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Wundheilung und postoperative Behandlung nach Nasennebenhöhlenoperationen

Wound healing after endoscopic sinus surgery and postoperative management

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Zusammenfassung

Kenntnisse zur physiologischen Wundheilung der endonasalen Schleimhaut nach operativen Eingriffen helfen in vielen Fällen, offensichtliche oder verborgene Probleme der Ausheilung nach Nasennebenhöhleneingriffen nachzuvollziehen und anzugehen. In der vorliegenden Übersicht werden die Grundsätze der regelhaften Wundheilung dargestellt und daraus sich ableitende, häufige klinische Probleme erläutert. Auf der Grundlage der besonderen Anatomie und Physiologie werden die Ergebnisse der Erforschung regelhafter und gestörter Wundheilungsvorgänge der respiratorischen Schleimhaut dargestellt und mögliche Konsequenzen für einen veränderten Therapiestandard diskutiert.

Abstract

Understanding the physiological concepts of wound healing after rhinologic procedures facilitates detection and management of more or less obvious problems of wound healing. In this review, the physiologic processes involved in wound healing are explained, and typical clinical constellations are presented. Based on challenges of anatomy and physiology, recent findings are summarized, and possible conclusions for managing the postoperative mucosa are drawn.

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Literatur

  1. Agren MS, Jorgensen LN, Andersen M et al (1998) Matrix metalloproteinase 9 level predicts optimal collagen deposition during early wound repair in humans. Br J Surg 85:68–71. doi:10.1046/j.1365-2168.1998.00556.x

  2. Antisdel JL, Janney CG, Long JP et al (2008) Hemostatic agent microporous polysaccharide hemospheres (MPH) does not affect healing or intact sinus mucosa. Laryngoscope 118:1265–1269. doi:10.1097/MLG.0b013e31816c7bc9

    Google Scholar 

  3. Athanasiadis T, Beule AG, Robinson BH et al (2008) Effects of a novel chitosan gel on mucosal wound healing following endoscopic sinus surgery in a sheep model of chronic rhinosinusitis. Laryngoscope 118:1088–1094. doi:10.1097/MLG.0b013e31816ba576

    Google Scholar 

  4. Behrbohm H, Sydow K (1991) Nuklearmedizinische Untersuchungen zum Reparationsverhalten der Kieferhohlenschleimhaut nach FES. HNO 39:173–176

    PubMed  CAS  Google Scholar 

  5. Bernstein JM, Lebowitz RA, Jacobs JB (1998) Initial report on postoperative healing after endoscopic sinus surgery with the microdebrider. Otolaryngol Head Neck Surg 118:800–803. doi:10.1016/S0194-5998(98)70272-4

    Google Scholar 

  6. Beule A, Athanasiadis T, Athanasiadis E et al (2009) Efficacy of sinonasal irrigation after Lothrop procedure. Am J Rhinol 23(1):85–90

    Article  Google Scholar 

  7. Beule A, Steinmeier E, Kaftan H et al (2009) Effects of a dexamethasone-releasing stent on osteoneogenesis in a rabbit model. Am J Rhinol (in press)

  8. Beule AG, Scharf C, Biebler KE et al (2008) Effects of topically applied dexamethasone on mucosal wound healing using a drug-releasing stent. Laryngoscope 118:2073–2077. doi:10.1097/MLG.0b013e3181820896

    Google Scholar 

  9. Beule AG, Weber RK, Kaftan H et al (2004) Übersicht: Art und Wirkung geläufiger Nasentamponaden. Laryngorhinootologie 83:534–551. doi:10.1055/s-2004-825695

    Google Scholar 

  10. Bugten V, Nordgard S, Steinsvag S (2008) Long-term effects of postoperative measures after sinus surgery. Eur Arch Otorhinolaryngol 265:531–537. doi:10.1007/s00405-007-0501-z

    Google Scholar 

  11. Cannady SB, Batra PS, Citardi MJ et al (2005) Comparison of delivery of topical medications to the paranasal sinuses via „vertex-to-floor“ position and atomizer spray after FESS. Otolaryngol Head Neck Surg 133:735–740. doi:10.1016/j.otohns.2005.07.039

