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HMGA2 and high-grade serous ovarian carcinoma

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Abstract

HMGA2, the High Mobility Group A2 gene, plays a very important role in fetal development and carcinogenesis. As an oncofetal gene, it is upregulated in tumors of both epithelial and mesenchymal tissue origin. Chromosomal translocations of HMGA2 are common in mesenchymal tumors, whereas the regulatory mechanisms of HMGA2 in malignant epithelial tumors are much more complex. As an architectural transcription factor, it is involved in multiple biological pathways by targeting different downstream genes in different cancers. HMGA2 is upregulated in both the early and late stages of high-grade serous ovarian carcinoma (HGSOC) and, according to The Cancer Genomic Atlas, is among a signature of genes overexpressed in ovarian cancer. Recent identification of miR-182 as a mediator of BRCA1 and HMGA2 deregulation in ovarian cancer cells may guide us toward a better understanding of the roles of HMGA2 in ovarian carcinogenesis. In this article, we will review recent developments and findings related to HMGA2, including its regulation, oncogenic properties, major functional pathways associated with the tumorigenesis of HGSOC, and its potential role as a biomarker for clinical application.

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Acknowledgments

This work is partially supported by awards from the Dixon Translation Research Fund and the Marsha Rivkin Ovarian Cancer Center Fund.

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No potential conflicts of interest were disclosed.

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Authors and Affiliations

  1. Department of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China

    Jingjing Wu

  2. Department of Pathology, School of Medicine, Northwestern University, Feinberg 7-334, 251 East Huron Street, Chicago, IL, 60611, USA

    Jian-Jun Wei

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  1. Jingjing Wu
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  2. Jian-Jun Wei
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Correspondence to Jian-Jun Wei.

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Wu, J., Wei, JJ. HMGA2 and high-grade serous ovarian carcinoma. J Mol Med 91, 1155–1165 (2013). https://doi.org/10.1007/s00109-013-1055-8

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  • DOI: https://doi.org/10.1007/s00109-013-1055-8

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