Skip to main content

Advertisement

Log in

Reconstruction of Large Diaphyseal Defects of the Femur and the Tibia with Autologous Bone

  • Focus on Soft Tissue and Bone Reconstruction
  • Published:
European Journal of Trauma and Emergency Surgery Aims and scope Submit manuscript

Abstract

Post-traumatic segmental bone defects of the femur and the tibia above the critical size require special attention because conventional bone grafts result in high rates of nonunion. The biological and biomechanical aspects of this challenging surgery, as well as ongoing refinements to achieve mechanically stable bone healing with correct bone alignment are reviewed. Choosing the best appropriate method is mainly dependent on both the location and etiology of the bone defect. Three patients with successful bone reconstruction using two-stage reconstruction with cancellous bone graft, double-barrel free vascularized fibula transfer and distraction osteogenesis are described. Advantages and disadvantages of these methods are discussed in accordance with recent literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Evrard, J. Role of tibial-fibular grafting in the treatment of infected pseudarthrosis of the tibia. Rev Chir Orthop Reparatrice Appar Mot 1992;78:389–98.

    PubMed  CAS  Google Scholar 

  2. Osterman, AL, Bora, FW. Free vascularized bone grafting for large-gap nonunion of long bones. Orthop Clin North Am 1984;15:131–142.

    PubMed  CAS  Google Scholar 

  3. DeCoster, TA, Gehlert, RJ, Mikola, EA, Pirela-Cruz, MA. Management of posttraumatic segmental bone defects. J Am Acad Orthop Surg 2004;12:28–38.

    PubMed  Google Scholar 

  4. Talbot, M, Zdero, R, Garneau, D, Cole, PA, Schemitsch, EH. Fixation of long bone segmental defects: a biomechanical study. Injury 2008;39:181–6.

    Article  PubMed  Google Scholar 

  5. Uhthoff, HK, Poitras, P, Backman, DS. Internal plate fixation of fractures: short history and recent developments. J Orthop Sci 2006;11:118–26.

    Article  PubMed  Google Scholar 

  6. Betz, AM, Hierner, R, Baumgart, R, Stock, W, Sebisch, E, Kettler, M, Schweiberer, L. Primary shortening-secondary lengthening. A new treatment concept for reconstruction of extensive soft tissue and bone injuries after 3rd degree open fracture and amputation of the lower leg. Handchir Mikrochir Plast Chir 1998;30:30–9.

    PubMed  CAS  Google Scholar 

  7. Pu, LL. Soft-tissue reconstruction of an open tibial wound in the distal third of the leg: a new treatment algorithm. Ann Plast Surg 2007;58:78–83.

    Article  PubMed  CAS  Google Scholar 

  8. Fischer, MD, Gustilo, RB, Varecka, TF. The timing of flap coverage, bone-grafting, and intramedullary nailing in patients who have a fracture of the tibial shaft with extensive soft-tissue injury. J Bone Joint Surg Am 1991;73:1316–22.

    PubMed  CAS  Google Scholar 

  9. Cierny G 3rd, Byrd HS, Jones RE. Primary versus delayed soft tissue coverage for severe open tibial fractures. A comparison of results. Clin Orthop Relat Res 1983;178:54–63.

    PubMed  Google Scholar 

  10. Dedmond BT, Kortesis B, Punger K, Simpson J, Argenta J, Kulp B, Morykwas M, Webb LX. The use of negative-pressure wound therapy (NPWT) in the temporary treatment of soft-tissue injuries associated with high-energy open tibial shaft fractures. J Orthop Trauma 2007;21:11–17.

    Article  PubMed  Google Scholar 

  11. Parrett BM, Matros E, Pribaz JJ, Orgill DP. Lower extremity trauma: trends in the management of soft-tissue reconstruction of open tibia-fibula fractures. Plast Reconstr Surg 2006;117:1315–1322 discussion 23-4.

    Article  PubMed  CAS  Google Scholar 

  12. Wu CC, Shih CH. Treatment of open femoral and tibial shaft fractures preliminary report on external fixation and secondary intramedullary nailing. J Formos Med Assoc 1991;90:1179–85.

    PubMed  CAS  Google Scholar 

  13. McGraw JM, Lim EV. Treatment of open tibial-shaft fractures. External fixation and secondary intramedullary nailing. J Bone Joint Surg Am 1988;70:900–911.

    PubMed  CAS  Google Scholar 

  14. Harwood PJ, Giannoudis PV, Probst C, Krettek C, Pape HC. The risk of local infective complications after damage control procedures for femoral shaft fracture. J Orthop Trauma 2006;20:181–9.

    PubMed  Google Scholar 

  15. Magyar G, Toksvig-Larsen S, Moroni A. Hydroxyapatite coating of threaded pins enhances fixation. J Bone Joint Surg Br 1997;79:487–9.