    Google Scholar 

  12. Cho SH, Shin KS, Lee YS et al (2008) Impact of chronic rhinosinusitis and endoscopic sinus surgery on bone remodeling of the paranasal sinuses. Am J Rhinol 22:537–541. doi:10.2500/ajr.2008.22.3222

    Google Scholar 

  13. DelGaudio JM, Wise SK (2006) Topical steroid drops for the treatment of sinus ostia stenosis in the postoperative period. Am J Rhinol 20:563–567. doi:10.2500/ajr.2006.20.2904

    Google Scholar 

  14. Desrosiers MY, Kilty SJ (2008) Treatment alternatives for chronic rhinosinusitis persisting after ESS: what to do when antibiotics, steroids and surgery fail. Rhinology 46:3–14

    PubMed  Google Scholar 

  15. Erickson VR, Antunes M, Chen B et al (2008) The effects of retinoic acid on ciliary function of regenerated sinus mucosa. Am J Rhinol 22:334–336. doi:10.2500/ajr.2008.22.3176

    Google Scholar 

  16. Forsgren K, Jung YG, Stierna P et al (1999) Regeneration of nerve fibres in the maxillary mucosa after experimental surgery. An immunocytochemical double-labelling study in the rabbit. Acta Otolaryngol 119:486–491. doi:10.1080/00016489950181044

    Google Scholar 

  17. Forsgren K, Stierna P, Kumlien J et al (1993) Regeneration of maxillary sinus mucosa following surgical removal. Experimental study in rabbits. Ann Otol Rhinol Laryngol 102:459–466

    PubMed  CAS  Google Scholar 

  18. Franz D, Roeder N, Alberty J (2005) DRG Evaluationsprojekt Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie: Abbildungsqualität stationärer Therapien der Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals- Chirurgie und Anpassungsbedarf des G-DRG-Systems. Schüling, Münster

  19. Frenkiel S, Desrosiers MY, Nachtigal D (2002) Use of hylan B gel as a wound dressing after endoscopic sinus surgery. J Otolaryngol 31(Suppl 1):S41–S44. doi:10.2310/7070.2002.21296

    Google Scholar 

  20. Goslen J (1988) Wound healing for the dermatologic surgeon. J Dermatol Surg Oncol 14:959–972

    PubMed  CAS  Google Scholar 

  21. Grobler A, Weitzel EK, Beule A et al (2008) Pre- and postoperative sinus penetration of nasal irrigation. Laryngoscope 118:2078–2081. doi:10.1097/MLG.0b013e31818208c1

    Google Scholar 

  22. Hosemann W, Dunker I, Göde U et al (1991) Experimentelle Untersuchungen zur Wundheilung in den Nasennebenhöhlen. III. Endoskopie und Histologie des Operationsgebietes nach einer endonasalen Siebbeinausräumung. HNO 39:111–115

    PubMed  CAS  Google Scholar 

  23. Hosemann W, Göde U, Länger F et al (1991) Experimentelle Untersuchungen zur Wundheilung in den Nasennebenhöhlen. II. Spontaner Wundschluß und medikamentöse Effekte im standardisierten Wundmodell. HNO 39:48–54

    PubMed  CAS  Google Scholar 

  24. Hosemann W, Wigand ME, Göde U et al (1991) Normal wound healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol 248:390–394. doi:10.1007/BF01463560

    Google Scholar 

  25. Huang HM, Cheng JJ, Liu CM et al (2006) Mucosal healing and mucociliary transport change after endoscopic sinus surgery in children with chronic maxillary sinusitis. Int J Pediatr Otorhinolaryngol 70:1361–1367. doi:10.1016/j.ijporl.2006.01.016

    Google Scholar 

  26. Inanli S, Tutkun A, Batman C et al (2000) The effect of endoscopic sinus surgery on mucociliary activity and healing of maxillary sinus mucosa. Rhinology 38:120–123

    PubMed  CAS  Google Scholar 

  27. Jacob A, Faddis BT, Chole RA (2002) MeroGel hyaluronic acid sinonasal implants: osteogenic implications. Laryngoscope 112:37–42. doi:10.1097/00005537-200201000-00007

