Skip to main content
Log in

Choledocholithiasis

Diagnostische und therapeutische Strategien

Common bile duct stones

Diagnostic and therapeutic management

  • CME Weiterbildung - Zertifizierte Fortbildung
  • Published:
Der Chirurg Aims and scope Submit manuscript

Zusammenfassung

Die besten prädiktiven Parameter für das Vorliegen von Gallengangssteinen sind Cholangitis, Ikterus sowie der direkte sonographische Steinnachweis. Bei hochgradigem Verdacht auf das Vorliegen einer Choledocholithiasis ist die Durchführung einer ERC (endoskopische retrograde Cholangiographie) indiziert, da bei Bestätigung der Verdachtsdiagnose in gleicher Sitzung die interventionelle Steinextraktion durchgeführt werden kann. Ist mit mittlerer Wahrscheinlichkeit von Gallengangssteinen auszugehen, sollte im 1. Schritt die Endosonographie oder Magnetresonanzcholangiographie erfolgen. Bei Patienten mit simultaner Cholezysto-/Choledocholithiasis wird allgemein das präoperative therapeutisches Splitting empfohlen. Die zum Standard gewordene laparoskopische Cholezystektomie erfolgt zeitversetzt (>24 h bis <6 Wochen) zur ERC/EPT (endoskopischen Papillotomie), um mögliche periinterventionelle Komplikationen abzuwarten. Bei primär offenem Vorgehen zeigt sich die offene Choledochusrevision der ERC mit EPT überlegen und stellt aus diesem Grunde auch die erste Behandlungsoption dar. Nur in ausgewählten Zentren mit entsprechender laparoskopischer Expertise stellt die laparoskopische Choledochusrevision eine Alternative zum therapeutischen Splitting dar.

Abstract

The best predictors for the presence of common bile duct stones (CBDS) are cholangitis, jaundice, and direct visualization of stones with ultrasound. In the setting of high suspicion of choledocholithiasis, endoscopic retrograde cholangiography (ERC) is indicated because when CBDS are identified, it allows immediate therapy in the same sitting. If there is a moderate probability of choledocholithiasis, endosonography or magnetic resonance cholangiopancreatography are the first-line options. In patients with gallbladder stones and CBDS, preoperative ERC with or without endoscopic sphincterotomy (ES) is widely recommended as a standard approach. The interval between that and laparoscopic cholecystectomy (LC) should be at least 24 h (<6 weeks) to exclude possible complications due to the ERC/ES. In the setting of open cholecystectomy, open bile duct surgery is significantly superior to ERC with sphincterotomy in achieving common bile duct clearance and is the method of choice. Only in centres with advanced laparoscopic expertise is the laparoscopic removal of CBDS an equivalent treatment option.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6

Literatur

  1. Morgenstern L, Wong L, Berci G (1993) Twelve hundred open cholecystectomies before the laparoscopic era. A standard for comparison. Arch Surg 27: 400–403

    Google Scholar 

  2. Neoptolemos JP, Carr-Locke DL, Fossard DP (1987) Prospective randomized study of preoperative endoscopic sphincterotomy versus surgery alone for common bile duct stones. Br Med J 294: 470–474

    CAS  Google Scholar 

  3. Cwik G, Wallner G, Ciechanski A et al. (2003) Endoscopic sphincterotomy in 100 patients scheduled for laparoscopic cholecystectomy: ultrasound evaluation. Hepatogastroenterology 50: 1225–1228

    PubMed  Google Scholar 

  4. Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten und der der Deutschen Gesellschaft für Viszeralchirurgie Diagnostik und Therapie von Gallensteinen AWMF-Leitlinienregister Nr. 021/008, Entwicklungsstufe 3

  5. Abboud PA, Malet PF, Berlin JA et al. (1996) Predictors of common bile duct stones prior to cholecystectomy: a meta-analysis. Gastrointest Endosc 44: 450–455

    Article  PubMed  CAS  Google Scholar 

  6. Cohen S, Bacon BR, Berlin JA et al. (2002) NIH state-of-the-science statement on endoscopic retrograde cholangiopancreaticography (ERCP) for diagnosis and therapy. NIH Consensus State Sci Statements 19: 1–26

    Google Scholar 

  7. Moon JH, Cho YD, Cha SW (2005) The detection of bile duct stones in suspected biliary pancreatitis: comparison of MRCP, ERCP and intraductal US. Am J Gastroenterol 100: 1051–1057

    Article  PubMed  Google Scholar 

  8. Verma D, Kapedia A, Eisen GM et al. (2006) EUS vs. MRCP for detection of choledocholithiasis. Gastrointest Endosc 64: 248–254

    Article  PubMed  Google Scholar 

  9. Mirbagheri SA, Mohamadnejad M, Nasiri J et al. (2005) Prospective evaluation of endoscopic ultrasonography in the diagnosis of biliary microlithiasis in patients with normal transabdominal ultrasonography. J Gastrointest Surg 9: 961–964

