Zusammenfassung
Hintergrund
Kürzlich wurde ein Zusammenhang zwischen tödlich verlaufenden Pneumonien bei immunkompetenten jugendlichen Patienten (Medianalter 14,8 Jahre) und dem Nachweis von Staphylococcus-aureus-Stämmen, die das Gen für Panton-Valentine-Leukozidin (PVL) tragen, beschrieben.
Kasuistik
Wir berichten über ein 12-jähriges Mädchen, das 3 Tage nach Beginn eines fieberhaften Infektes mit Tachydyspnoe stationär aufgenommen wurde. Hämatologisch fiel eine Leukopenie auf. Röntgenologisch zeigte sich eine Pleuropneumonie. Das Krankheitsbild verschlechterte sich foudroyant, sodass nach 10 Tagen der Hirntod diagnostiziert wurde.
Ergebnisse
Prä- und postmortal konnte aus relevanten Materialien ein PVL-positiver Staphylococcus-aureus-Stamm isoliert werden.
Abstract
Background
Recently, an association between lethal pneumonia in young immunocompetent patients (median age 14.8 years) and the presence of Staphylococcus aureus strains carrying the gene for Panton-Valentine leukocidine (PVL) was described.
Patient
Here we report on a 12-year old girl, who was admitted to the hospital 3 days after the onset of a febrile infection with tachydyspnea. Leukopenia was found haematologically. Radiologically, pleural effusion and pulmonary infiltrates were demonstrated. The progression of the disease was rapid, leading to cerebral death within 10 days of diagnosis.
Results
A PVL-positive S. aureus strain was cultured from relevant samples both pre and post mortem.
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Hörnig-Franz, I., Kahl, B.C., Tebbe, W. et al. Nekrotisierende Pneumonie mit Staphylococcus aureus (pvl-Gen positiv). Monatsschr Kinderheilkd 155 (Suppl 1), S10–S15 (2007). https://doi.org/10.1007/s00112-005-1105-6
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DOI: https://doi.org/10.1007/s00112-005-1105-6