    Google Scholar 

  28. Jones J (2005) Winter’s concept of moist wound healing: a review of the evidence and impact on clinical practice. J Wound Care 14:273–276

    PubMed  CAS  Google Scholar 

  29. Jorissen M (2004) Postoperative care following endoscopic sinus surgery. Rhinology 42:114–120

    PubMed  Google Scholar 

  30. Lee JY, Byun JY (2008) Relationship between the frequency of postoperative debridement and patient discomfort, healing period, surgical outcomes and compliance after endoscopic sinus surgery. Laryngoscope 118:1868–1872. doi:10.1097/MLG.0b013e31817f93d3

    Google Scholar 

  31. Liang KL, Su MC, Tseng HC et al (2008) Impact of pulsatile nasal irrigation on the prognosis of functional endoscopic sinus surgery. J Otolaryngol Head Neck Surg 37:148–153

    PubMed  Google Scholar 

  32. Lindeboom JA, Mathura KR, Aartman IH et al (2007) Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Implants Res 18:133–139. doi:10.1111/j.1600-0501.2006.01288.x

  33. Mauro T (2005) Natural course of wound repair versus impaired healing in chronic cutaneous ulcers. In: Shai A, Maibach H (eds) Wound healing and ulcers of the skin. Diagnosis and therapy – the practical approach. Springer, Berlin Heidelberg New York, pp 7–17

  34. McIntosh D, Cowin A, Adams D et al (2002) The effect of a dissolvable hyaluronic acid-based pack on the healing of the nasal mucosa of sheep. Am J Rhinol 16:85–90

    PubMed  Google Scholar 

  35. Park SW, Koo BS, Park YH et al (2006) Effect of topical mitomycin C for antrostomy in rabbit with sinusitis. Eur Arch Otorhinolaryngol 263:917–923. doi:10.1007/s00405-006-0083-1

    Google Scholar 

  36. Platt M, Cunnane M, Curtin H et al (2008) Anatomical changes of the ethmoid cavity after endoscopic sinus surgery. Laryngoscope 118:2240–2244. doi:10.1097/MLG.0b013e31818379cd

    Google Scholar 

  37. Pomerantz J, Dutton JM (2005) Platelet gel for endoscopic sinus surgery. Ann Otol Rhinol Laryngol 114:699–704

    PubMed  Google Scholar 

  38. Proctor M, Proctor K, Shu XZ et al (2006) Composition of hyaluronan affects wound healing in the rabbit maxillary sinus. Am J Rhinol 20:206–211

    PubMed  Google Scholar 

  39. Rajapaksa S, McIntosh D, Cowin A et al (2005) The effect of insulin-like growth factor 1 incorporated into a hyaluronic acid-based nasal pack on nasal mucosal healing in a healthy sheep model and a sheep model of chronic sinusitis. Am J Rhinol 19:251–256

    PubMed  Google Scholar 

  40. Rajapaksa SP, Ananda A, Cain TM et al (2004) Frontal ostium neo-osteogenesis and restenosis after modified endoscopic Lothrop procedure in an animal model. Clin Otolaryngol Allied Sci 29:386–388. doi:10.1111/j.1365-2273.2004.00824.x

  41. Sauer M, Lemmens W, Vauterin T et al (2007) Comparing the microdebrider and standard instruments in endoscopic sinus surgery: a double-blind randomised study. B-ENT 3:1–7

    Google Scholar 

  42. Schlosser RJ, Spotnitz WD, Rodeheaver G et al (2000) Effects of fibrin sealant-containing antibiotics in a rabbit model of chronic sinusitis. Am J Rhinol 14:233–240. doi:10.2500/105065800779954464

    Google Scholar 

  43. Selivanova O, Kuehnemund M, Mann WJ et al (2003) Comparison of conventional instruments and mechanical debriders for surgery of patients with chronic sinusitis. Am J Rhinol 17:197–202

    PubMed  Google Scholar 

  44. Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341:738–746. doi:10.1056/NEJM199909023411006

