Skip to main content
Log in

Nebenwirkungen der medikamentösen Behandlung der erektilen Dysfunktion

Side effects of erectile dysfunction drug treatment

  • Leitthema
  • Published:
Der Urologe Aims and scope Submit manuscript

Zusammenfassung

Die Therapie der erektilen Dysfunktion hat sich im Laufe der letzten Jahrzehnte grundlegend gewandelt. Die Phosphodiesterase-5-Inhibitoren (PDE-5-Inhibitoren) sind die First-line-Therapie. Zugelassen in Europa sind Sildenafil, Tadalafil, Vardenafil und Avanafil. Die Substanzen zeigen ähnliche Erfolgs- und Nebenwirkungspotentiale. Die absolute Kontraindikation ist die Einnahme von Nitraten. Durch diese therapeutische Vielfalt sollte es möglich sein, unter Zusammenarbeit aller ärztlichen Fachdisziplinen, unseren Patienten ein zufriedenstellendes Sexualleben zu ermöglichen bzw. wiederherzustellen.

Abstract

Due to the large number of drugs now available, the therapy of erectile dysfunction has changed profoundly in recent decades. The phosphodiesterase type 5 inhibitors (PDE5-i): sildenafil, taldalafil, vardenafil, and avanafil are EMA European Medicines Agency approved and show similar adverse events and success rates. The absolute contraindication is the simultaneous use of nitrates. Despite this wide variety of options, therapy of erectile dysfunction should be performed in an individually adapted manner. The exact patient’s history, physical examination, collaboration of medical disciplines, and choice of therapy will offer every patient the possibility to achieve or regain a satisfying sexual life.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Stief CG, Truss MC, Becker AJ, Kuczyk M, Jonas U (2000) Pharmakologische Therapiemöglichkeiten der Erektionstörung. Dtsch Arztebl 97:457–460

    Google Scholar 

  2. Montorsi F, Deho F, Salonia A, Cestari A, Guazzoni G, Rigatti P, Stief CG (2003) Pharmacological management of erectile dysfunction. BJU Int 91:446–454

    Article  CAS  PubMed  Google Scholar 

  3. Porst H (1996) The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience. J Urol 155:802–815

    Article  CAS  PubMed  Google Scholar 

  4. Montorsi F, Salonia A, Zanoni M, Pompa P, Cestari A, Guazzoni G, Barbieri L, Rigatti P (2002) Current status of penile therapy. Int J Impot Res 14(Suppl.1):70–81

    Article  Google Scholar 

  5. Leungwattanakij S, Flynn V, Hellstrom JG (2001) Intracavernosal injection and intraurethral therapy for erectile dysfunction. Urol Clin N Am 28:343–354

    Article  CAS  Google Scholar 

  6. McMahon CG (2002) Topiglan macrochem. Curr Opin Investig Drugs 3:602–6006

    CAS  PubMed  Google Scholar 

  7. McVary KT, Polepalle S, Riggi S, Pelham RW (1999) Topical prostaglandin E1 SEPA gel for the treatment of erectile dysfunction. J Urol 162:726–731

    Article  CAS  PubMed  Google Scholar 

  8. Guay AT, Perez JB, Jacobson J, Newton RA (2001) Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors. J Androl 22:793–797

    CAS  PubMed  Google Scholar 

  9. Sperling H, Michel MC, Rübben H (1999) Sildenafil (Viagra) Verträglichkeit, Kontraindikationen, Arzneimittelintraktionen. Urologe A 38:124–127

    Article  CAS  PubMed  Google Scholar 

  10. Mydlo JH, Volpe MA, Macchia RJ (2000) Results from different patient populations using combined therapy with alprostadil and sildenafil: predictors of satisfaction. BJU Int 86:469–473

    Article  CAS  PubMed  Google Scholar 

  11. Arruda-Olson AM, Mahoney DW, Nehra A, Leckel M, Pellikka PA (2002) Cardivascular effects of sildenafil during exercise in men with known or probable coronary artery disease. JAMA 287:719–725

    Article  CAS  PubMed  Google Scholar 

  12. Fox K, Thadani U, Ma PTS, Nash SD, Keltai M (2001) Time to onset of limiting angina during treadmill exercise in men with erectile dysfunction and stable chronic angina: effect of sildenafil citrate. Circulation 104(Suppl.):2841

    Google Scholar 

  13. Mitka M (2000) Some men who take viagra die – why? JAMA 285:590–593

    Google Scholar 

  14. Shakir SAW, Wilton LV, Bshier A, Layton D, Heeley E (2001) Cardiovascular events in users of sildenafil: result from first phase of prescription event monitoring in England. BMJ 322:651–652

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Spivack AP, Peterson CA, Cowley C, Hall M, Nemo KJ, Stephens D, Tam PY, Todd LK, Place VA (1997) Long-term safety profile of transurethral alprostadil for the treatment of erectile dysfunction. J Urol 157:A792

    Google Scholar 

  16. Porst H (2002) IC351 (tadalafil, cialis): update on clinical experience. Int J Impot Res 14(Suppl.1):57–64

    Article  Google Scholar 

  17. Shabsigh R, Padma-Nathan H, Gittleman M (2000) Intracavernous alprostadil alfadex is more efficious, better tolerated and preferred over intraurethral alprostadil plus optional ACTIS: a comparative, randomised, crossover, multicenter study. Urology 55:109–113

    Article  CAS  PubMed  Google Scholar 

  18. Dell’Atti L (2015) Tadalafil once daily and intralesional verapamil injection: a new therapeutic direction in Peyronie’s disease. Urol Ann 2015:345–349

    Google Scholar 

  19. Pomeranz HD, Smith KH, Hart WM (2002) Sildenafil-associated nonarteritic anterior Ischemic optic neuropathy. Ophthalmology 109:584–587

    Article  PubMed  Google Scholar 

  20. Burnett AL, Anele UA, Truehart IN, Strouse JJ, Casella JF (2014) Randomized controlled trial of sildenafil for preventing recurrent ischemic priapism in sickle cell disease. Am J Med 127:664–668

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Sanford M (2013) Avanafil: a review of its use in patients with erectile dysfunction. Drugs Aging 30(10):853–862

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to H. Sperling.

Ethics declarations

Interessenkonflikt

H. Sperling: Vortragshonorare bzw. Berater und Studientätigkeit bei Lilly, Pfizer und Jenapharm, Bayer.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sperling, H. Nebenwirkungen der medikamentösen Behandlung der erektilen Dysfunktion. Urologe 56, 451–455 (2017). https://doi.org/10.1007/s00120-017-0341-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00120-017-0341-4

Schlüsselwörter

Keywords

Navigation