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Inhalationsallergien am Arbeitsplatz

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Workplace-related respiratory allergies

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Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Aims and scope

Zusammenfassung

Nicht selten können Inhalationsallergene am Arbeitsplatz berufsbedingte Atemwegserkrankungen verursachen. Die auslösenden Stoffe sind jedoch sehr unterschiedlich. Auch sind die jeweils zugrunde liegenden Pathomechanismen noch nicht in jedem Fall eindeutig geklärt. Während einige berufsbedingte Allergene, wie zum Beispiel die Allergene aus Naturlatex und Weizenmehl, systematisch erforscht wurden, sind die atemwegssensibilisierenden Wirkungen vieler anderer Arbeitsstoffe zum Teil nur in Einzelfällen dokumentiert. In der vorliegenden Übersichtsarbeit werden Inhalationsallergene am Arbeitsplatz gemäß ihrer Herkunft in pflanzliche, tierische, mikrobielle und chemische Stoffe unterschieden und jeweils getrennt nach ihrem Vorkommen in den verschiedenen Berufsfeldern und Anwendungsgebieten dargestellt. Neuere Aspekte in der Diagnostik berufsbedingter allergischer Atemwegserkrankungen werden ebenso aufgezeigt wie gesetzliche Regelungen zur Prävention von Atemwegssensibilisierungen.

Abstract

It is common that the inhalation of occupational allergens induces occupational airway diseases, but the inducers are diverse and complex, and the pathomechanism of the disease is not clear in every case. Only few allergens have been studied in detail (e.g., wheat flour and natural rubber latex), and most of the occupational airway sensitizers have only been documented as case reports. This review describes occupational type I aeroallergens according to their source (plant, animal, microbial, and chemical) and workplace application area. New aspects on the diagnosis and legal preventive regulations for occupational allergic airway diseases are described.

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Literatur

  1. Deutsche Gesetzliche Unfallversicherung Berlin (DGUV) (Hrsg) (2010) Dokumentation des Berufskrankheiten-Geschehens in Deutschland, BK-DOK 2008. Plump OHG, Rheinbreitbach

  2. Kampen V van, Merget R, Baur X (2000) Occupational airway sensitizers: an overview on the respective literature. Am J Ind Med 38:164–218

    Article  PubMed  Google Scholar 

  3. Raulf-Heimsoth M, Sander I, Kespohl S et al (2011) Seltene und neue berufliche Inhalationsallergene. Allergologie 1:27–32

    Google Scholar 

  4. Technische Regeln für Gefahrstoffe (TRGS, sämtliche) http://www.baua.de/de/Themen-von-A-Z/Gefahrstoffe/TRGS/TRGS.html; hier TRGS 406 und TRGS 907

  5. Quirce S, Sastre J (2011) New causes of occupational asthma. Curr Opin Allergy Clin Immunol 11:80–85

    Article  PubMed  Google Scholar 

  6. Houba R, Doekes G, Heederik D (1998) Occupational respiratory allergy in bakery workers: a review of the literature. Am J Ind Med 34:529–546

    Article  PubMed  CAS  Google Scholar 

  7. Sander I, Flagge A, Merget R et al (2001) Identification of wheat flour allergens by means of 2-dimensional immunoblotting. J Allergy Clin Immunol 107:907–913

    Article  PubMed  CAS  Google Scholar 

  8. Sander I, Rozynek P, Rihs HP et al (2011) Multiple wheat flour allergens and cross-reactive carbohydrate determinants bind IgE in baker’s asthma. Allergy 66:1208–1215

    Article  PubMed  CAS  Google Scholar 

  9. Palosuo K (2003) Update on wheat hypersensitivity. Curr Opin Allergy Clin Immunol 3:205–209

    Article  PubMed  Google Scholar 

  10. Bossert J, Wahl R (2000) Amaranth – ein neues Bäckerallergen. Allergologie 23:448–454

    Google Scholar 

  11. Park HS, Nahm DH (1996) Buckwheat flour hypersensitivity: an occupational asthma in a noodle maker. Clin Exp Allergy 26:423–427

