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Protein kinase CK2, an important regulator of the inflammatory response?

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Abstract

Casein kinase 2 (CK2) is a highly conserved serine–threonine kinase that uses both adenosine triphosphate and guanosine triphosphate as phosphate donors. This constitutively active and ubiquitously expressed enzyme is often present as a tetrameric holoenzyme complex of two catalytic subunits (α and/or α’) and two regulatory β subunits. The enzyme is known to phosphorylate more than 300 substrates and controls a wide range of processes, including the regulation of cell cycle, apoptosis, transformation, and circadian rhythm. Several lines of recent evidence also suggest a potentially important role for CK2 in the control of the inflammatory response. This review will give an overview of CK2 and its regulation and describe the evidence implicating its role in inflammation.

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Acknowledgements

We thank the British Heart Foundation and the Wellcome Trust for financial support and apologize to all those authors whose work could not be cited because of space limitations.

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  1. Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, UK

    Nishi N. Singh & Dipak P. Ramji

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Singh, N.N., Ramji, D.P. Protein kinase CK2, an important regulator of the inflammatory response?. J Mol Med 86, 887–897 (2008). https://doi.org/10.1007/s00109-008-0352-0

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