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Fetale Wundheilung

Aktueller Stand und neue Perspektiven

Fetal wound healing: current status and new perspectives

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Zusammenfassung

Das Merkmal der fetalen Wundheilung ist die narbenlose Heilung einer Wunde im frühen Gestationsalter. In den letzten 20 Jahren galt das Interesse der Forscher aus den verschiedensten Fachrichtungen den molekularen Regulationsmechanismen, die dem Phänomen der narbenlosen Wundheilung zugrunde liegen. Mit besserem Einblick in die zeitlich genau abgestimmten Abbau- und Synthesereaktionen können zukünftig wichtige Therapieoptionen zur Prävention und Reduktion der Narbenbildung nach chirurgischen Eingriffen und Traumen entwickelt werden. Ziel dieser Arbeit ist es, einen Überblick über die bedeutendsten Arbeiten der letzten 2 Jahrzehnte auf dem Gebiet der fetalen Wundheilung zu geben. Es soll auch auf die—aus dem fetalen Wundheilungsmodell entwickelten—Behandlungsansätze zur Modulation der adulten Narbenbildung eingegangen werden. Die bisher experimentell erzielten Ergebnisse unter Verwendung dieser neuen Therapieoptionen sind äußerst viel versprechend und richtungsweisend und stellen eine enorme Chance für die Chirurgie der Zukunft dar.

Abstract

The characteristic of fetal wound healing is scarless wound repair in early gestation. During the last two decades, intensive research efforts have focused on unraveling the molecular regulations underlying the phenomenon of scarless wound healing. Better understanding of synthesis and degradation will enable us to develop important therapeutic options for the prevention and reduction of scarring. The aim of this article is to present an overview, discuss the most important research works of the last two decades on the field of fetal wound healing, and report current therapeutic developments for the modulation of adult wound repair. Recent experimental results using these new therapeutic approaches are very promising and present great possibilities and chances for future surgery.

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Danksagung

Die Autoren danken allen Mitarbeitern der Arbeitsgruppe für „Intrauterine Chirurgie“ am Klinikum rechts der Isar, München (R. Bergmeyr, P. Boettcher, E. Brendel, T. Brill, W. Erhardt, R. Hertel, S. Klotz, M. Leucz, B. Matzen, V. Pohlheimer, A. Raith und R. Sader) für die Durchführung aktueller und zukünftiger Projekte und für die kritische Diskussion dieses Artikels. Wir danken auch unseren Industriepartnern (Auto Suture Germany GmbH, Baxter Germany—Immuno GmbH, Ethicon GmbH, Karl Storz Endoskope GmbH & Co., Ossacur AG, W. L. Gore & Associates GmbH) für ihre Hilfe, diese Projekte überhaupt möglich werden zu lassen.

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Authors and Affiliations

  1. Abteilung für Plastische & Wiederherstellungschirurgie, Klinikum rechts der Isar, Technische Universität München

    E. A. Huhn, D. Müller, L. Kovacs, E. Biemer &  N. A. Papadopulos

  2. Arbeitsgruppe für Experimentelle Chirurgie des Instituts für Experimentelle Onkologie & Therapieforschung, Klinikum rechts der Isar, Technische Universität München

    C. Jannowitz, H. Boos & J. Henke

  3. Abteilung für Kieferorthopädie, Aristoteles Universität Thessaloniki, Thessaloniki, Griechenland

    M. A. Papadopulos

  4. Abteilung für Rekonstruktionschirurgie Sektion Maxillofaziale Chirurgie, Kantonspital, Universität Basel, Basel, Schweiz

    H. F. Zeilhofer

  5. Abteilung für Plastische & Wiederherstellungschirurgie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 , München

    N. A. Papadopulos

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  1. E. A. Huhn
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  2. C. Jannowitz
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  10. N. A. Papadopulos
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Correspondence to N. A. Papadopulos.

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Huhn, E.A., Jannowitz, C., Boos, H. et al. Fetale Wundheilung. Chirurg 75, 498–507 (2004). https://doi.org/10.1007/s00104-004-0878-9

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