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Poststroke-Depression

Klinik, Epidemiologie, Therapie, pathophysiologische Konzepte

Post-stroke depression

Clinical aspects, epidemiology, therapy, and pathophysiology

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Zusammenfassung

Poststroke-Depression (PSD) ist die häufigste psychiatrische Komplikation nach Schlaganfall (bis zu 50%) und ist sowohl für schlaganfallassoziierte Morbidität als auch Mortalität relevant. Vermutlich wird die PSD in der klinischen Praxis zu selten diagnostiziert und häufig nicht adäquat behandelt. Diese Übersichtsarbeit fasst den gegenwärtigen Kenntnisstand zu Epidemiologie, Klinik, Prädisposition und Risikofaktoren, Therapie und Prophylaxe sowie pathophysiologischen Konzepten zusammen.

Summary

Post-stroke depression (PSD) is the most frequent psychiatric complication following ischemic stroke, affecting up to 50% of all such patients. Moreover, PSD is associated with increased morbidity and mortality following ischemic stroke. In clinical practice, PSD is underdiagnosed and many affected patients do not receive adequate treatment. This review article summarizes current knowledge regarding epidemiogy, clinical features, risk factors and predisposition, therapy, and prophylaxis of PSD.

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Interessenkonflikt

Die Forschergruppe „Interdisziplinäre Schlaganfallforschung“ wird von der Volkswagen-Stiftung gefördert (Lichtenberg-Professur, M.E.). Trotz des möglichen Interessenkonfliktes ist der Beitrag unabhängig und produktneutral.

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  1. Klinik und Poliklinik für Psychiatrie, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin

    G. Kronenberg

  2. Klinik und Polikinik für Neurologie, Charité Campus Mitte, Schumannstraße 20/21, 10117, Berlin

    G. Kronenberg, J. Katchanov &  M. Endres

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  1. G. Kronenberg
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  2. J. Katchanov
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  3. M. Endres
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Correspondence to M. Endres.

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Kronenberg, G., Katchanov, J. & Endres, M. Poststroke-Depression. Nervenarzt 77, 1176–1185 (2006). https://doi.org/10.1007/s00115-006-2130-y

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