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Pyloruserhaltende Pankreaskopfresektion

Neuer Standard bei Tumoren

Pylorus-preserving pancreatic head resection

A new standard for tumors

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Zusammenfassung

Die pyloruserhaltende Pankreaskopfresektion nach Traverso-Longmire gilt zur operativen Behandlung von Pankreaskopftumoren als Standardeingriff. Sie ist in Bezug auf Mortalität, Morbidität und onkologische Radikalität als gleichwertig zur klassischen Pankreaskopfresektion nach Kausch-Whipple zu bewerten und zeichnet sich zudem durch kürzere Operationszeit und geringeren Blutverlust aus. Für das Langzeitüberleben ist jedoch nicht die Frage nach Erhalt bzw. Resektion des Magens entscheidend, sondern vielmehr die frühzeitige Diagnosestellung mit nachfolgender R0-Tumorresektion. Patienten profitieren dabei grundlegend von der Behandlung in einem auf Pankreaserkrankungen spezialisierten Zentrum.

Abstract

Traverso-Longmire pylorus-preserving pancreatic head resection is regarded as the standard surgical procedure for pancreatic head tumors. The mortality, morbidity, and oncological radicality are as low as with the classic Kausch-Whipple resection, with the additional advantage of shorter operating time and reduced blood loss. Important for long-term survival is, however, not the resection of the stomach but the early diagnosis with subsequent R0 tumor resection. Patients can benefit fundamentally from this procedure if it is carried out at a specialized center.

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Literatur

  1. Adler G, Seufferlein T, Bischoff SC et al. (2008) S3–guideline „exocrine pancreatic carcinoma“ 20071. Z Gastroenterol 46: 449–482

    Article  Google Scholar 

  2. Andersson R, Vagianos C, Williamson R (2004) Preoperative staging and evaluation of resectability in pancreatic ductal adenocarcinoma. HPB (Oxford) 6: 5–12

    Google Scholar 

  3. Birkmeyer JD, Siewers AE, Finlayson EV et al. (2002) Hospital volume and surgical mortality in the United States. N Engl J Med 346: 1128–1137

    Article  PubMed  Google Scholar 

  4. Birkmeyer JD, Sun Y, Wong SL, Stukel TA (2007) Hospital volume and late survival after cancer surgery. Ann Surg 245: 777–783

    Article  PubMed  Google Scholar 

  5. Cubilla AL, Fortner J, Fitzgerald PJ (1978) Lymph node involvement in carcinoma of the head of the pancreas area. Cancer 4: 880–887

    Article  Google Scholar 

  6. Diener MK, Heukaufer C, Schwarzer G et al. (2008) Pancreaticoduodenectomy (classic Whipple) versus pylorus-preserving pancreaticoduodenectomy (pp Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database of Systematic Reviews Issue 2. Art. No.: CD006053. DOI: 10.1002/14651858.CD006053.pub2

  7. Diener MK, Knaebel HP, Heukaufer C et al. (2007) A systematic review and meta-analysis of pylorus-preserving versus classical pancreaticoduodenectomy for surgical treatment of periampullary and pancreatic carcinoma. Ann Surg 245: 187–200

    Article  PubMed  Google Scholar 

  8. Fischer CP, Hong JC (2006) Method of pyloric reconstruction and impact upon delayed gastric emptying and hospital stay after pylorus-preserving pancreaticoduodenectomy. J Gastrointest Surg 10: 215–219

    Article  PubMed  Google Scholar 

  9. Garcea G, Dennison AR, Pattenden CJ et al. (2008) Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature. JOP 9: 99–132

    PubMed  Google Scholar 

  10. Han SS, Kim SW, Jang JY, Park YH (2007) A comparison of the long-term functional outcomes of standard pancreatoduodenectomy and pylorus-preserving pancreatoduodenectomy. Hepatogastroenterology 54: 1831–1835

    PubMed  Google Scholar 

  11. Hermanek P, Riedl S, Büchler MW (2007) Maligne Tumoren des Pankreas (Teil V). In: Neuhaus P, Wittekind C (Hrsg) Klassifikation maligner Tumoren des Gastrointestinaltrakts II. Springer Medizin Verlag, Heidelberg

  12. Karanicolas PJ, Davies E, Kunz R et al. (2007) The pylorus: take it or leave it? Systematic review and meta-analysis of pylorus-preserving versus standard whipple pancreaticoduodenectomy for pancreatic or periampullary cancer. Ann Surg Oncol 14: 1825–1834

    Article  PubMed  Google Scholar 

  13. Klöppel G, Lohse T, Bosslet K, Rückert K (1987) Ductal adenocarcinoma of the head of the pancreas: incidence of tumor involvement beyond the Whipple resection line. Histological and immunocytochemical analysis of 37 total pancreatectomy specimens. Pancreas 2: 170–175

