Zusammenfassung
Beim Peniskarzinom ist die Lebensqualität der Patienten besonders eng mit dem Organerhalt verknüpft. Vor diesem Hintergrund wurden für diese seltene jedoch aggressive Tumorentität verschiedene Operationsverfahren wie die mikrographische Chirurgie, die Lasertherapie und die Glansektomie entwickelt. Diese sollen dem Patienten ein Höchstmaß an onkologischer Sicherheit bei gleichzeitigem Erhalt der Sexualfunktion bieten. Der vorliegende Artikel gibt eine Übersicht über die etablierten Behandlungsoptionen sowie die Indikation und Grenzen der organerhaltenden Therapie des Peniskarzinoms.
Abstract
In patients with penile cancer health-related quality of life is closely related to organ-sparing surgery. To achieve an ideally suited treatment modality for this rare but aggressive tumor entity different operating techniques like micrographic surgery, laser treatment, and glansectomy were developed. These should offer optimal oncological treatment while preserving sexual function. This article gives an overview of indications and limits of organ-sparing treatment in penile cancer.
This is a preview of subscription content, log in via an institution to check access.
Literatur
Brown MD, Zachary CB, Grekin RC et al. (1987) Penile tumors: their management by Mohs micrographic surgery. J Dermatol Surg Oncol 13: 1163–1167
Burgers JK, Badalament RA, Drago JR (1992) Penile cancer. Clinical presentation, diagnosis, and staging. Urol Clin North Am 19: 247–256
Crook J, Grimard L, Tsihlias J et al. (2002) Interstitial brachytherapy for penile cancer: an alternative to amputation. J Urol 167: 506–511
Cubilla AL, Meijer CJ, Young RH (2000) Morphological features of epithelial abnormalities and precancerous lesions of the penis. Scand J Urol Nephrol 205(Suppl): 215–219
Delannes M, Malavaud B, Douchez J et al. (1992) Iridium-192 interstitial therapy for squamous cell carcinoma of the penis. Int J Radiat Oncol Biol Phys 24: 479–483
Demkow T (1999) The treatment of penile carcinoma: experience in 64 cases. Int Urol Nephrol 31: 525–531
Frimberger D, Hungerhuber E, Zaak D et al. (2002) Penile carcinoma. Is Nd: YAG laser therapy radical enough? J Urol 168: 2418–2421
Frimberger D, Schneede P, Hungerhuber E et al. (2002) Autofluorescence and 5-aminolevulinic acid induced fluorescence diagnosis of penile carcinoma – new techniques to monitor Nd: YAG laser therapy. Urol Res 30: 295–300
Hakenberg OW, Wirth MP (1999) Issues in the treatment of penile carcinoma. A short review. Urol Int 62: 229–233
Horenblas S, Kroger R, Gallee MP et al. (1994) Ultrasound in squamous cell carcinoma of the penis; a useful addition to clinical staging? A comparison of ultrasound with histopathology. Urology 43: 702–707
Horenblas S, Van Tinteren H (1994) Squamous cell carcinoma of the penis. IV. Prognostic factors of survival: analysis of tumor, nodes and metastasis classification system. J Urol 151: 1239–1243
Horenblas S, Van Tinteren H, Delemarre JF et al. (1992) Squamous cell carcinoma of the penis. II. Treatment of the primary tumor. J Urol 147: 1533–1538
Lont AP, Besnard AP, Gallee MP et al. (2003) A comparison of physical examination and imaging in determining the extent of primary penile carcinoma. BJU Int 91: 493–495
Mahlmann B, Doehn C, Feyerabend T (2001) Radiotherapy of penis carcinoma. Urologe A 40: 308–312
Mcdougal WS (2005) Phallic preserving surgery in patients with invasive squamous cell carcinoma of the penis. J Urol 174: 2218–2220
Minhas S, Kayes O, Hegarty P et al. (2005) What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int 96: 1040–1043
Mohs FE, Snow SN, Larson PO (1992) Mohs micrographic surgery for penile tumors. Urol Clin North Am 19: 291–304
Ornellas AA, Seixas AL, Marota A et al. (1994) Surgical treatment of invasive squamous cell carcinoma of the penis: retrospective analysis of 350 cases. J Urol 151: 1244–1249
Palminteri E, Berdondini E, Lazzeri M et al. (2007) Resurfacing and reconstruction of the glans penis. Eur Urol 52: 893–898
Persson B, Sjodin JG, Holmberg L et al. (2007) The National Penile Cancer Register in Sweden 2000–2003. Scand J Urol Nephrol 41: 278–282
Pietrzak P, Corbishley C, Watkin N (2004) Organ-sparing surgery for invasive penile cancer: early follow-up data. BJU Int 94: 1253–1257
Pizzocaro G, Piva L, Bandieramonte G et al. (1997) Up-to-date management of carcinoma of the penis. Eur Urol 32: 5–15
Prowse DM, Ktori EN, Chandrasekaran D et al. (2008) Human papillomavirus-associated increase in p16INK4A expression in penile lichen sclerosus and squamous cell carcinoma. Br J Dermatol 158: 261–265
Romero FR, Romero KR, Mattos MA et al. (2005) Sexual function after partial penectomy for penile cancer. Urology 66: 1292–1295
Shindel AW, Mann MW, Lev RY et al. (2007) Mohs micrographic surgery for penile cancer: management and long-term followup. J Urol 178: 1980–1985
Smith Y, Hadway P, Biedrzycki O et al. (2007) Reconstructive surgery for invasive squamous carcinoma of the glans penis. Eur Urol 52: 1179–1185
Solsona E, Algaba F, Horenblas S et al. (2004) EAU Guidelines on Penile Cancer. Eur Urol 46: 1–8
Solsona E, Iborra I, Rubio J et al. (2001) Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes. J Urol 165: 1506–1509
Windahl T, Skeppner E, Andersson SO et al. (2004) Sexual function and satisfaction in men after laser treatment for penile carcinoma. J Urol 172: 648–651
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Schlenker, B., Gratzke, C., Tilki, D. et al. Organerhaltende Chirurgie des Peniskarzinoms. Urologe 47, 803–808 (2008). https://doi.org/10.1007/s00120-008-1710-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00120-008-1710-9