    Article  PubMed  CAS  Google Scholar 

  12. Cartier A (2010) The role of inhalant food allergens in occupational asthma. Curr Allergy Asthma Rep 10:349–356

    Article  PubMed  Google Scholar 

  13. Quirce S, Polo F, Figueredo E et al (2000) Occupational asthma caused by soybean flour in bakers – differences with soybean-induced epidemic asthma. Clin Exp Allergy 30:839–846

    Article  PubMed  CAS  Google Scholar 

  14. Kespohl S, Schlünssen V, Jacobsen G et al (2010) Impact of cross-reactive carbohydrate determinants on wood dust sensitization. Clin Exp Allergy 40:1099–1106

    Article  PubMed  CAS  Google Scholar 

  15. Pérez-Rios M, Ruano-Ravina A, Etminan M, Takouche B (2009) A meta-analysis on wood dust exposure and risk of asthma. Allergy 65:467–473

    Article  PubMed  Google Scholar 

  16. Kespohl S, Sander I, Merget R et al (2005) Identification of an obeche (Triplochiton scleroxylon) wood allergen as a class I Chitinase. Allergy 60:808–814

    Article  PubMed  CAS  Google Scholar 

  17. Basomba A, Burches E, Almodovar A, Rojas DH de (1991) Occupational rhinitis and asthma caused by inhalation of Balfourodendron riedelianum (Pau Marfim) wood dust. Allergy 46:316–318

    Article  PubMed  CAS  Google Scholar 

  18. Bush RK, Yunginger JW, Reed CE (1978) Asthma due to African zebrawood (Microberlinia) dust. Am Rev Respir Dis117:601–603

    Google Scholar 

  19. Herold DA, Wahl R, Maasch HJ et al (1991) Occupational wood-dust sensitivity from Euonymus europaeus (spindle tree) and investigation of cross reactivity between E.e. wood and Artemisia vulgaris pollen (mugwort). Allergy 46:186–190

    Article  PubMed  CAS  Google Scholar 

  20. Kersten S, Wahl PG von (1994) Allergische Atemwegserkrankungen in der holzverarbeitenden Industrie. Allergologie 17:55–60

    Google Scholar 

  21. Oertmann C, Bergmann KC (1993) Atemwegserkrankungen bei Arbeitern im Holzgewerbe – Beobachtungen an 55 Gutachten-Fällen. Allergologie 8:334–340

    Google Scholar 

  22. Fernández-Rivas M, Pérez-Carral C, Senent CJ (1997) Occupational asthma and rhinitis caused by ash (Fraxinus excelsior) wood dust. Allergy 52:196–199

    Article  PubMed  Google Scholar 

  23. Eire MA, Pineda F, Losada SV et al (2006) Occupational rhinitis and asthma due to cedroarana (Cedrelinga catenaeformis Ducke) wood dust allergy. J Investig Allergol Clin Immunol 16:385–387

    PubMed  CAS  Google Scholar 

  24. Alday E, Gómez M, Ojeda P et al (2005) IgE-mediated asthma associated with a unique allergen from Angelim pedra (Hymenolobium petraeum) wood. J Allergy Clin Immunol 115:634–636

    Article  PubMed  CAS  Google Scholar 

  25. Kespohl S, Merget R, Overlack A et al (2006) Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.). J Allergy Clin Immunol 118:522–524

    Article  PubMed  CAS  Google Scholar 

  26. Kespohl S, Kotschy-Lang N, Tomm JM et al (2011) Occupational IgE-mediated softwood allergy – characterization of the allergen cause. Int Arch Allergy Immunol 157:202–208

