Summary
As they age, BHE/Cdb rats develop impaired glucose tolerance. We hypothesized that this intolerance is associated with a previously reported base substitution in the mitochondrial genome. A new screening test was devised to identify animals with the mutation. These animals were bred to animals without the mutation. The progeny were then tested for the presence of the mutation and their glucose tolerance at 100 and 300 days of age. Phenotype and genotype were found to be closely linked and we conclude that the mutation in the mitochondrial ATPase 6 gene explains the age related impaired glucose tolerance in BHE/Cdb rats. [Diabetologia (1999) 42: 35–40]
Article PDF
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 12 December 1997 and in final revised form: 31 July 1998
Rights and permissions
About this article
Cite this article
Mathews, C., McGraw, R., Dean, R. et al. Inheritance of a mitochondrial DNA defect and impaired glucose tolerance in BHE/Cdb rats. Diabetologia 42, 35–40 (1999). https://doi.org/10.1007/s001250051109
Issue Date:
DOI: https://doi.org/10.1007/s001250051109