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Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction

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Abstract

Complement factor H (CFH) plays a critical role in the protection of host cells and tissues from damage by complement activation and has been suggested to protect against the progression of atherosclerosis. A polymorphism in the CFH gene, Y402H, known to be strongly associated with age-related macular degeneration, has been analyzed in relation to coronary artery disease (CAD) in several studies with conflicting results. We investigated the association of polymorphisms of the CFH gene in two large-scale studies on CAD and myocardial infarction (MI). The AtheroGene Study included a cohort of cases with CAD (n = 1,303) prospectively followed for a median period of 6.2 years, among whom198 experienced a cardiovascular event, and a group of 483 control subjects. The AtheroGene Study population was genotyped for the Y402H, I62V, and E936D polymorphisms. There was no significant difference in genotypic or allelic frequencies between CAD cases and controls. Among cases, no significant association was found with prospective cardiovascular outcome. Many inflammatory proteins, including the C-reactive protein, were measured, and none of the polymorphisms showed an association with these markers. The Etude Cas-Témoin de l’Infarctus du Myocarde (ECTIM) Study compared 1,034 patients with MI and 1,039 controls from France and United Kingdom. The ECTIM Study population was genotyped for the Y402H polymorphism. Genotype and allele frequencies were similar in cases and controls. These results do not support an involvement of common nonsynonymous polymorphisms of the CFH gene in predisposition to CAD and its complications.

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Abbreviations

ACS:

acute coronary syndrome

AMD:

age-related macular degeneration

CAD:

coronary artery disease

CFH:

complement factor H

CRP:

C-reactive protein

ECTIM:

Etude Cas-Témoin de l’Infarctus du Myocarde

LD:

linkage disequilibrium

MI:

myocardial infarction

MONICA:

MONItoring trends and determinants in CArdiovascular diseases

SAP:

stable angina pectoris

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Authors and Affiliations

  1. INSERM UMR S525, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l’Hôpital, Paris, 75013, France

    Viviane Nicaud, Carole Francomme, François Cambien & Laurence Tiret

  2. Université Pierre et Marie Curie-Paris6, UMR S 525, Paris, 75634, France

    Viviane Nicaud, Carole Francomme, François Cambien & Laurence Tiret

  3. INSERM U518, Faculté de Médecine, MONICA Toulouse, Toulouse, 31073, France

    Jean-Bernard Ruidavets

  4. INSERM U508, MONICA Lille, Service d’Epidémiologie et de Santé Publique, Institut Pasteur, Lille, 59019, France

    Gérald Luc

  5. EA1801-Laboratoire d’Epidémiologie et de Santé Publique, Faculté de médecine, MONICA Strasbourg, Strasbourg, 67085, France

    Dominique Arveiler

  6. Department of Epidemiology and Public Health, Queen’s University of Belfast, Belfast, UK

    Frank Kee & Alun Evans

  7. The MONICA Project, Glasgow Royal Infirmary, Scotland, UK

    Caroline Morrison

  8. Department of Medicine II, Johannes Gutenberg–University Mainz, Mainz, Germany

    Stefan Blankenberg

Authors
  1. Viviane Nicaud
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  2. Carole Francomme
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  3. Jean-Bernard Ruidavets
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  4. Gérald Luc
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  5. Dominique Arveiler
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  6. Frank Kee
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  7. Alun Evans
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  8. Caroline Morrison
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  9. Stefan Blankenberg
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  10. François Cambien
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  11. Laurence Tiret
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Corresponding author

Correspondence to Laurence Tiret.

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Nicaud, V., Francomme, C., Ruidavets, JB. et al. Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction. J Mol Med 85, 771–775 (2007). https://doi.org/10.1007/s00109-007-0185-2

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  • DOI: https://doi.org/10.1007/s00109-007-0185-2

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