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Varikozele bei Jugendlichen

Varicocele in adolescents

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Zusammenfassung

Bei rund 15% aller adoleszenten Jungen findet sich eine überwiegend links lokalisierte Varikozele testis. Welchen Krankheitswert diese jedoch hat und welcher dieser Jungen tatsächlich von einer späteren Infertilität bedroht ist, ist nicht geklärt. Die Erforschung der Pathophysiologie, der Auswirkungen einer operativen oder radiologischen Therapie und potentieller Prädiktoren einer Schädigung der Spermatogenese sind nicht abgeschlossen. Die Indikation zur Therapie wird derzeit bei oft fehlender Verfügbarkeit von Ejakulatwerten v. a. an einer Differenz der Hodenvolumina festgemacht. Allerdings korrelieren die Hodenvolumina nicht zwingend mit einer späteren (In-)Fertilität, so dass dieser Surrogatparameter kritisch zu hinterfragen ist, zumal die Hälfte der Varikozelenträger in der Jugend eine Hodenvolumenzunahme ohne jede Intervention erfahren.

Abstract

Testicular varicocele is present in 15 % of adolescent boys. The very impact of this pathology and who will be at risk of developing into infertility remains unclear. Research on the pathophysiology, results of surgical or radiological interventions and potential predictors for long-term impairment of spermatogenesis and thus fertility is still ongoing. Indications for treatment are mainly based on differences in testicular volumes as semen parameters are most often not available; however, whether testicular volume is a valuable prognostic parameter for later fertility remains questionable. Approximately 50 % of adolescent patients with varicocele experience spontaneous increase of testicular volume without any intervention.

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Literatur

  1. Abdelrahim F, Mostafa A, Hamdy A et al (1993) Testicular morphology and function in varicocele patients: pre-operative and post-operative histopathology. Br J Urol 72:643–647

    Article  PubMed  CAS  Google Scholar 

  2. Akbay E, Cayan S, Doruk E et al (2000) The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 86:490–493

    Article  PubMed  CAS  Google Scholar 

  3. Alukal JP, Zurakowski D, Atala A et al (2005) Testicular hypotrophy does not correlate with grade of adolescent varicocele. J Urol 174:2367–2370

    Article  PubMed  Google Scholar 

  4. Baazeem A, Belzile E, Ciampi A et al (2011) Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur Urol 60:796–808

    Article  PubMed  Google Scholar 

  5. Baek M, Park SW, Moon KH et al (2011) Nationwide survey to evaluate the prevalence of varicoceles in South Korean middle school boys: a population based study. Int J Urol 18:55–60

    Article  PubMed  Google Scholar 

  6. Barroso U Jr, Andrade DM, Novaes H et al (2009) Surgical treatment of varicocele in children with open and laparoscopic Palomo technique: a systematic review of the literature. J Urol 181:2724–2728

    Article  PubMed  Google Scholar 

  7. Basar MM, Kisa U, Tuglu D et al (2010) The effect of varicocele on seminal plasma and serum inhibin-B levels in adolescent and adult men. Int Urol Nephrol 42:47–51

    Article  PubMed  CAS  Google Scholar 

  8. Borruto FA, Impellizzeri P, Antonuccio P et al (2010) Laparoscopic vs open varicocelectomy in children and adolescents: review of the recent literature and meta-analysis. J Pediatr Surg 45:2464–2469

    Article  PubMed  Google Scholar 

  9. Braedel HU, Steffens J, Ziegler M et al (1994) A possible ontogenic etiology for idiopathic left varicocele. J Urol 151:62–66

    PubMed  CAS  Google Scholar 

  10. Cavarzere P, Sulpasso M, Maines E et al (2011) Serum inhibin B levels before and after varicocelectomy in early adolescence. J Endocrinol Invest 34:265–267

    Google Scholar 

  11. Cayan S, Akbay E, Bozlu M et al (2002) The effect of varicocele repair on testicular volume in children and adolescents with varicocele. J Urol 168:731–734

    Article  PubMed  Google Scholar 

  12. Cayan S, Shavakhabov S, Kadioğlu A (2009) Treatment of palpable varicocele: review in infertile men: a meta-analysis to define the best technique. J Androl 30:33–40

    Article  PubMed  Google Scholar 

  13. Decastro GJ, Shabsigh A, Poon SA et al (2009) Adolescent varicocelectomy – Is the potential for catch-up growth related to age and/or Tanner stage? J Urol 181:322–327

    Article  PubMed  Google Scholar 

  14. Del Giudice PT, Lima SB, Cenedeze MA et al (2010) Expression of the Fas-ligand gene in ejaculated sperm from adolescents with and without varicocele. J Assist Reprod Genet 27:103–109

    Article  Google Scholar 

  15. Glassberg KI, Badalato GM, Poon SA et al (2011) Evaluation and management of the persistent/recurrent varicocele. Urology 77:1194–1198

    Article  PubMed  Google Scholar 

  16. Graif M, Hauser R, Hirshebein A et al (2000) Varicocele and the testicular-renal venous route: hemodynamic Doppler sonographic investigation. J Ultrasound Med 19:627–631

    PubMed  CAS  Google Scholar 

  17. Greenfield SP, Seville P, Wan J (2002) Experience with varicoceles in children and young adults. J Urol 168:1684–1688

    Article  PubMed  Google Scholar 

  18. Guarino N, Tadini B, Bianchi M (2003) The adolescent varicocele: the crucial role of hormonal tests in selecting patients with testicular dysfunction. J Pediatr Surg 38:120–123

