Skip to main content
SpringerLink
Log in

Modifizierbare und nichtmodifizierbare Risikofaktoren für Urolithiasis

Modifiable and non-modifiable risk factors for urolithiasis

  • Leitthema
  • Published:
Der Urologe Aims and scope Submit manuscript

Zusammenfassung

Die Kenntnis der Risikofaktoren für eine Urolithiasis bildet die Basis für eine suffiziente Metaphylaxe und Reduktion von Rezidivereignissen. Zu den modifizierbaren Risikofaktoren gehören neben der Ernährung und Trinkmenge auch Beruf, Umweltfaktoren, die Anzahl der Schwangerschaften sowie das intestinale Mikrobiom. Assoziierte Erkrankungen, durch deren Behandlung das Erkrankungs- und Rezidivrisiko für Urolithiasis gesenkt werden kann, betreffen insbesondere die verschiedenen Ausprägungen des metabolischen Syndroms. Die Kenntnis nichtmodifizierbarer Risikofaktoren wie Geschlecht, Ethnie, positive Familienanamnese sowie spezifische genetische Defekte und Polymorphismen des Calcium- und Phosphathaushalts ermöglichen eine personalisierte Beratung und Nachsorge der betreffenden Patienten.

Abstract

Knowledge of the risk factors for urolithiasis is the key for sufficient metaphylaxis and reduction of recurrence events. Modifiable risk factors include diet, drink quantity, occupation, environmental factors, number of pregnancies and the intestinal microbiome. The treatment of associated diseases, such as the various manifestations of metabolic syndrome can reduce the risk for urolithiasis and recurrences. Knowledge of non-modifiable risk factors, such as gender, ethnicity, positive family history as well as specific genetic defects and polymorphisms of the calcium and phosphate balance enables personalized counselling and follow-up of affected patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

AOR:

„Adjusted odds ratio“ (korrigierte Odds Ratio)

CAC:

„Coronary artery calcification“ (Verkalkung der Koronarien)

EPIC-Oxford:

Britische Subkohorte der European Prospective Investigation into Cancer and Nutrition

HR:

Hazard Ratio

MET:

„Metabolic equivalent of task“ (metabolisches Äquivalent)

NHANES:

National Health and Nutrition Examination Survey

NHS:

„Nurses’ health study“

OR:

Odds Ratio

Oxf:

Oxalobacter formigenes

RR:

Relatives Risiko

SCCS:

„Southern community cohort study“

SES:

„Socioeconomic status“ (sozioökonomischer Status)

Literatur

  1. Alelign T, Petros B (2018) Kidney stone disease: an update on current concepts. Adv Urol 2018:1–12

    Article  Google Scholar 

  2. Angell J, Bryant M, Tu H et al (2012) Association of depression and urolithiasis. Urology 79:518–525

    Article  Google Scholar 

  3. Aune D, Mahamat-Saleh Y, Norat T et al (2018) Body fatness, diabetes, physical activity and risk of kidney stones: a systematic review and meta-analysis of cohort studies. Eur J Epidemiol 33:1033–1047

    Article  CAS  Google Scholar 

  4. Bao Y, Wei Q (2012) Water for preventing urinary stones. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.cd004292.pub3

    Article  PubMed  Google Scholar 

  5. Borghi L, Meschi T, Amato F et al (1996) Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5‑year randomized prospective study. J Urol 155:839–843

    Article  CAS  Google Scholar 

  6. Chen M‑H, Weng S‑F, Hsu C‑C et al (2016) Urolithiasis risk: a comparison between healthcare providers and the general population. BMC Health Serv Res 16:273

    Article  Google Scholar 

  7. Colditz GA, Hankinson SE (2005) The Nurses’ Health Study: lifestyle and health among women. Nat Rev Cancer 5:388–396

    Article  CAS  Google Scholar 

  8. Curhan GC, Willett WC, Rimm EB et al (1996) Prospective study of beverage use and the risk of kidney stones. Am J Epidemiol 143:240–247

    Article  CAS  Google Scholar 

  9. Curhan GC, Willett WC, Rimm EB et al (1993) A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med 328:833–838

    Article  CAS  Google Scholar 

  10. Curhan GC, Willett WC, Speizer FE et al (1997) Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women. Ann Intern Med 126:497–504

    Article  CAS  Google Scholar 

  11. Faller N, Dhayat NA, Fuster DG (2019) Nephrolithiasis secondary to inherited defects in the thick ascending loop of henle and connecting tubules. Urolithiasis 47:43–56

    Article  Google Scholar 

  12. Ferraro PM, Mandel EI, Curhan GC et al (2016) Dietary protein and potassium, diet-dependent net acid load, and risk of incident kidney stones. Clin J Am Soc Nephrol 11:1834–1844

    Article  CAS  Google Scholar 

  13. Ferraro PM, Taylor EN, Gambaro G et al (2013) Soda and other beverages and the risk of kidney stones. Clin J Am Soc Nephrol 8:1389–1395

    Article  Google Scholar 

  14. Hemminki K, Hemminki O, Försti A et al (2018) Familial risks in urolithiasis in the population of Sweden. BJU Int 121:479–485

    Article  Google Scholar 

  15. Hsi RS, Kabagambe EK, Shu X et al (2018) Race- and sex-related differences in nephrolithiasis risk among blacks and whites in the southern community cohort study. Urology 118:36–42

    Article  Google Scholar 

  16. Hsi RS, Spieker AJ, Stoller ML et al (2016) Coronary artery calcium score and association with recurrent nephrolithiasis: the multi-ethnic study of atherosclerosis. J Urol 195:971–976

