  42. Leucht S, Burkard T, Henderson J, Maj M, Sartorius N (2007) Physical illness and schizophrenia: a review of the literature. Acta Psychiatr Scand 116(5):317–333

    Article  CAS  PubMed  Google Scholar 

  43. Osborn DP, Limburg H, Walters K, Petersen I, King M, Green J, Watson J, Nazareth I (2013) Relative incidence of common cancers in people with severe mental illness. Cohort study in the United Kingdom THIN primary care database. Schizophr Res 143(1):44–49

    Article  PubMed  Google Scholar 

  44. Kisely S, Sadek J, MacKenzie A, Lawrence D, Campbell LA (2008) Excess cancer mortality in psychiatric patients. Can J Psychiatry 53(11):753–761

    PubMed  Google Scholar 

  45. Auquier P, Lancon C, Rouillon F, Lader M, Holmes C (2006) Mortality in schizophrenia. Pharmacoepidemiol Drug Saf 15(12):873–879

    Article  PubMed  Google Scholar 

  46. Brown S, Birtwistle J, Roe L, Thompson C (1999) The unhealthy lifestyle of people with schizophrenia. Psychol Med 29(3):697–701

    Article  CAS  PubMed  Google Scholar 

  47. Fagiolini A, Goracci A (2009) The effects of undertreated chronic medical illnesses in patients with severe mental disorders. J Clin Psychiatry 70(Suppl 3):22–29

    Article  PubMed  Google Scholar 

  48. Osby U, Correia N, Brandt L, Ekbom A, Sparen P (2000) Time trends in schizophrenia mortality in Stockholm county, Sweden: cohort study. BMJ 321(7259):483–484

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  49. Robson D, Gray R (2007) Serious mental illness and physical health problems: a discussion paper. Int J Nurs Stud 44(3):457–466

    Article  PubMed  Google Scholar 

  50. Osborn D, Levy G, Nazareth I, King M (2008) Suicide and severe mental illnesses. Cohort study within the UK general practice research database. Schizophr Res 99(1–3):134–138

    Article  PubMed  Google Scholar 

  51. Colton CW, Manderscheid RW (2006) Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states. Prev Chronic Dis 3(2):A42

    PubMed  Google Scholar 

  52. Hannerz H, Borga P, Borritz M (2001) Life expectancies for individuals with psychiatric diagnoses. Public Health 115(5):328–337

    Article  CAS  PubMed  Google Scholar 

  53. Chwastiak LA, Tek C (2009) The unchanging mortality gap for people with schizophrenia. Lancet 374(9690):590–592

    Article  PubMed  Google Scholar 

  54. Dembling BP, Chen DT, Vachon L (1999) Life expectancy and causes of death in a population treated for serious mental illness. Psychiatr Serv 50(8):1036–1042

    Article  CAS  PubMed  Google Scholar 

  55. Gray R, Hardy S, Anderson KH (2009) Physical health and severe mental illness: if we don’t do something about it, who will? Int J Ment Health Nurs 18(5):299–300

    Article  PubMed  Google Scholar 

  56. Vaiva G, Vaiva G, Ducrocq F, Meyer P, Mathieu D, Philippe A, Libersa C, Goudemand M (2006) Effect of telephone contact on further suicide attempts in patients discharged from an emergency department: randomised controlled study. BMJ 332(7552):1241–1245

    Article  PubMed Central  PubMed  Google Scholar 

  57. van der Sande R, Buskens E, Allart E, van der Graaf Y, van Engeland H (1997) Psychosocial intervention following suicide attempt: a systematic review of treatment interventions. Acta Psychiatr Scand 96(1):43–50

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors wish to thank all hospital directors of Nord-Pas-De-Calais region who have financially supported this work. The authors also want to thank Christian Porteaux, computer scientist, for having collected data.

Conflict of interest

The authors declare that they have no conflict of interest.

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Correspondence to Claire-Lise Charrel.

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Charrel, CL., Plancke, L., Genin, M. et al. Mortality of people suffering from mental illness: a study of a cohort of patients hospitalised in psychiatry in the North of France. Soc Psychiatry Psychiatr Epidemiol 50, 269–277 (2015). https://doi.org/10.1007/s00127-014-0913-1

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  • DOI: https://doi.org/10.1007/s00127-014-0913-1

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