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Zur Therapie des fortgeschrittenen Peniskarzinoms

Brauchen wir neue Wege in der Chemotherapie?

Treatment of advanced penile cancer

Do we need new methods for chemotherapy?

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Zusammenfassung

Das Peniskarzinom ist ein Plattenepithelkarzinom mit hoher Letalität im fortgeschrittenen Stadium. Es existieren nur wenige Daten aus relativ kleinen Serien zur systemischen Therapie. Die etablierten Therapieschemata sind gekennzeichnet durch hohe Toxizität und geringe Effektivität. Diese desolate Situation lässt sich nur durch systematische Studien mit neuen Therapieprotokollen ändern. Erste Ergebnisse mit neuen Substanzen sind durchaus Erfolg versprechend, gegenwärtig aber überwiegend auf die Darstellung einzelner Fälle beschränkt.

Abstract

Penile cancer is a squamous epithelial neoplasia with a very high mortality in advanced stages. Only few series with small patient numbers have addressed the systemic treatment of advanced penile carcinoma. Established regimens are characterized by high toxicity and poor efficacy. Due to the relative paucity of data, recommendations and guidelines on the treatment of metastatic penile carcinoma are vague. New approaches and large-scale studies that will allow better definition of adequate and more effective treatment options are needed. Encouraging results with newer chemotherapeutic agents are at present mainly anecdotal but are still encouraging.

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Authors and Affiliations

  1. Klinik und Poliklinik für Urologie, Universität Rostock, Ernst-Heyedemann-Straße 6, 18055, Rostock, Deutschland

    C. Protzel & O.W. Hakenberg

  2. Urologische Klinik, Universitätsklinikum, Greifswald, Deutschland

    H.-J. Klebingat

Authors
  1. C. Protzel
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  2. H.-J. Klebingat
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  3. O.W. Hakenberg
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Correspondence to O.W. Hakenberg.

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Protzel, C., Klebingat, HJ. & Hakenberg, O. Zur Therapie des fortgeschrittenen Peniskarzinoms. Urologe 47, 1229–1232 (2008). https://doi.org/10.1007/s00120-008-1841-z

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  • DOI: https://doi.org/10.1007/s00120-008-1841-z

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