Zusammenfassung
Dieser Beitrag beschäftigt sich mit den grundlegenden Prinzipien der Photoprotektion durch herkömmliche Lichtschutzmittel mit chemischen und/oder physikalischen UV-Filtern sowie den Standardmethoden der Bestimmung des Lichtschutzfaktors (LSF). Die neuen behördlichen Direktiven und Empfehlungen der Europäischen Kommission hinsichtlich Photoprotektion werden vorgestellt und im Kontext derer anderer Regionen der Welt erörtert. Schlussendlich wird auch die Wirkung von Lichtschutzmitteln bei Nicht-Sonnenbrand-Effekten des Sonnenlichtes wie Immunsuppression und Hautkrebs diskutiert.
Abstract
This article describes the basic principles of photoprotection with classic sunscreens containing chemical and/or physical UV filters and standard methods of sun protection factor (SPF) determination. In addition, the new governmental regulations and recommendations of the European Commission for photoprotection are presented and compared to regulations in other regions of the world. Finally, the efficacy of sunscreens in sunlight-induced non-sunburn effects, such as immune suppression and carcinogenesis are discussed.
Literatur
COLIPA in Vitro Photoprotection Methods Task Force (2007) Method for the in vitro determination of UVA protection provided by sunscreen products. Guideline 2nd edn
(2006) Cosmetic, Toiletries and Fragrances Association of South Africa, The Cosmetics, Toiletries and Fragrances Association (CTFA-US), The European Cosmetic Toiletry and Perfumery Association (COLIPA), Japan Cosmetics Industry Association (JCIA), International Sun Protection Factor (SPF) Test Method
(2008) Measurement of UVA: UVB ratio according to the Boots star rating system (2008 revision). Boots UK Ltd, Nothingham (UK)
The Commission of the European Communities. Commission Recommendation of 22 September 2006 on the efficacy of sunscreen products and the claims made relating thereto. Official Journal of the European Union, L265/39, 26.9.2006
US Food and Drug Administration (2007) Sunscreen drug products for over-the-counter human use; proposed amendment of final monograph; proposed rule; 21CRF Parts 347 and 352. Fed Regist 72:49070–49122
Darlington S, Williams G, Neale R et al (2003) A randomized controlled trial to assess sunscreen application and beta carotene supplementation in the prevention of solar keratoses. Arch Dermatol 139:451–455
Fourtanier A, Moyal D, Maccario J et al (2005) Measurement of sunscreen immune protection factors in humans: a consensus paper. J Invest Dermatol 125:403–409
Gruber-Wackernagel A, Byrne SN, Wolf P (2009) Pathoghenic mechanisms of polymorphic light eruption. Front Biosci (in press)
Halliday GM, Norval M, Byrne SN et al (2008) The effects of sunlight on the skin. Drug discovery today: Disease mechanisms (doi:10.1016/j.ddmec.2008.04.005)
Kelly DA, Seed PT, Young AR et al (2003) A commercial sunscreen’s protection against ultraviolet radiation-induced immunosuppression is more than 50% lower than protection against sunburn in humans. J Invest Dermatol 120:65–71
Legat FJ, Wolf P (2006) Photodamage to the cutaneous sensory nerves: role in photoaging and carcinogenesis of the skin? Photochem Photobiol Sci 5:170–176
Maier H, Schauberger G, Brunnhofer K et al (2001) Change of ultraviolet absorbance of sunscreens by exposure to solar-simulated radiation. J Invest Dermatol 117:256–262
Maier H, Schauberger G, Martincigh BS et al (2005) Ultraviolet protective performance of photoprotective lipsticks: change of spectral transmittance because of ultraviolet exposure. Photodermatol Photoimmunol Photomed 21:84–92
Mastalier U, Kerl H, Wolf P (1998) Clinical, laboratory, phototest and phototherapy findings in polymorphic light eruptions: a retrospective study of 133 patients. Eur J Dermatol 8:554–559
Wang SQ, Stanfield JW, Osterwalder U (2008) In vitro assessments of UVA protection by popular sunscreens available in the United States. J Am Acad Dermatol 59:934–942
Wolf P (2003) Lichtschutzmittel: Wirkung gegen Hautkrebs und Lichtalterung. Hautarzt 54:839–844
Wolf P, Byrne SN, Gruber-Wackernagel A (2009) New insights into the mechanisms of polymorphic ligth eruption: resistance to ultraviolet radiation-induced immune suppression as an aetiological factor. Exp Dermatol 18:350–356
Wolf P, Donawho CK, Kripke ML (1993) Analysis of the protective effect of different sunscreens on ultraviolet radiation-induced local and systemic suppression of contact hypersensitivity and inflammatory responses in mice. J Invest Dermatol 100:254–259
Wolf P, Donawho CK, Kripke ML (1994) Effect of sunscreens on UV radiation-induced enhancement of melanoma growth in mice. J Natl Cancer Inst 86:99–105
Wolf P, Hoffmann C, Quehenberger F et al (2003) Immune protection factors of chemical sunscreens measured in the local contact hypersensitivity model in humans. J Invest Dermatol 121:1080–1087
Wolf P, Kripke ML (1998) Immunologic protection afforded by sunscreens beyond designated sun protection factors? J Invest Dermatol 110:184
Wolf P, Young A (2009) Photoprotection. In: Krutmann J, Hönigsmann H, Elmets CA (eds) Dermatological phototherapy and photodiagnostic methods, 2nd edn. Springer, Berlin Heidelberg New York Tokyo
Wolf P, Maier H, Mullegger RR et al. (2000) Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-alpha. J Invest Dermatol 114:149–156
Yarosh D, Klein J, O’Connor A et al (2001) Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group. Lancet 357:926-929
Yarosh DB, O’Connor A, Alas L et al. (1999) Photoprotection by topical DNA repair enzymes: molecular correlates of clinical studies. Photochem Photobiol 69:136–140
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Wolf, P. UV-Filter. Hautarzt 60, 285–293 (2009). https://doi.org/10.1007/s00105-008-1623-y
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DOI: https://doi.org/10.1007/s00105-008-1623-y