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Toleranzinduktion gegen Nickel

Vom Tiermodell zum Menschen

Tolerance induction towards nickel

From animal model to humans

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Zusammenfassung

Nickel ist das häufigste Kontaktallergen des Menschen. Dennoch waren bis vor kurzem viele Fragen insbesondere bezüglich der Toleranzmechanismen gegenüber Nickel nicht geklärt. Neben humanen Ex-vivo-, Interventions- und Beobachtungsstudien hat die Etablierung eines reproduzierbaren Mausmodells nun dazu beigetragen, diese Mechanismen besser zu analysieren. Erst das genauere Verständnis der Pathogenese der Nickelallergie und Toleranz gegenüber Nickel durch Untersuchungen im Tiermodell sowie in humanen Studien wird dazu beitragen, eine gezielte Prävention bzw. Therapie der Nickelallergie zu entwickeln. Wir beabsichtigen, mit dieser Arbeit einen Überblick über die im Tiermodell und im Menschen erhobenen Erkenntnisse zur Nickelallergie und vor allem zur oralen Toleranzinduktion gegenüber Nickel zu geben.

Abstract

Nickel is the most common contact allergen in humans. Until recently, many questions concerning tolerance mechanisms to nickel were unresolved. Besides human ex vivo, intervention and observation studies, the establishment of a reproducible mouse model has contributed to the analysis of these mechanisms. A more detailed understanding of the pathogenesis of nickel allergy and tolerance towards nickel by investigations in an animal model and in human studies is a prerequisite for developing specific prevention and therapy of nickel allergy. With this article, we provide a review of the investigations concerning nickel allergy and give perspectives towards oral tolerance induction to nickel in the animal model and in humans.

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  1. Institut für umweltmedizinische Forschung (IUF) an der Heinrich-Heine-Universität Düsseldorf gGmbH, Abteilung für Allergologie und Immunologie, Universitätshautklinik, Heinrich-Heine-Universität Düsseldorf

    S. Artik, E. Gleichmann & T. Ruzicka

  2. Universitätshautklinik der Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225 , Düsseldorf

    S. Artik

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Artik, S., Gleichmann, E. & Ruzicka, T. Toleranzinduktion gegen Nickel. Hautarzt 55, 1052–1059 (2004). https://doi.org/10.1007/s00105-004-0815-3

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