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Protein acetylation: a novel modus of obesity regulation

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Abstract

Obesity is a chronic epidemic disease worldwide which has become one of the important public health issues. It is a process that excessive accumulation of adipose tissue caused by long-term energy intake exceeding energy expenditure. So far, the prevention and treatment strategies of obesity on individuals and population have not been successful in the long term. Acetylation is one of the most common ways of protein post-translational modification (PTM). It exists on thousands of non-histone proteins in almost every cell chamber. It has many influences on protein levels and metabolome levels, which is involved in a variety of metabolic reactions, including sugar metabolism, tricarboxylic acid cycle, and fatty acid metabolism, which are closely related to biological activities. Studies have shown that protein acetylation levels are dynamically regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs). Protein acetylation modifies protein-protein and protein-DNA interactions and regulates the activity of enzymes or cytokines which is related to obesity in order to participate in the occurrence and treatment of obesity-related metabolic diseases. Therefore, we speculated that acetylation was likely to become effective means of controlling obesity in the future. In consequence, this review focuses on the mechanisms of protein acetylation controlled obesity, to provide theoretical basis for controlling obesity and curing obesity-related diseases, which is a significance for regulating obesity in the future. This review will focus on the role of protein acetylation in controlling obesity.

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Acknowledgements

We would like to acknowledge these funds for supporting with this article.

Funding

This study was financially supported by the Key Sci-tech innovation team of Shaanxi province (2017KCT-24), the Joint Funds of the National Natural Science Foundation of China (U1804106), the Natural Science Foundation of China (81860762), and the Fundamental Research Funds for the Central Universities (245201971).

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  1. Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China

    Yuexia Liu, Hong Yang, Xuanchen Liu, Huihui Gu, Yizhou Li & Chao Sun

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  2. Hong Yang
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Yuexia Liu finished writing the manuscript; Hong Yang and Xuanchen Liu Liu participated in modifying the article; and Huihui Gu and Yizhou Li participated in inquiring about relevant information of the review.

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Correspondence to Chao Sun.

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Liu, Y., Yang, H., Liu, X. et al. Protein acetylation: a novel modus of obesity regulation. J Mol Med 99, 1221–1235 (2021). https://doi.org/10.1007/s00109-021-02082-2

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