    Article  CAS  Google Scholar 

  17. Kim S, Chang Y, Sung E et al (2018) Association between sonographically diagnosed nephrolithiasis and subclinical coronary artery calcification in adults. Am J Kidney Dis 71:35–41

    Article  Google Scholar 

  18. Kohjimoto Y, Sasaki Y, Iguchi M et al (2013) Association of metabolic syndrome traits and severity of kidney stones: results from a nationwide survey on urolithiasis in Japan. Am J Kidney Dis 61:923–929

    Article  Google Scholar 

  19. Lien C‑S, Huang C‑P, Chung C‑J et al (2015) Increased risk of anxiety among patients with urolithiasis: a nationwide population-based cohort study. Int J Urol 22:937–942

    Article  Google Scholar 

  20. Linder BJ, Rangel LJ, Krambeck AE (2013) The effect of work location on urolithiasis in health care professionals. Urolithiasis 41:327–331

    Article  Google Scholar 

  21. Mehta M, Goldfarb DS, Nazzal L (2016) The role of the microbiome in kidney stone formation. Int J Surg 36:607–612

    Article  Google Scholar 

  22. Mente A, Honey RJDA, Mclaughlin JR et al (2007) Ethnic differences in relative risk of idiopathic calcium nephrolithiasis in North America. J Urol 178:1992–1997

    Article  Google Scholar 

  23. Najem GR, Seebode JJ, Samady AJ et al (1997) Stressful life events and risk of symptomatic kidney stones. Int J Epidemiol 26:1017–1023

    Article  CAS  Google Scholar 

  24. Oliveira B, Unwin R, Walsh SB (2019) Inherited proximal tubular disorders and nephrolithiasis. Urolithiasis 47:35–42

    Article  Google Scholar 

  25. Palsson R, Indridason OS, Edvardsson VO et al (2019) Genetics of common complex kidney stone disease: insights from genome-wide association studies. Urolithiasis 47:11–21

    Article  Google Scholar 

  26. Reinstatler L, Khaleel S, Pais VM (2017) Association of pregnancy with stone formation among women in the United States: a NHANES analysis 2007 to 2012. J Urol 198:389–393

    Article  Google Scholar 

  27. Saint-Elie DT, Patel PV, Healy KA et al (2010) The impact of income and education on dietary habits in stone formers. Urology 76:307–313

    Article  Google Scholar 

  28. Shuster J, Jenkins A, Logan C et al (1992) Soft drink consumption and urinary stone recurrence: a randomized prevention trial. J Clin Epidemiol 45:911–916

    Article  CAS  Google Scholar 

  29. Siener R, Hesse A (2003) Fluid intake and epidemiology of urolithiasis. Eur J Clin Nutr 57:S47–S51

    Article  Google Scholar 

  30. Sorensen MD, Chi T, Shara NM et al (2014) Activity, energy intake, obesity, and the risk of incident kidney stones in postmenopausal women: a report from the Women’s Health Initiative. J Am Soc Nephrol 25:362–369

    Article  Google Scholar 

  31. Tasian GE, Jemielita T, Goldfarb DS et al (2018) Oral antibiotic exposure and kidney stone disease. J Am Soc Nephrol 29:1731

    Article  Google Scholar 

  32. Taylor EN, Curhan GC (2013) Dietary calcium from dairy and nondairy sources, and risk of symptomatic kidney stones. J Urol 190:1255–1259

    Article  CAS  Google Scholar 

  33. Taylor EN, Curhan GC (2008) Fructose consumption and the risk of kidney stones. Kidney Int 73:207–212

    Article  CAS  Google Scholar 

  34. Taylor EN, Curhan GC (2007) Oxalate intake and the risk for nephrolithiasis. J Am Soc Nephrol 18:2198–2204

    Article  CAS  Google Scholar 

  35. Taylor EN, Fung TT, Curhan GC (2009) DASH-style diet associates with reduced risk for kidney stones. J Am Soc Nephrol 20:2253–2259

    Article  CAS  Google Scholar 

  36. Taylor EN, Stampfer MJ, Curhan GC (2005) Diabetes mellitus and the risk of nephrolithiasis. Kidney Int 68:1230–1235

    Article  Google Scholar 

  37. Tundo G, Khaleel S, Pais VM (2018) Gender equivalence in the prevalence of nephrolithiasis among adults younger than 50 years in the United States. J Urol 200:1273–1277

    Article  Google Scholar 

  38. Turney BW, Appleby PN, Reynard JM et al (2014) Diet and risk of kidney stones in the oxford cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). Eur J Epidemiol 29:363–369

    Article  CAS  Google Scholar 

  39. Vezzoli G, Macrina L, Magni G et al (2019) Calcium-sensing receptor: evidence and hypothesis for its role in nephrolithiasis. Urolithiasis 47:23–33

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Urologie, Universitätsklinikum Freiburg, Hugstetter Str. 55, 79106, Freiburg, Deutschland

    F. Praus & M. Schönthaler

Authors
  1. F. Praus
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Schönthaler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to F. Praus.

Ethics declarations

Interessenkonflikt

F. Praus und M. Schönthaler geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Praus, F., Schönthaler, M. Modifizierbare und nichtmodifizierbare Risikofaktoren für Urolithiasis. Urologe 58, 1281–1288 (2019). https://doi.org/10.1007/s00120-019-01031-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00120-019-01031-9

Schlüsselwörter

Keywords

Search

Navigation