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Anwendung von Tissue-Microarrays für die Diagnose, Prognose und Therapieentscheidung beim Nierenzellkarzinom

Application of tissue microarrays for the diagnosis, prognosis and therapeutic decision making in renal cell carcinoma

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Zusammenfassung

Die Tissue-Microarray-Technik (TMA) stellt eine moderne Hochdurchflussanalyse-Methode dar, die zeit- und kostengünstige Untersuchung großer Patientenkollektive hinsichtlich des Vorliegens von Alterationen auf DNA/RNA- bzw. Proteinebene ermöglicht. Diese Arbeit soll Einsatzmöglichkeiten für die Verwendung dieser Methode am Nierenzellkarzinom im Sinne einer Translationsmedizin — „vom Labor in die Klinik“ darlegen, insbesondere wird auf den Nutzen in Diagnose, Prognose und Therapie am Nierenzellkarzinom eingegangen.

Abstract

The tissue microarray technique (TMA) represents a powerful diagnostic “high-throughput” tool to analyse DNA/RNA or protein alterations in large patient cohorts in a time and cost effective way. This review focuses on the clinical application of TMA in renal cell carcinoma in modern “translational” medicine — “from bench to bedside”. In particular, the advantages of TMA for diagnosis, prognosis and decisions for therapy will be considered in relation to renal cell cancer.

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Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.

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Authors and Affiliations

  1. Abteilung für Urologie, Eberhard Karls-Universität, Tübingen

    A. S. Merseburger, J. Hennenlotter, D. Schilling, K. D. Sievert & M. A. Kuczyk

  2. Urologische Universitätsklinik und Poliklinik, Universität Ulm

    R. Küfer

  3. Klinik für Urologie, Eberhard Karls-Universität UKT, Hoppe-Seyler-Straße 3, 72076, Tübingen

    A. S. Merseburger

Authors
  1. A. S. Merseburger
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  2. J. Hennenlotter
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  3. D. Schilling
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  4. K. D. Sievert
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  5. R. Küfer
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  6. M. A. Kuczyk
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Corresponding author

Correspondence to A. S. Merseburger.

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Merseburger, A.S., Hennenlotter, J., Schilling, D. et al. Anwendung von Tissue-Microarrays für die Diagnose, Prognose und Therapieentscheidung beim Nierenzellkarzinom. Urologe 45, 323–327 (2006). https://doi.org/10.1007/s00120-006-1005-y

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  • DOI: https://doi.org/10.1007/s00120-006-1005-y

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