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Hypokomplementämisches Urtikaria-Vaskulitis-Syndrom

Erfolgreiche Therapie mit intravenösen Immunglobulinen

Hypocomplementemic urticarial vasculitis syndrome

Successful therapy with intravenous immunoglobulins

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Zusammenfassung

Autoimmunerkrankungen können klinisch unter dem Bild einer therapierefraktären chronischen Urtikaria (CU) auftreten. Der vorliegende Fall schildert den Verlauf bei einem Patienten mit hypokomplementämischem Urtikaria-Vaskulitis-Syndrom (HUVS) und den schnellen Behandlungserfolg mit hoch dosierten intravenösen Immunglobulinen (IVIG). Die Diagnose wurde klinisch gestellt und histologisch sowie laborchemisch gesichert. Bereits nach einem Zyklus mit IVIG (2 g/kg/Körpergewicht) waren alle Symptome deutlich rückläufig.

Abstract

Autoimmune diseases can initially present as chronic urticaria. We describe the course of a patient with hypocomplementemic urticarial vasculitis syndrome (HUVS) as well as his successful treatment with high-dose intravenous immunoglobulins (IVIG). HUVS was diagnosed clinically and confirmed by histology and laboratory studies. After only one cycle with IVIG (2 g/kg) all HUVS symptoms were significantly decreased.

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Authors and Affiliations

  1. Universitäts-Hautklinik Mainz, Langenbeckstraße 1, 55101, Mainz, Deutschland

    P. Staubach-Renz, E. von Stebut, W. Bräuninger, M. Maurer & K. Steinbrink

  2. Allergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Charité-Universitätsmedizin, Berlin, Deutschland

    M. Maurer

Authors
  1. P. Staubach-Renz
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  2. E. von Stebut
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  3. W. Bräuninger
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  4. M. Maurer
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  5. K. Steinbrink
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Correspondence to P. Staubach-Renz.

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Staubach-Renz, P., von Stebut, E., Bräuninger, W. et al. Hypokomplementämisches Urtikaria-Vaskulitis-Syndrom. Hautarzt 58, 693–697 (2007). https://doi.org/10.1007/s00105-007-1301-5

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  • DOI: https://doi.org/10.1007/s00105-007-1301-5

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