    Article  PubMed  Google Scholar 

  19. Keene DJ, Sajad Y, Rakoczy G, Cervellione RM (2012) Testicular volume and semen parameters in patients aged 12–17 years with idiopathic varicocele. J Pediatr Surg 47:383–385

    Article  PubMed  Google Scholar 

  20. Kliesch S (2008) Kontra Varikozelentherapie. Aktuelle Urol 39:263–264

    Google Scholar 

  21. Korets R, Woldu SL, Nees SN et al (2011) Testicular symmetry and adolescent Varicocele – does it need followup? J Urol 186:1614–1619

    Article  PubMed  Google Scholar 

  22. Ku JH, Kim SW, Park K, Paick JS (2005) Benefits of microsurgical repair of adolescent varicocele: comparison of semen parameters in fertile and infertile adults with varicocele. Urology 65:554–558

    Article  PubMed  Google Scholar 

  23. Lacerda JI, Del Giudice PT, Silva BF da et al (2011) Adolescent varicocele: improved sperm function after varicocelectomy. Fertil Steril 95:994–999

    Article  PubMed  Google Scholar 

  24. Laven JS, Haans LC, Mali WP et al (1992) Effects of varicocele treatment in adolescents: a randomized study. Fertil Steril 58:756–762

    PubMed  CAS  Google Scholar 

  25. Li F, Chiba K, Yamaguchi K et al (2012) Effect of varicocelectomy on testicular volume in children and adolescents: a meta-analysis. Urology 79:1340–1345

    Article  PubMed  Google Scholar 

  26. Nieschlag E, Behre HM, Wieacker P et al (2009) Störungen im Bereich der Testes. In: Nieschlag E, Behre HM, Nieschlag S (Hrsg) Andrologie – Grundlagen und Klinik der reproduktiven Gesundheit des Mannes, 3. Aufl. Springer, Berlin Heidelberg New York

  27. Paduch DA, Niedzielski J (1996) Semen analysis in young men with varicocele: preliminary study. J Urol 156:788–790

    Article  PubMed  CAS  Google Scholar 

  28. Paduch DA, Skoog SJ (2001) Current management of adolescent varicocele. Rev Urol 3:120–133

    PubMed  CAS  Google Scholar 

  29. Pfeiffer D, Berger J, Schoop C, Tauber R (2008) Varikozele und pubertäres Hodenwachstum. Urologe 47:59–64

    Article  PubMed  CAS  Google Scholar 

  30. Podkamenev VV, Stalmakhovich VN, Urkov PS et al (2002) Laparoscopic surgery for pediatric varicoceles: Randomized controlled trial. J Pediatr Surg 37:727–729

    Article  PubMed  CAS  Google Scholar 

  31. Preston MA, Carnat T, Flood T et al (2008) Conservative management of adolescent varicoceles: a retrospective review. Urology 72:77–78

    Article  PubMed  Google Scholar 

  32. Romeo C, Arrigo T, Impellizzeri P et al (2007) Altered serum inhibin B levels in adolescents with varicocele. J Pediatr Surg 42:390–394

    Article  PubMed  Google Scholar 

  33. Shridharani A, Lockwood G, Sandlow J (2012) Varicocelectomy in the treatment of testicular pain: a review. Curr Opin Urol 22:499–506

    Article  PubMed  Google Scholar 

  34. Sinanoglu O, Eyyupoglu SE, Ekici S (2012) Ipsilateral testicular catch-up growth rate following microsurgical inguinal adolescent varicocelectomy. ScientificWorldJournal (Article ID 356374, 4 pages, doi:10.1100/2012/356374)

  35. Spinelli C, Di Giacomo M, Lo Piccolo R et al (2010) The role of testicular volume in adolescents with varicocele: the better way and time of surgical treatment. J Urol 184:1722–1726

    Article  PubMed  Google Scholar 

  36. Van Batavia JP, Woldu SL, Raimondi PM et al (2010) Adolescent varicocele: influence of Tanner stage at presentation on the presence, development, worsening and/or improvement of testicular hypotrophy without surgical intervention. J Urol 184:1727–1732

    Article  Google Scholar 

  37. Wang YJ, Zhang RQ, Lin YJ et al (2012) Relationship between varicocele and sperm DNA damage and the effect of varicocele repair: a meta-analysis. Reprod Biomed Online 25:307–314

    Article  PubMed  CAS  Google Scholar 

  38. Woldu SL, Van Batavia JP, Poon SA et al (2010) Is adolescent varicocelectomy safe after previous inguinal surgery? J Urol 184(Suppl):1716–1721

    Article  PubMed  Google Scholar 

  39. World Health Organization (1999) Laboratory manual for the examination of human semen and sperm–cervical mucus interaction, 4. edn. Cambridge University Press, Cambridge

  40. World Health Organization (2010) WHO laboratory manual for the examination and processing of human semen, 5. edn. WHO Press, Geneva

  41. Yamamoto M, Hibi H, Katsuno S, Miyake K (1995) Effects of varicocelectomy on testis volume and semen parameters in adolescents: a randomized prospective study. Nagoya J Med Sci 58:127–132

    PubMed  CAS  Google Scholar 

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Czeloth, K., Kälble, T. & Kliesch, S. Varikozele bei Jugendlichen. Urologe 52, 48–53 (2013). https://doi.org/10.1007/s00120-012-3080-6

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