Skip to main content
SpringerLink
Log in

VGKC-Antikörper-assoziierte limbische Enzephalitis

Limbic encephalitis associated with autoantibodies against voltage-gated potassium channels

  • Kasuistiken
  • Published:
Der Nervenarzt Aims and scope Submit manuscript

Zusammenfassung

Seit der Erstbeschreibung der „limbische Enzephalitis“ (LE) 1960/1968 wurden verschiedene Subformen dieses klinisch-neuropathologischen Syndroms identifiziert. Die bekannteste Form ist die paraneoplastische LE. In jüngerer Zeit wurden auch nichtparaneoplastische Formen beschrieben, zuletzt in Assoziation mit Autoantikörpern gegen spannungsabhängige Kaliumkanäle. Die Kasuistik beschreibt die diagnostische Aufarbeitung eines solchen Falles sowie das für diese Subform der LE offenbar typische gute Ansprechen auf eine Langzeitimmuntherapie.

Summary

Since the initial description of limbic encephalitis (LE) in 1960/1968, several subforms of this clinico-neuropathological syndrome have been identified. The best known is paraneoplastic LE. However, nonparaneoplastic forms have been reported, too. Very recently, autoantibodies against voltage-gated potassium channels have been described in association with LE. The diagnostic workup of such a case and the apparently typical good response to long-term immunotherapy of this LE subform are described.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Arain A, Abou-Khalil B, Moses H (2001) Hashimoto’s encephalopathy: documentation of mesial temporal seizure origin by ictal EEG. Seizure 10:438–441

    CAS  PubMed  Google Scholar 

  2. Buckley C, Oger J, Clover L et al. (2001) Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann Neurol 50:73–78

    CAS  PubMed  Google Scholar 

  3. Corsellis JA, Goldberg GJ, Norton AR (1968) “Limbic encephalitis” and its association with carcinoma. Brain 91:481–496

    CAS  PubMed  Google Scholar 

  4. Gultekin SH, Rosenfeld MR, Voltz R et al. (2000) Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain 123:1481–1494

    Article  PubMed  Google Scholar 

  5. Pozo-Rosich P, Clover L, Saiz A et al. (2003) Voltage-gated potassium channel antibodies in limbic encephalitis. Ann Neurol 54:530–533

    CAS  PubMed  Google Scholar 

  6. Schäuble B, Castillo PR, Boeve BF et al. (2003) EEG findings in steroid-responsive encephalopathy associated with autoimmune thyroiditis. Clin Neurophysiol 114:32–37

    Article  PubMed  Google Scholar 

  7. Stübgen JP (1998) Nervous system lupus mimics limbic encephalitis. Lupus 7:557–560

    PubMed  Google Scholar 

  8. Thieben MJ, Lennon VA, Boeve BF et al. (2004) Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. Neurology 62:1177–1182

    CAS  PubMed  Google Scholar 

  9. Vincent A, Buckley C, Schott JM et al. (2004) Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 127:701–712

    PubMed  Google Scholar 

  10. Wainwright MS, Martin PL, Morse RP et al. (2001) Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Ann Neurol 50:612–619

    CAS  PubMed  Google Scholar 

Download references

Danksagung

Wir danken Dr. Frédéric Mataigne (Neuroradiologie, Centre Hospitalier de Luxembourg) für die Überlassung von MRT-Aufnahmen.

Interessenkonflikt

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

Author information

Authors and Affiliations

  1. Klinik für Epileptologie, Universität Bonn

    B. M. Soeder, C. E. Elger &  C. G. Bien

  2. Radiologische Klinik, Universität Bonn

    H. Urbach

  3. Département des Neurosciences, Centre Hospitalier de Luxembourg

    S. Beyenburg

  4. Klinik für Epileptologie, Universität Bonn, Sigmund-Freud-Straße 25, 53105, Bonn, Deutschland

    C. G. Bien

Authors
  1. B. M. Soeder
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Urbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. E. Elger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. G. Bien
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Beyenburg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. G. Bien.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Soeder, B.M., Urbach, H., Elger, C.E. et al. VGKC-Antikörper-assoziierte limbische Enzephalitis . Nervenarzt 76, 760–762 (2005). https://doi.org/10.1007/s00115-004-1844-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00115-004-1844-y

Schlüsselwörter

Keywords

Search

Navigation