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Neue Einblicke in die Immunpathogenese der Multiplen Sklerose

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Zusammenfassung

Die Multiple Sklerose (MS) ist eine chronisch-entzündliche und demyelinisierende Erkrankung des zentralen Nervensystems (ZNS). Obgleich das Immunsystem eine wichtige Rolle in der Pathogenese der Erkrankung einnimmt, sind die Zielantigene der Immunantwort bisher noch weitgehend unbekannt und die zur Läsion führenden Pathomechanismen nur teilweise verstanden. Kürzlich veröffentlichte Studien haben jedoch wesentlich zum besseren Verständnis der Erkrankung beigetragen und neue Einsichten hinsichtlich Ätiologie und Pathogenese der MS geliefert. Der Artikel gibt einen Überblick über die Rolle des Immunsystems bei der Manifestation und Entfaltung der Erkrankung unter Einbeziehung bestehender und neuer pathogenetischer Konzepte. Abschließend diskutieren wir—unter Berücksichtigung neuer wissenschaftlicher Methoden—zukünftige Forschungsstrategien zur Entschlüsselung der Ätiologie und Pathogenese der MS.

Summary

Multiple sclerosis is a chronic inflammatory and demyelinating disease of the central nervous system. Although the immune system seems to play an important role in its pathogenesis, target antigens are still uncertain and pathways leading to tissue destruction have not been fully elucidated. Recent studies have significantly contributed to better understanding of the disease process and broadened our view on possible scenarios of disease initiation and progression. Here, we review the role of the immune system in the manifestation and evolution of MS and discuss different pathogenetic concepts. We conclude with an outlook on future strategies for identifying the cause of MS.

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Danksagung

Die Autoren danken ihren Patienten für ihren Betrag zur klinischen Forschung. Wir danken außerdem der gemeinnützigen Hertie-Stiftung für die kontinuierliche Unterstützung der Forschungspojekte. Bernhard Hemmer ist ein Heisenberg-Stipendiat der Deutschen Forschungsgemeinschaft.

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Authors and Affiliations

  1. Neurologische Universitätsklinik, Philipps-Universität Marburg

    B. Rosche &  B. Hemmer

  2. Neurologische Universitätsklinik, Heinrich-Heine-Universität Düsseldorf

    B. Kieseier & H.-P. Hartung

  3. Neurologische Universitätsklinik, Philipps-Universität, Rudolf-Bultmann-Straße 12, 35033 , Marburg

    B. Hemmer

Authors
  1. B. Rosche
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  2. B. Kieseier
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  3. H.-P. Hartung
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  4. B. Hemmer
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Rosche, B., Kieseier, B., Hartung, HP. et al. Neue Einblicke in die Immunpathogenese der Multiplen Sklerose. Nervenarzt 74, 654–663 (2003). https://doi.org/10.1007/s00115-003-1534-1

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  • DOI: https://doi.org/10.1007/s00115-003-1534-1

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