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Die Kryoablation des Prostatakarzinoms

Cryoablation of prostate cancer

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Zusammenfassung

Die kontinuierliche technische Entwicklung über mehr als ein halbes Jahrhundert und daraus resultierende bessere klinische Ergebnisse bei geringerer Nebenwirkungsrate haben die Kryoablation der Prostata zu einer echten Alternative bei der Behandlung des lokalisierten Prostatakarzinoms (PCA) bei selektionierten Patienten werden lassen. Die heutige Form der Kryotherapie hat fast nichts mehr mit der in den 1970er Jahren entwickelten und in den 1990er Jahren verbesserten Variante gemeinsam. Die heutige minimale Invasivität und hohe Wirksamkeit bei High-risk-Karzinomen zum einen und Versagen anderer therapeutischer Modalitäten zum anderen ergeben ein Anwendungsspektrum bei absoluter oder relativer Kontraindikation zur radikalen Operation. In der Salvagesituation bei noch lokalisiertem PCA ist die Kryoablation derzeit Therapie der Wahl. Nicht zuletzt wurde dieser Stellenwert durch eine Standardisierung der Prozedur, exakte Definition des Ablaufs und strukturierte Trainingsprogramme erreicht.

Abstract

Because of continuous technical development for more than half a century, followed by better clinical results with minimal side effects, cryoablation of the prostate for localized prostate cancer has evolved as a true alternative therapeutic option in selected cases. Today’s form of cryotherapy has almost nothing in common with those versions established in the 1970s and further developed in the 1990s. Nowadays it shows minimal invasiveness and high efficacy for treatment of high-risk carcinomas and failures of other therapeutic modalities. Cryoablation of the prostate is indicated if there are absolute or relative contraindications for radical surgery. In localized prostate cancer, cryoablation is the therapy of choice for salvage cases; standardisation of the procedure, definition of freeze-thaw cycles, and structured training programs have led to this status.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung hin: Trainer für Kryotherapie der 3. Generation. Trotz des möglichen Interessenkonflikts ist der Beitrag unabhängig und produktneutral.

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Authors and Affiliations

  1. Klinik für Urologie und Kinderurologie, Krankenhaus Nordwest, Stiftung Hospital zum Heiligen Geist, Steinbacher Hohl 2–26, 60488, Frankfurt/Main, Deutschland

    U.K.F. Witzsch, K. Skriapas & E. Becht

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  1. U.K.F. Witzsch
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  2. K. Skriapas
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  3. E. Becht
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Correspondence to U.K.F. Witzsch.

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Witzsch, U., Skriapas, K. & Becht, E. Die Kryoablation des Prostatakarzinoms. Urologe 47, 449–454 (2008). https://doi.org/10.1007/s00120-008-1660-2

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