    Google Scholar 

  45. Snidvongs K, Chaowanapanja P, Aeumjaturapat S et al (2008) Does nasal irrigation enter paranasal sinuses in chronic rhinosinusitis? Am J Rhinol 22:483–486. doi:10.2500/ajr.2008.22.3221

    Google Scholar 

  46. Soldati D, Rahm F, Pasche P (1999) Mucosal wound healing after nasal surgery. A controlled clinical trial on the efficacy of hyaluronic acid containing cream. Drugs Exp Clin Res 25:253–261

    PubMed  CAS  Google Scholar 

  47. Staffieri A, Marino F, Staffieri C et al (2008) The effects of sulfurous-arsenical-ferruginous thermal water nasal irrigation in wound healing after functional endoscopic sinus surgery for chronic rhinosinusitis: a prospective randomized study. Am J Otolaryngol 29:223–229. doi:10.1016/j.amjoto.2007.07.002

    Google Scholar 

  48. Tan L, Hatzirodos N, Wormald PJ (2008) Effect of nerve growth factor and keratinocyte growth factor on wound healing of the sinus mucosa. Wound Repair Regen 16:108–116. doi:10.1111/j.1524-475X.2007.00323.x

    Google Scholar 

  49. Tran KN, Beule AG, Singal D et al (2007) Frontal ostium restenosis after the endoscopic modified Lothrop procedure. Laryngoscope 117:1457–1462. doi:10.1097/MLG.0b013e31806865be

    Google Scholar 

  50. Valentine R, Athanasiadis T, Thwin M et al (2008) A prospective controlled trial of pulsed nasal nebulizer in maximally dissected cadavers. Am J Rhinol 22:390–394. doi:10.2500/ajr.2008.22.3191

    Google Scholar 

  51. Van den Steen P, Dubois B, Nelissen I et al (2002) Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 37:375–536. doi:10.1080/10409230290771546

    Google Scholar 

  52. Vauterin T, Poorten VV, Jorissen M (2000) Cutting forceps in functional endoscopic sinus surgery. Acta Otorhinolaryngol Belg 54:29–37

    PubMed  CAS  Google Scholar 

  53. Vu T, Werb Z (1998) Gelatinase B: Structure, regulation and function in matrix metalloproteinases. Academic Press, San Diego

  54. Watelet JB, Bachert C, Claeys C et al (2004) Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis. Allergy 59:54–60. doi:10.1046/j.1398-9995.2003.00364.x

  55. Watelet JB, Bachert C, Gevaert P et al (2002) Wound healing of the nasal and paranasal mucosa: a review. Am J Rhinol 16:77–84

    PubMed  Google Scholar 

  56. Watelet JB, Claeys C, Van Cauwenberge P et al (2004) Predictive and monitoring value of matrix metalloproteinase-9 for healing quality after sinus surgery. Wound Repair Regen 12:412–418. doi:10.1111/j.1067-1927.2004.012411.x

  57. Watelet JB, Gevaert P, Bachert C et al (2002) Secretion of TGF-betal, TGF-beta2, EGF and PDGF into nasal fluid after sinus surgery. Eur Arch Otorhinolaryngol 259:234–238. doi:10.1007/s00405-002-0448-z

    Google Scholar 

  58. Weber R, Keerl R, Huppmann A et al (1996) Der Einfluss der Nachbehandlung auf die Wundheilung nach endonasaler Nasennebenhöhlenoperation. Laryngorhinootologie 75:208–214. doi:10.1055/s-2007-997564

    Google Scholar 

  59. Wright ED, Agrawal S (2007) Impact of perioperative systemic steroids on surgical outcomes in patients with chronic rhinosinusitis with polyposis: evaluation with the novel Perioperative Sinus Endoscopy (POSE) scoring system. Laryngoscope 117:1–28. doi:10.1097/MLG.0b013e31814842f8

    Google Scholar 

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Beule, A., Hosemann, W. Wundheilung und postoperative Behandlung nach Nasennebenhöhlenoperationen. HNO 57, 763–771 (2009). https://doi.org/10.1007/s00106-009-1938-8

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