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Die Bedeutung depressiver Syndrome bei beginnender Demenz vom Alzheimer-Typ im höheren Lebensalter

The importance of depressive syndromes for incipient Alzheimer-Type dementia in advanced age

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Zusammenfassung

Ausgehend von epidemiologischen Befunden, die ein bei Depression erhöhtes Risiko zeigen, an einer Demenz zu erkranken, diskutieren wir neuere Befunde zum Einfluss depressiver Erkrankungen im höheren Lebensalter auf Kognition und den Zusammenhang zwischen depressiven Syndromen und beginnender Alzheimer-Demenz. Dabei referieren wir den Stand der Forschung zu möglichen Mechanismen, wie depressive Erkrankungen kognitive Defizite hervorrufen und mit der Alzheimer-Krankheit einhergehen können. Die beschriebenen Befunde unterstreichen die zentrale Bedeutung depressiver Erkrankungen für die Diagnostik und Therapie psychischer Erkrankungen des höheren Lebensalters.

Abstract

Based on epidemiological data on the risk for dementia conveyed by depression, we report recent findings on the effects of depressive disorders on cognition in later life and its relationship to incipient Alzheimer’s disease. We review the current literature on possible mechanisms underlying the depression-dementia association. The findings summarized in this review underline the central importance of depressive disorders for the diagnosis and treatment of psychiatric disorders in later life.

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  1. Klinik für Psychiatrie und Psychotherapie, Charité Campus Mitte, Berlin, Deutschland

    M.A. Rapp, R. Hellweg & A. Heinz

  2. Gerontopsychiatrisches Zentrum, Psychiatrische Universitätsklinik der Charité im St. Hedwig Krankenhaus, Campus Mitte, Große Hamburger Str. 5-11, 10115, Berlin, Deutschland

    M.A. Rapp

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  1. M.A. Rapp
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  2. R. Hellweg
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  3. A. Heinz
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Correspondence to M.A. Rapp.

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Rapp, M., Hellweg, R. & Heinz, A. Die Bedeutung depressiver Syndrome bei beginnender Demenz vom Alzheimer-Typ im höheren Lebensalter. Nervenarzt 82, 1140–1144 (2011). https://doi.org/10.1007/s00115-010-3129-y

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