    Article  PubMed  Google Scholar 

  27. Gerth Wijk R van, Patiwael JA, Jong NW de et al (2011) Occupational rhinitis in bell pepper greenhouse workers: determinants of leaving work and the effects of subsequent allergen avoidance on health-related quality of life. Allergy 66:903–908

    Article  Google Scholar 

  28. Groenewoud GC, Jong NW de, Burdorf A et al (2002) Prevalence of occupational allergy to Chrysanthemum pollen in greenhouses in the Netherlands. Allergy 57:835–840

    Article  PubMed  CAS  Google Scholar 

  29. Schubert H, Prater E (1990) Pollinosis als Berufskrankheit bei Gärtnern. Dermatol Monatsschr 176:97–104

    PubMed  CAS  Google Scholar 

  30. Piirilä P, Keskinen H, Leino T et al (1994) Occupational asthma caused by decorative flowers: Review and case reports. Int Arch Occup Environ Health 66:131–136

    Article  PubMed  Google Scholar 

  31. Hermanides HK, Laheÿ-de Boer AM, Zuidmeer L et al (2006) Brassica oleracea pollen, a new source of occupational allergens. Allergy 61:498–502

    Article  PubMed  CAS  Google Scholar 

  32. Groenewoud GC, Jong NW de, Oorschot-van Nes AJ van et al (2002) Prevalence of occupational allergy to bell pepper pollen in greenhouses in the Netherlands. Clin Exp Allergy 32:434–440

    Article  PubMed  CAS  Google Scholar 

  33. Patiwael JA, Vullings LGJ, Jong NW de et al (2010) Occupational allergy in strawberry greenhouse workers. Int Arch Allergy Immunol 152:58–65

    Article  PubMed  CAS  Google Scholar 

  34. Oldenburg M, Bittner C, Baur X (2010) Arbeitsbedingte Allergien auf Maispollen. Arbeitsmed Sozialmed Umweltmed 45:343

    Google Scholar 

  35. Maniu CM, Faupel U, Siebenhaar G, Hunzelmann N (2010) Maize: a new occupational allergen in the pharmaceutical industry. Allergy 65:930–931

    Article  PubMed  Google Scholar 

  36. Sander I, Raulf-Heimsoth M, Wiemer K et al (2006) Sensitization due to gum arabic (Acacia senegal): the cause of occupational allergic asthma or crossreaction to carbohydrates? Int Arch Allergy Immunol 141:51–56

    Article  PubMed  CAS  Google Scholar 

  37. Osterman K, Zetterström O, Johansson SG (1982) Coffee worker’s allergy. Allergy 37:313–322

    Article  PubMed  CAS  Google Scholar 

  38. Weber RW (2010) Castor bean, Ricinus communic. Ann Allergy Asthma Immunol 104:A4

    Google Scholar 

  39. Pirson F, Detry B, Pilette C (2009) Occupational rhinoconjunctivitis and asthma caused by chicory and oral allergy syndrome associated with Bet v 1-related protein. J Investig Allergol Clin Immunol 19:306–310

    PubMed  CAS  Google Scholar 

  40. Walt A van der, Lopata AL, Nieuwenhuizen NE, Jeebhay MF (2010) Work-related allergy and asthma in spice mill workers – the impact of processing dried spices on IgE reactivity patterns. Int Arch Allergy Immunol 152:271–278

    Article  PubMed  Google Scholar 

  41. Raulf-Heimsoth M, Rozynek P, Sander I et al (2004) Naturlatexallergie: molekulare Grundlagen und Kreuzreaktivitäten. Allergo J 13:328–336

    Google Scholar 

  42. Raulf-Heimsoth M, Rihs HP, Rozynek P et al (2007) Quantitative analysis of immunoglobulin E reactivity profiles in patients allergic or sensitized to natural rubber latex (Hevea brasiliensis). Clin Exp Allergy 37:1657–1667