    Article  PubMed  Google Scholar 

  10. Ney MV, Maluf-Filho F, Sakai P et al. (2005) Echo-endoscopy versus endoscopic retrograde cholangiography for the diagnosis of Choledocholithiasis: the influence of the size of the stone and diameter of the common bile duct. Arq Gastroenterol 42: 239–243

    Article  PubMed  Google Scholar 

  11. Tranter SE, Thompson MH (2003) A prospective single-blinded controlled study comparing laparoscopic ultrasound of the common bile duct with operative cholangiography. Surg Endosc 17: 216–219

    Article  PubMed  CAS  Google Scholar 

  12. Rosenthal RJ, Steigerwald SD, Imig R, Bockhorn H (1994) Role of intraoperative cholangiography during endoscopic cholecystectomy. Surg Laparosc Endosc 4: 171–174

    PubMed  CAS  Google Scholar 

  13. Griniatsos J, Karvounis E, Isla AM (2005) Limitations of fluoroscopic intraoperative cholangiography in cases suggestive of choledocholithiasis. J Laparoendosc Adv Surg Tech A 15: 312–317

    Article  PubMed  Google Scholar 

  14. Ludwig K, Köckerling F, Hohenberger W, Lorenz D (2001) Die chirurgische Therapie der Cholezysto-/ Choledocholithiasis. Ergebnisse einer deutschlandweiten Umfrage an 859 Kliniken mit 123.090 Cholezystektomien. Chirurg 72: 1171–1178

    Article  PubMed  CAS  Google Scholar 

  15. Hüttl TP, Hrdina C, Krämling HJ et al. (2001) Gallstone surgery in German university hospitals. Development, complications and changing strategies. Langenbecks Arch Surg 386: 410–417

    Article  PubMed  Google Scholar 

  16. Wright BE, Freeman ML, Cumming JK et al. (2002) Current management of common bile duct stones; is there a role for laparoscopic cholecystectomy and intraoperative endoscopic retrograde cholangiopancreatography as a single-stage procedure? Surgery 132: 729–737

    Article  PubMed  Google Scholar 

  17. Enochson L, Lindberg B, Swahn F, Arnelo U (2004) Intraoperative endoscopic retrograde cholangiopancreatography (ERCP) to remove common bile duct stones during routine laparoscopic cholecystectomy does not prolong hospitalization. Surg Endosc 18: 367–371

    Article  Google Scholar 

  18. Caddy GR, Kirby J, Kirk SJ et al. (2005) Natural history of asymptomatic bile duct stones at time of cholecystectomy. Ulster Med J 74: 108–112

    PubMed  CAS  Google Scholar 

  19. Weinberg BM, Shindy W, Lo S (2006) Endoscopic balloon sphincter dilation (sphincteroplasty versus sphincterotomy for common bile duct stones. Cochrane Database Syst Rev CD004890466

  20. Rhodes M, Sussman L, Cohen L, Lewis MP (1998) Randomized trial of laparoscopic exploration of common bile duct versus postoperative endoscopic retrograde cholangiography for common bile duct stones. Lancet 351: 159–161

    Article  PubMed  CAS  Google Scholar 

  21. Livingston EH, Rege RV (2005) Technical complications are rising as common duct exploration is becoming rare. J Am Coll Surg 201: 426–433

    Article  PubMed  Google Scholar 

  22. Kullmann E, Chu M, Svandik J, Borch K (1995) Trends in diagnosis, management and outcome of common bile duct stones: a population based study. Dig Surg 12: 92–97

    Google Scholar 

  23. Sheen-Chen SM, Chou FF (1990) Choledochotomy for biliary lithiasis: is routine T-tube drainage necessary? A prospective controlled trial. Acta Chir Scand 156: 387–390

    PubMed  CAS  Google Scholar 

  24. Tokumura H, Umezawa A, Cao H et al. (2002) Laparoscopic management of common bile duct stones: transcystic approach and choledochotomy. J Hepatobiliary Pancreat Surg 9: 206–212

    Article  PubMed  Google Scholar 

  25. Ebner S, Rechner J, Beller S et al. (2004) Laparoscopic management of common bile duct stones. Surg Endosc 18: 762–765

    Article  PubMed  CAS  Google Scholar 

  26. Martin DJ, Vernon DR, Toouli J (2006) Surgical versus endoscopic treatment of bile duct stones. Cochrane Database Syst Rev CD003327

  27. Clayton ESJ, Connor S, Alexakis N, Leandros E (2006) Meta-analysis of endoscopy and surgery versus surgery alone for common bile duct stones with the gallbladder in situ. Br J Surg 93: 1185–1191

    Article  PubMed  CAS  Google Scholar 

  28. Binmoeller KF, Sochendra N, Liguory C (1994) The common bile duct stone: time to leave it to the laparoscopic surgeon? Endosc 26: 315–319

    Article  CAS  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Förster.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Förster, S., Klar, E. Choledocholithiasis. Chirurg 79, 881–892 (2008). https://doi.org/10.1007/s00104-008-1588-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00104-008-1588-5

Schlüsselwörter

Keywords

Navigation