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Wie sicher sind Nanopartikel?

How safe are nanoparticles?

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Zusammenfassung

Nanopartikuläre Substanzen finden in dermatologischen und kosmetischen Produkten zunehmend Anwendung, wobei die spezifischen Anforderungen an diese Nanosysteme dabei unterschiedlich ausfallen können. Als Bestandteil von Sonnenschutzmitteln sollen sich die Partikel beispielsweise hauptsächlich auf der Hautoberfläche und in den oberen Zelllagen des Stratum corneum anlagern, um die Haut optimal durch Reflexion und Absorption vor der UV-Strahlung der Sonne zu schützen. Als Trägersysteme für Wirkstoffe müssen die Partikel dagegen die Hautbarriere durchdringen, damit die Wirkstoffe die jeweiligen Zielstrukturen im Bereich der lebenden Zellen erreichen können. Im vorliegenden Beitrag werden die Perspektiven und Risiken der topischen Anwendung von Nanopartikeln diskutiert.

Abstract

Nanoparticles are experiencing an increasing application in dermatology and cosmetics. In both application areas, the requirements of nanoparticles are in most cases widely different. As a component of sunscreens, the nanoparticles are supposed to remain on the skin surface or in the upper most layers of the stratum corneum to protect the skin against UV-radiation of the sun. Whereas, on the other hand, when particulate substances are used as carrier systems for drugs, they have to cross the skin barrier to reach the target sites within the living tissue. We discuss the perspectives and risks of the topical application of nanoparticles.

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Danksagung

Wir danken der Stiftung für Hautphysiologie beim Stifterverband für die Deutsche Wissenschaft, Essen, für die finanzielle Unterstützung.

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

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Authors and Affiliations

  1. Center of Experimental and Applied Cutaneous Physiology (CCP), Klinik für Dermatologie, Venerologie und Allergologie, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland

    J. Lademann, M. Meinke, W. Sterry & A. Patzelt

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  1. J. Lademann
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  2. M. Meinke
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  3. W. Sterry
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  4. A. Patzelt
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Correspondence to J. Lademann.

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Lademann, J., Meinke, M., Sterry, W. et al. Wie sicher sind Nanopartikel?. Hautarzt 60, 305–309 (2009). https://doi.org/10.1007/s00105-008-1627-7

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