References
Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292:1389–1394
Zulewski H, Abraham EJ, Gerlach MJ et al. (2001) Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50:521–533
Hanley NA, Ball SG, Clement-Jones M et al. (1999) Expression of steroidogenic factor 1 and Wilms’ tumour 1 during early human gonadal development and sex determination. Mech Dev 87:175–180
Wroblewski J, Engstrom M, Edwall-Arvidsson C, Sjoberg G, Sejersen T, Lendahl U (1997) Distribution of nestin in the developing mouse limb bud in vivo and in micro-mass cultures of cells isolated from limb buds. Differentiation 61:151–159
Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P (2000) Early pattern of differentiation in the human pancreas. Diabetes 49:225–232
Lendahl U, Zimmerman LB, McKay RD (1990) CNS stem cells express a new class of intermediate filament protein. Cell 60:585–595
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Piper, K., Ball, S.G., Turnpenny, L.W. et al. Beta-cell differentiation during human development does not rely on nestin-positive precursors: implications for stem cell-derived replacement therapy. Diabetologia 45, 1045–1047 (2002). https://doi.org/10.1007/s00125-002-0864-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00125-002-0864-z