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Aktueller Stand der MRT-Diagnostik mit leberspezifischen Kontrastmitteln

Gd-EOB-DTPA und Gd-BOPTA

Current status of MRI diagnostics with liver-specific contrast agents

Gd-EOB-DTPA and Gd-BOPTA

  • Leberdiagnostik, Teil 1
  • Published:
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Zusammenfassung

Die Kontrastmittel Gd-EOB-DTPA und Gd-BOPTA können per Bolusinjektion administriert werden und sind geeignet, sowohl als Vaskularisationsmarker als auch Marker der hepatobiliären Exkretion in der MRT verwendet zu werden. In dieser Übersichtsarbeit werden spezifische Eigenschaften der Kontrastmittel und der Stand der klinischen Entwicklung dargestellt. Im Vergleich zur CT und zur MRT mit unspezifischen extrazellulären Gd-Chelaten ergeben sich Vorteile der leberspezifischen Kontrastmittel für die Differenzierung unklarer Leberläsionen, für die Anhebung der Detektionsrate sowie die Untersuchung des Gallengangsystems.

Abstract

The contrast agents Gd-EOB-DTPA and Gd-BOPTA can be administered by bolus injection and are appropriate for use in MRI both as vascularization markers and markers of hepatobiliary excretion. This contribution presents an overview of the specific characteristics of contrast media and the status of clinical development. In comparison to CT and to MRI with unspecific extracellular Gd-chelates, liver-specific contrast agents offer advantages in differentiating unclear liver lesions, increasing the detection rate, and examining the bile duct system.

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Der korrespondierende Autor weist auf eine Verbindung mit folgender Firma/Firmen hin: Unterstützung einer Phase III Studie durch Schering AG

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Authors and Affiliations

  1. Klinik und Poliklinik für Strahlenheilkunde, Campus-Virchow-Klinikum der Charité-Universitätsmedizin Berlin

    C. Stroszczynski, G. Gaffke, M. Gnauck, F. Streitparth, G. Wieners & E. Lopez-Häninnen

  2. Klinik und Poliklinik für Strahlenheilkunde, Campus-Virchow-Klinikum der Charité-Universitätsmedizin, Augustenburger Platz 1, 13353 , Berlin

    C. Stroszczynski

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  1. C. Stroszczynski
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  2. G. Gaffke
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  3. M. Gnauck
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  4. F. Streitparth
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  5. G. Wieners
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  6. E. Lopez-Häninnen
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Correspondence to C. Stroszczynski.

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Stroszczynski, C., Gaffke, G., Gnauck, M. et al. Aktueller Stand der MRT-Diagnostik mit leberspezifischen Kontrastmitteln. Radiologe 44, 1185–1191 (2004). https://doi.org/10.1007/s00117-004-1134-5

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  • DOI: https://doi.org/10.1007/s00117-004-1134-5

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