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T1-Maps und O2-verstärkte MRT der erkrankten Lunge

Emphysem, Fibrose, Mukoviszidose

T1 maps and O2-enhanced MRT of the diseased lung

Emphysema, fibrosis, mucoviscidosis

  • MRT der Lunge
  • Published:
Der Radiologe Aims and scope Submit manuscript

Schlussfolgerung

T1-Mapping und sauerstoffverstärkte MRT sind viel versprechende neue Methoden in der funktionellen Lungenbildgebung, die komplementär zur morphologischen Bildgebung wertvolle Zusatzinformationen erbringen.

Die primäre Funktion der Lunge ist der Gasaustausch, der Transport von Sauerstoff spielt in der Physiologie und Pathophysiologie der Lunge eine wesentliche Rolle. Molekularer Sauerstoff besitzt schwache paramagnetische Eigenschaften. Daher führt eine Erhöhung seiner Konzentration zur Verkürzung der T1-Zeit und somit zur Signalanhebung auf T1-gewichteten Bildern. Die Darstellung der T1-Zeiten mit Hilfe von Parameter-Maps erlaubt tiefere Einblicke in die Relaxationsmechanismen der Lunge. Aus während der Inhalation verschiedener O2-Konzentrationen erstellten T1-Maps können Sauerstofftransferfunktionen (OTF) als Maß des lokalen Sauerstofftransports erstellt werden. Mit T1-gewichteten Single-shot-TSE-Sequenzen können auch Effekte, die nach Inhalation von reinem Sauerstoff auftreten, erfasst werden. Der Durchschnitt der T1-Werte in Inspiration war 1199±117 ms, in Exspiration 1333±167 ms. T1-Maps von Patienten mit Emphysem und Lungenfibrose zeigten ein grundsätzlich unterschiedliches Verhalten: Die sauerstoffverstärkte MRT ergab eine reduzierte Diffusionskapazität/einen eingeschränkten Sauerstofftransport bei Patienten mit Emphysem und Mukoviszidose.

Abstract

Purpose

Gas exchange is the primary function of the lung and the transport of oxygen plays a key role in pulmonary physiology and pathophysiology.

Materials and Methods

Molecular oxygen is weakly paramagnetic, so that an increase in oxygen concentration results in shortening T1 relaxation time and thus increasing signal intensity in T1 weighted images. The calculation of parameter maps may allow deeper insights into relaxation mechanisms. T1 maps based on a snapshot FLASH sequence obtained during the inhalation of various oxygen concentrations allow the creation of an oxygen transfer function, providing a measurement of local oxygen transfer. T1 weighted single shot TSE sequences demonstrate the signal changing effects during inhalation of pure oxygen.

Results

The average of the mean T1 values over the entire lung during inspiration was 1,199±117 ms, the average of these values during expiration was 1,333±167 ms. T1 maps of patients with emphysema and lung fibrosis show fundamentally different values and respiratory dependence compared to healthy individuals. Oxygen enhanced MR has the potential to assess reduced diffusion capacity and decreased transport of oxygen in patients with emphysema and cystic fibrosis.

Discussion

Results published in the literature indicate that T1 mapping and oxygen enhanced MR are promising new methods in functional imaging of the lung.

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Authors and Affiliations

  1. Universitätsklinik für Radiodiagnostik, Medizinische Universität Wien

    A. Stadler & A. A. Bankier

  2. Universitätsklinik für Innere Medizin IV, Medizinische Universität Wien

    L. Stiebellehner

  3. Physikalisches Institut EP 5, Universität , Würzburg

    P. M. Jakob & J. F. T. Arnold

  4. Universitätsklinik für Radiodiagnostik, Medizinische Universität Wien, Währinger Gürtel 18–20, 1090 , Wien, Österreich

    A. Stadler

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  1. A. Stadler
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  2. L. Stiebellehner
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  3. P. M. Jakob
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  5. A. A. Bankier
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Correspondence to A. Stadler.

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Stadler, A., Stiebellehner, L., Jakob, P.M. et al. T1-Maps und O2-verstärkte MRT der erkrankten Lunge. Radiologe 46, 282–289 (2006). https://doi.org/10.1007/s00117-006-1346-y

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  • DOI: https://doi.org/10.1007/s00117-006-1346-y

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