    Article  PubMed  CAS  Google Scholar 

  43. Jeal H, Jones M (2010) Allergy to rodents: an update. Clin Exp Allergy 40:1593–1601

    Article  PubMed  CAS  Google Scholar 

  44. Fernández-Caldas E, Iraola V, Carnés J (2007) Molecular and biochemical properties of storage mites (except Blomia species). Protein Pept Lett 14:954–959

    Article  PubMed  Google Scholar 

  45. Franz JT, Masuch G, Müsken H, Bergmann KC (1995) Untersuchungen zur Vorratsmilbenfauna von Bauernhöfen in Nordrhein-Westfalen: Ostwestfalen. Allergologie 18:25–30

    Google Scholar 

  46. Kroidl RF, Schwichtenberg U, Frank E (2007) Asthma bronchiale bei Allergie gegen Vorratsmilben. Untersuchungen zur Häufigkeit und zu klinischen und allergologischen Daten. Pneumologie 61:525–530

    Article  PubMed  CAS  Google Scholar 

  47. Blainey AD, Topping MD, Ollier S, Davies RJ (1989) Allergic respiratory disease in grain workers: the role of storage mites. J Allergy Clin Immunol 84:296–303

    Article  PubMed  CAS  Google Scholar 

  48. Müsken H (2004) Vorratsmilben: aktuelles Wissen und Karenzmöglichkeiten. Allergo J 13:452–459

    Google Scholar 

  49. Groenewoud GC, Graaf in ‚t Veld C de, vVan Oorschot-van Nes AJ et al (2002) Prevalence of sensitization to the predatory mite Amblyseius cucumeris as a new occupational allergen in horticulture. Allergy 57:614–619

    Article  PubMed  CAS  Google Scholar 

  50. Kim YK, Kim YY (2002) Spider-mite allergy and asthma in fruit growers. Curr Opin Allergy Clin Immunol 2:103–107

    Article  PubMed  Google Scholar 

  51. Mäkinen-Kiljunen S, Mussalo-Rauhamaa H, Petman L et al (2001) A baker’s occupational allergy to flour moth (Ephestia kuehniella). Allergy 56:696–700

    Article  PubMed  Google Scholar 

  52. Jeebhay MF, Robins TG, Lehrer SB, Lopata AL (2001) Occupational seafood allergy: a review. Occup Environ Med 58:553–562

    Article  PubMed  CAS  Google Scholar 

  53. Jeebhay MF, Cartier A (2010) Seafood workers and respiratory disease: an update. Curr Opin Allergy Clin Immunol 10:104–113

    Article  PubMed  Google Scholar 

  54. Nieuwenhuizen N, Lopata AL, Jeebhay MF et al (2006) Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis. J Allergy Clin Immunol 117:1098–1105

    Article  PubMed  CAS  Google Scholar 

  55. Barbuzza O, Guarneri F, Galtieri G et al (2009) Protein contact dermatitis and allergic asthma caused by Anisakis simplex. Contact Dermatitis 60:239–240

    Article  PubMed  Google Scholar 

  56. Liebers V, Baur X (1994) Chironomidae haemoglobin Chi t I – characterization of an important inhalant allergen. Clin Exp Allergy 24:100–108

    Article  PubMed  CAS  Google Scholar 

  57. Liebers V, Hornstein M, Baur X (1993) Humoral immune response to the insect allergen Chi t I in aquarists and fish food factory workers. Allergy 48:236–239

    Article  PubMed  CAS  Google Scholar 

  58. Grammer LC (2001) The role of low molecular weight agents in environmental asthma. In: Bush RK (Hrsg) Environmental asthma. Marcel Dekker, New York, Basel, 153:239–263

  59. Vooght V de, Hox V, Nemery B, Vanoirbeek JAJ (2010) Mechanisms of occupational asthma caused by low-molecular-weight chemicals. In: Sigsgaard T, Heederik D (Hrsg) Occupational asthma. Birkhäuser, Springer, Basel, S 141–162