    Article  PubMed  Google Scholar 

  14. Michalski CW, Kleeff J, Bachmann J et al. (2008) Second-look operation for unresectable pancreatic ductal adenocarcinoma at a high-volume center. Ann Surg Oncol 15: 186–192

    Article  PubMed  Google Scholar 

  15. Niedergethmann M, Shang E, Farag Soliman M et al. (2006) Early and enduring nutritional and functional results of pylorus preservation vs classic Whipple procedure for pancreatic cancer. Langenbecks Arch Surg 391: 195–202

    Article  PubMed  Google Scholar 

  16. Oettle H, Neuhaus P (2007) Adjuvant therapy in pancreatic cancer: a critical appraisal. Drugs 67: 2293–2310

    PubMed  CAS  Google Scholar 

  17. Ogata Y, Hishinuma S (2002) The impact of pylorus-preserving pancreatoduodenectomy on surgical treatment for cancer of the pancreatic head. J Hepatobiliary Pancreat Surg 9: 223–232

    Article  PubMed  Google Scholar 

  18. Ohtsuka T, Yamaguchi K, Ohuchida J et al. (2003) Comparison of quality of life after pylorus-preserving pancreatoduodenectomy and Whipple resection. Hepatogastroenterology 50: 846–850

    PubMed  Google Scholar 

  19. Paraskevas KI, Avgerinos C, Manes C et al. (2006) Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy: a review of the literature and critical reappraisal of the implicated pathomechanism. World J Gastroenterol 12: 5951–5958

    PubMed  Google Scholar 

  20. Pastorino G, Ermili F, Zappatore F et al. (1995) Multiparametric evaluation of functional outcome after pylorus-preserving duodenopancreatectomy. Hepatogastroenterology 42: 62–67

    PubMed  CAS  Google Scholar 

  21. Reddy SK, Tyler DS, Pappas TN, Clary BM (2007) Extended resection for pancreatic adenocarcinoma. Oncologist 12: 654–663

    Article  PubMed  Google Scholar 

  22. Riediger H, Makowiec F, Fischer E et al. (2006) Postoperative morbidity and long-term survival after pancreaticoduodenectomy with superior mesenterico-portal vein resection. J Gastrointest Surg 10: 1106–1115

    Article  PubMed  Google Scholar 

  23. Schnelldorfer T, Ware AL, Sarr MG et al. (2008) Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible? Ann Surg 247: 456–462

    Article  PubMed  Google Scholar 

  24. Schniewind B, Bestmann B, Henne-Bruns D et al. (2006) Quality of life after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head. Br J Surg 93: 1099–1107

    Article  PubMed  CAS  Google Scholar 

  25. Shrikhande SV, Qureshi SS, Rajneesh N, Shukla PJ (2005) Pancreatic anastomoses after pancreaticoduodenectomy: do we need further studies? World J Surg 29: 1642–1649

    Article  PubMed  Google Scholar 

  26. Storniolo AM, Enas NH, Brown CA et al. (1999) An investigational new drug treatment program for patients with gemcitabine: results for over 3000 patients with pancreatic carcinoma. Cancer 85: 1261–1268

    Article  PubMed  CAS  Google Scholar 

  27. Traverso LW, Longmire WP (1978) Preservation of the pylorus in pancreaticoduodenectomy. Surg Gynecol Obstet 146: 959–962

    PubMed  CAS  Google Scholar 

  28. Vanbeckevoort D (2007) Solid pancreatic masses: benign or malignant. JBR-BTR 90: 487–489

    Google Scholar 

  29. van Heek NT, Kuhlmann KF, Scholten RJ et al. (2005) Hospital volume and mortality after pancreatic resection: a systematic review and an evaluation of intervention in the Netherlands. Ann Surg 242: 781–788

    Article  Google Scholar 

  30. Watson K (1944) Carcinoma of ampulla of Vater. Successful radical resection. Br J Surg 31: 368–373

    Article  Google Scholar 

  31. Wenger FA, Jacobi CA, Haubold K et al. (1999) Gastrointestinal quality of life after duodenopancreatectomy in pancreatic carcinoma. Preliminary results of a prospective randomized study: pancreatoduodenectomy or pylorus-preserving pancreatoduodenectomy. Chirurg 70: 1454–1459

    Article  PubMed  CAS  Google Scholar 

  32. White R, Winston C, Gonen M et al. (2008) Current utility of staging laparoscopy for pancreatic and peripancreatic neoplasms. J Am Coll Surg 206: 445–450

    Article  PubMed  Google Scholar 

  33. Winter JM, Cameron JL, Campbell KA et al. (2006) 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience. J Gastrointest Surg 10: 1199–1210

    Article  PubMed  Google Scholar 

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Glanemann, M., Bahra, M. & Neuhaus, P. Pyloruserhaltende Pankreaskopfresektion. Chirurg 79, 1107–1114 (2008). https://doi.org/10.1007/s00104-008-1571-1

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  • DOI: https://doi.org/10.1007/s00104-008-1571-1

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