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Aktuelle Entwicklungen in der Xenonforschung

Stellenwert für die Anästhesie und Intensivmedizin

Current developments in xenon research

Importance for anesthesia and intensive care medicine

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Zusammenfassung

Das Edelgas Xenon kommt in der Summe seiner Eigenschaften den Vorstellungen von einem idealen Anästhetikum sehr nahe. Es vereint optimale anästhetische Eigenschaften mit einem hohen Maß an hämodynamischer Stabilität. Daneben ermöglicht Xenon eine exzellent steuerbare und sichere Anästhesie. Lediglich der molekulare Wirkmechanismus im Gehirn ist nach wie vor nicht endgültig geklärt. Experimentell konnte gezeigt werden, dass Xenon, anscheinend ohne relevante Nebenwirkungen, organprotektive Eigenschaften an Herz, Gehirn und Nieren aufweist. Da der Einsatz von Xenon in der täglichen Routine aufgrund hoher Kosten und begrenzter Ressourcen weiterhin limitiert sein wird, ist es die Aufgabe zukünftiger Studien, seinen Stellenwert bei spezifischen Indikationen in Anästhesie und Intensivmedizin aufzuzeigen.

Abstract

The noble gas xenon exerts favorable anesthetic properties along with remarkable hemodynamic stability in healthy patients undergoing elective surgery. It represents the nearly ideal anesthetic and provides safe and well controllable anesthesia although the exact mechanism by which xenon produces anesthesia remains to be elucidated. In addition xenon offers organ protective properties for vital organs including the brain, heart and kidneys which seem to be synergistic when used in combination with therapeutic hypothermia. As the high cost of xenon will probably preclude its wider use as a routine anesthetic, data from extensive tests in large numbers of high risk patients is needed to confirm its possible superiority in this setting.

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Authors and Affiliations

  1. Klinik für Anästhesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland

    A. Brücken, M. Coburn, S. Rex & R. Rossaint

  2. Klinik für operative Intensivmedizin Erwachsene, Universitätsklinikum der RWTH Aachen, Aachen, Deutschland

    M. Fries

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  1. A. Brücken
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  2. M. Coburn
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  3. S. Rex
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  4. R. Rossaint
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Correspondence to A. Brücken.

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Brücken, A., Coburn, M., Rex, S. et al. Aktuelle Entwicklungen in der Xenonforschung. Anaesthesist 59, 883–895 (2010). https://doi.org/10.1007/s00101-010-1787-6

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