  60. Wisnewski AV, Jones M (2010) Pro/Con debate: Is occupational asthma induced by isocyanates an immunoglobulin E-mediated disease? Clin Exp Allergy 40:1155–1162

    Article  PubMed  CAS  Google Scholar 

  61. Merget R, Caspari C, Dierkes-Globisch A et al (2001) Effectiveness of a medical surveillance program for the prevention of occupational asthma caused by platinum salts: a nested case-control study. J Allergy Clin Immunol 107:707–712

    Article  PubMed  CAS  Google Scholar 

  62. Bernstein IL, Merget R (2006). Metals. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI (Hrsg) Asthma in the workplace, 3. Aufl. Marcel Dekker Inc., New York, S 525–554

  63. Merget R, Sander I, Kampen V van et al (2010) Occupational immediate-type asthma and rhinitis due to rhodium salts. Am J Ind Med 53:42–46

    PubMed  Google Scholar 

  64. Raulf-Heimsoth M, Gabrio T, Lorenz W, Radon K (2010) Vorkommen und gesundheitliche sowie allergologische Relevanz von Schimmelpilzen aus der Sicht der Umwelt- und Arbeitsmedizin, der Innenraumhygiene und der Epidemiologie. Allergo J 19:464–476

    Google Scholar 

  65. Piipari R, Keskinen H (2005) Agents causing occupational asthma in Finland in 1986–2002: cow epithelium bypassed by moulds from moisture-damaged buildings. Clin Exp Allergy 35:1632–1637

    Article  PubMed  CAS  Google Scholar 

  66. Merget R, Sander I, Rozynek P et al (2008) Occupational immunoglobulin E-mediated asthma due to Penicillium camemberti in a dry-sausage packer. Respiration 76:109–111

    Article  PubMed  CAS  Google Scholar 

  67. Heffler E, Nebiolo F, Pizzimenti S et al (2009) Occupational asthma caused by Neurospora sitophila sensitization in a coffee dispenser service operator. Ann Allergy Asthma Immunol 102:168–169

    Article  PubMed  Google Scholar 

  68. Green BJ, Beezhold DH (2011) Industrial fungal enzymes: an occupational allergen perspective. J Allergy (Cairo) 2011:682574

  69. Loureiro G, Tavares B, Pereira C et al (2009) Occupational allergy to fungal lipase in the pharmaceutical industry. J Investig Allergol Clin Immunol 19:242–244

    PubMed  CAS  Google Scholar 

  70. Kampen V van, Merget R, Raulf-Heimsoth M (2012) Aktueller Stand der in vivo- und in vitro-Diagnostik für berufsbedingte Soforttypallergien. Allergologie 35(2) (im Druck)

  71. Raulf-Heimsoth M (2010) Berufliche Typ-I-Allergien – in-vitro-Diagnostik: Was gibt es Neues? Haut 2:60–64

    Google Scholar 

  72. Renz H, Biedermann T, Bufe A et al (2010) In-vitro-Allergiediagnostik. Allergo J 19:110–128

    Google Scholar 

  73. Raulf-Heimsoth M, Rihs HP (2011) Latexallergene: Sensibilisierungsquellen und Einzelallergenprofile erkennen. Allergo J 20:241–243

    Google Scholar 

  74. Quirce S, Lemière C, Blay F de et al (2009) Noninvasive methods for assessment of airway inflammation in occupational settings. Allergy 65:445–458

    Article  PubMed  Google Scholar 

  75. Baur X, Gäßler A, Kampen V van et al (2003) Leitlinie Arbeitsmedizin der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. (DGAUM) „Prävention arbeitsbedingter obstruktiver Atemwegserkrankungen“. http://www.dgaum.de

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Raulf-Heimsoth, M., van Kampen, V., Kespohl, S. et al. Inhalationsallergien am Arbeitsplatz. Bundesgesundheitsbl. 55, 363–372 (2012). https://doi.org/10.1007/s00103-011-1432-9

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