Zusammenfassung
Der Alterungsprozess wird von einer verstärkten oxidativen Schädigung begleitet. Alle zellulären Komponenten sind von diesen Oxidationsprozessen betroffen, u. a. auch Proteine. In der Zelle ist das Proteasom dafür verantwortlich, diese oxidierten Proteine selektiv abzubauen. Im Alterungsprozess ist diese Funktion zunehmend gestört: Es kommt somit zur Akkumulation oxidierter Proteine und zur Bildung von Lipofuszin, einem hochgradig vernetzten und modifizierten Proteinaggregat. Dieses akkumuliert in Zellen und ist in der Lage, das Proteasom zu hemmen. Im Zellkern kommt es zu weniger ausgeprägten Veränderungen des Proteasoms, da hier kein Lipofuszin akkumuliert.
Abstract
The ageing process is accompanied by enhanced oxidative damage. All cellular components including proteins are affected by oxidation. Within the cell, the proteasome is responsible for the degradation of these oxidised proteins. During the ageing process this function of the proteasome is increasingly diminished, therefore oxidised proteins accumulate. Furthermore lipofuscin, a highly cross-linked and modified protein aggregate, is formed. This aggregate accumulates within cells and is able to inhibit the proteasome. The nucleus of the cells is less affected by these changes due to the lack of intranuclear lipofuscin accumulation.
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Grune, T. Proteinoxidation in der Alterung von Hautfibroblasten. Hautarzt 54, 818–821 (2003). https://doi.org/10.1007/s00105-003-0580-8
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DOI: https://doi.org/10.1007/s00105-003-0580-8