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Granuloma anulare

Granuloma annulare

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Zusammenfassung

Das Granuloma anulare ist eine benigne, meist selbstlimitierende Erkrankung unbekannter Ursache, gekennzeichnet durch dermale Papeln, die oft eine anuläre Konfiguration annehmen und die zu den granulomatösen entzündlichen Hauterkrankungen zählt, welche durch histomorphologisch nachweisbare Granulome gekennzeichnet sind. Neben lokalisierten Formen gibt es auch disseminierte Formen der Erkrankung. Die subjektiv oft weitgehend symptomlose Erkrankung muss nicht in jedem Falle therapiert werden. In der Therapie lokalisierter Formen des Granuloma anulare sind topische Glukokortikosteroide, Creme-PUVA-Therapie und Kryotherapie etabliert. Zur Behandlung disseminierter Formen haben sich Antimalariamittel, Antilepramittel, Retinoide und Fumarate sowie UVA-1- und PUVA-Therapie bewährt. Neuere Kasuistiken beschreiben den lokalen Einsatz von Calcineurinantagonisten und Imiquimod und den systemischen Einsatz von Biologicals zur erfolgreichen Therapie des Granuloma anulare.

Abstract

Granuloma annulare is a benign self-limiting disease of unknown origin, characterized by dermal papules tending to form annular shapes. It belongs to the granulomatous inflammatory skin diseases characterized by histomorphologically detectable granulomas. In addition to localized variants, generalized or disseminated variants also exist. The disease is often asymptomatic and does not require therapy in every case. Established therapies for localized forms of granuloma annulare are glucocorticosteroids, cream PUVA and cryosurgery. Antimalarials, antileprotics, retinoids, fumarates, UVA1 phototherapy and photochemotherapy are of value in disseminated cases. Recent case reports demonstrate the successful treatment of granuloma annulare with topical calcineurin antagonists or imiquimod and with the systemic administration of biologicals.

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Danksagung

Herrn Chefarzt Dr. med. C. Seidel, Institut für Pathologie und Tumordiagnostik am HUMAINE-Vogtland-Klinikum Plauen, danken wir für die Überlassung histologischer Schnittpräparate, Herrn Chefarzt Dr. med. G. Wagner, Hautklinik, Zentralkrankenhaus Reinkenheide der Seestadt Bremerhaven, für die Überlassung klinischer Aufnahmen.

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  1. Klinik für Hautkrankheiten und Allergologie, HUMAINE-Vogtland-Klinikum Plauen GmbH

    L. Kowalzick

  2. Klinik für Hautkrankheiten und Allergologie, HUMAINE-Vogtland-Klinikum Plauen GmbH, Postfach 100153, 08505, Plauen

    L. Kowalzick

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Correspondence to L. Kowalzick.

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Kowalzick, L. Granuloma anulare. Hautarzt 56, 1071–1083 (2005). https://doi.org/10.1007/s00105-005-1047-x

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