Skip to main content
SpringerLink
Log in

Unterschiedliche Manifestationsformen der zerebralen Nokardiose

Different manifestations of the cerebral nocardiosis

  • Originalien
  • Published:
Der Nervenarzt Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Zusammenfassung

Nokardien verursachen häufig pulmonale Infektionen, können aber auch in seltenen Fällen zum Befall des zentralen Nervensystems (ZNS) führen. Zur Behandlung zerebraler Nokardiosen gibt es nur wenig klinische Erfahrungen. Wir möchten zwei Fälle mit unterschiedlicher zerebraler Beteiligung im Rahmen einer Nokardiose vorstellen. Eine zerebrale Nokardiose kann in der kranialen Bildgebung sehr unterschiedliche Bilder von kleinsten multiplen Abszessen bis zu solitären großen Abszessen bieten. Trotz ihres insgesamt seltenen Vorkommens ist die Nokardiose eine wichtige Differenzialdiagnose bei abszendierenden Prozessen im zentralen Nervensystem.

Summary

Nocardial infections affect mainly the respiratory tract but also can attack the CNS. Clinical experience with cerebral nocardiosis is very limited. We present two patients with very different cerebral affections due to nocardiosis. Cerebral nocardial infections can cause both multiple small abscesses and single large abscesses in the human brain. Despite the rare incidence of cerebral nocardiosis, it is an important differential diagnosis of expansive processes and abscesses in the CNS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2

Literatur

  1. Beaman BL, Beaman L (1994) Nocardia species: host-parasite relationship. Clin Microbiol Rev 7: 213–264

    PubMed  CAS  Google Scholar 

  2. Chedid MBF, Chedid MF, Porto NS et al (2007) Nocardial infection: Report of 22 cases. Rev Inst Med Trop Sao Paulo 49:239–246

    PubMed  Google Scholar 

  3. Eisenblatter M, Disko U, Stoltenburg-Didinger G et al (2002) Isolation of nocardia paucivorans from the cerebrospinal fluid of a patient with relapse of cerebral nocardiosis. J Clin Microbiol 40:3532–3534

    Article  PubMed  CAS  Google Scholar 

  4. Elmaci I, Senday D, Silav G et al (2007) Nocardial cerebral abscess associated with mycetoma, pneumonia and membranoproliferative glomerulonephritis. J Clin Microbiol 45:2072–2074

    Article  PubMed  Google Scholar 

  5. Everett CM, Dhillon H, Samarasinghe D et al (2006) A case of cerebral nocardiosis following brief immunosuppression. Eur J Neurol 13:431–432

    Article  PubMed  CAS  Google Scholar 

  6. Gray TJ, Serisier DJ, Gilpin CM et al (2007) Nocardia paucivorans – a cause of disseminated nocardiosis. A review. J Infect 54:95–98

    Article  Google Scholar 

  7. Kennedy KJ, Chung KH, Bowden FJ et al (2007) A cluster of nocardial brain abscesses. A review. Surg Neurol 68:43–49

    Article  PubMed  Google Scholar 

  8. Khan SN, Sanche SE, Robinson CA, Pirouzmand F (2006) N. paucivorans infection presenting as a brain abscess. Can J Neurol Sci 33:426–427

    PubMed  Google Scholar 

  9. Kilincer C, Hamamcioglu MK, Simsek O et al (2006) Nocardial brain abscess: review of clinical management. J Clin Neurosci 13(4): 481–485

    Article  PubMed  Google Scholar 

  10. Lerner PI (1996) Nocardiosis. Clin Inf Dis 22:891–905

    CAS  Google Scholar 

  11. Loeffler JM, Bodmer T, Zimmerli W, Leib SL (2001) Nocardial brain abscess: observation of treatment strategies and outcome in Switzerland from 1992 to 1999. Infection 29:337–341

    Article  PubMed  CAS  Google Scholar 

  12. Mamelak AN, Obana WG, Flahery JF, Rosenblum ML (1994) Nocardial brain abszess: treatment strategies and factors influencing outcome. Neurosurgery 35:622–631

    Article  PubMed  CAS  Google Scholar 

  13. McNeil MM, Brown JM (1994) The medically important aerobic actinomycetes: epidemiology and microbiology. Clin Microbiol Rev 7:357–417

    PubMed  CAS  Google Scholar 

  14. Pintado V, Gomez-Mampaso E, Fortun J et al. (2002) Infection with Nocardia species: clinical spectrum of disease and species distribution in Madrid, Spain 1978–2001. Infection 30:338–340

    Article  PubMed  CAS  Google Scholar 

  15. Sabuncuoglu H,Cibali Acikgo ZZ, Caydere M et al (2004). Nocardia farcinica brain abscess: a case report and review of the literature. Neurocirugia 15:600–603

    PubMed  CAS  Google Scholar 

  16. Schaal, KP, Lee HJ (1992) Actinomycete infections in humans: a review. Gene 115:201–211

    Article  PubMed  CAS  Google Scholar 

  17. Uttamachandani RB, Daikos GL, Reyes RR (1994) Nocardiosis in 30 patients with advanced HIV infection: clinical features and outcome. Clin Infect Dis 18:348–353

    Google Scholar 

  18. Wenger PN, Brown JM, McNeil MM, Jarvis WR (1998) Nocardia farcinica sternotomy site infections in patients following open heart surgery. J Infect Dis 178:1539–1543

    Article  PubMed  CAS  Google Scholar 

  19. Yassin AF, Rainey FA, Burghardt J et al (2000) Nocardia paucivorans sp. Int J Syst Evol Microbiol 2:803–809

    Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Neurologische Klinik, Universitätsklinikum, Pauwelsstraße 30, 52074, Aachen, Deutschland

    D. Buelte, J. Noth & R. Gobbelé

  2. Klinik für Neuroradiologie, Universitätsklinikum, Aachen, Deutschland

    M. Mull

  3. Klinik für Neuropathologie, Universitätsklinikum, Aachen, Deutschland

    B. Sellhaus

  4. Medizinische Klinik III, Universitätsklinikum, Aachen, Deutschland

    A. Koch

  5. Klinik für Neurochirurgie, Universitätsklinikum, Aachen, Deutschland

    M. Queider

  6. Zentralbereich für Krankenhaushygiene und Infektiologie, Universitätsklinikum Aachen, Aachen, Deutschland

    F. Hünger

Authors
  1. D. Buelte
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Noth
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Mull
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Sellhaus
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Koch
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Queider
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F. Hünger
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. R. Gobbelé
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. Buelte.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Buelte, D., Noth, J., Mull, M. et al. Unterschiedliche Manifestationsformen der zerebralen Nokardiose. Nervenarzt 79, 1432–1435 (2008). https://doi.org/10.1007/s00115-008-2601-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00115-008-2601-4

Schlüsselwörter

Keywords

Search

Navigation