    Article  PubMed  CAS  Google Scholar 

  16. Zachee B, Roosen P, Mc Aechern AG. The dynamic axial fixator in fractures of the tibia and femur. A retrospective study in 98 patients. Acta Orthop Belg 1991;57:266–71.

    PubMed  CAS  Google Scholar 

  17. Pape HC, Hildebrand F, Pertschy S, Zelle B, Garapati R, Grimme K, Krettek C, Reed RL 2nd. Changes in the management of femoral shaft fractures in polytrauma patients: from early total care to damage control orthopedic surgery. J Trauma 2002;53:452–461, discussion 61-2.

    Article  PubMed  Google Scholar 

  18. Keating JF, Simpson AH, Robinson CM. The management of fractures with bone loss. J Bone Joint Surg Br 2005;87: 142–150.

    Article  PubMed  CAS  Google Scholar 

  19. Papineau LJ. Excision-graft with deliberately delayed closing in chronic osteomyelitis. Nouv Presse Med 1973;2:2753–5.

    PubMed  CAS  Google Scholar 

  20. Patzakis MJ, Greene N, Holtom P, Shepherd L, Bravos P, Sherman R. Culture results in open wound treatmentwith muscle transfer for tibial osteomyelitis. Clin Orthop Relat Res 1999;360:66–70.

    Article  PubMed  Google Scholar 

  21. Pelissier P, Martin D, Baudet J, Lepreux S, Masquelet AC. Behaviour of cancellous bone graft placed in induced membranes. Br J Plast Surg 2002;55:596–8.

    Article  PubMed  Google Scholar 

  22. Musharafieh R, Osmani O, Musharafieh U, Saghieh S, Atiyeh B. Efficacy of microsurgical free-tissue transfer in chronic osteomyelitis of the leg and foot: review of 22 cases. J Reconstr Microsurg 1999;15:239–244.

    Article  PubMed  CAS  Google Scholar 

  23. Weiland AJ, Phillips TW, Randolph MA. Bone grafts: a radiologic, histologic, and biomechanical model comparing autografts, allografts, and free vascularized bone grafts. Plast Reconstr Surg 1984;74:368–79.

    Article  PubMed  CAS  Google Scholar 

  24. Pelissier P, Boireau P, Martin D, Baudet J. Bone reconstruction of the lower extremity: complications and outcomes. Plast Reconstr Surg 2003;111:2223–9.

    Article  PubMed  Google Scholar 

  25. Harding AK, Aspenberg P, Kataoka M, Bylski D, Tagil M. Manipulating the anabolic and catabolic response in bone graft remodeling: synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate. J Orthop Res 2008;26:1245–9.

    Article  PubMed  Google Scholar 

  26. Little DG, Ramachandran M, Schindeler A. The anabolic and catabolic responses in bone repair. J Bone Joint Surg Br 2007;89:425–33.

    Article  PubMed  CAS  Google Scholar 

  27. Lieberman JR, Daluiski A, Einhorn TA. The role of growth factors in the repair of bone. Biology and clinical applications. J Bone Joint Surg Am 2002;84-A:1032–44.

    PubMed  Google Scholar 

  28. Novicoff WM, Manaswi A, Hogan MV, Brubaker SM, Mihalko WM, Saleh KJ. Critical analysis of the evidence for current technologies in bone-healing and repair. J Bone Joint Surg Am 2008;90:85–91.

    Article  PubMed  Google Scholar 

  29. Masquelet AC, Augereau B, Apoil A, Nordin JY. Treatment of compound fractures of the leg using pedicled or free muscle flaps and supplemental bone grafts. Rev Chir Orthop Reparatrice Appar Mot 1987;73:118–21.

    PubMed  Google Scholar 

  30. Pelissier P, Masquelet AC, Bareille R, Pelissier SM, Amedee J. Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration. J Orthop Res 2004;22:73–9.

    Article  PubMed  CAS  Google Scholar 

  31. Gazdag A, Lane J, Glaser D, Forster R. Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Surg 1995;3:1–8.

    PubMed  Google Scholar 

  32. Richards RR, Schemitsch EH. Effect of muscle flap coverage on bone blood flow following devascularization of a segment of tibia: an experimental investigation in the dog. J Orthop Res 1989;7:550–8.

    Article  PubMed  CAS  Google Scholar 

  33. Watson JT, Anders M, Moed BR. Management strategies for bone loss in tibial shaft fractures. Clin Orthop Relat Res 1995;315:138–52.

    PubMed  Google Scholar 

  34. Muramatsu K, Ihara K, Shigetomi M, Kawai S. Femoral reconstruction by single, folded or double free vascularised fibular grafts. Br J Plast Surg 2004;57:550–5.

    Article  PubMed  CAS  Google Scholar 

  35. Menezes-Leite MC, Dautel G, Duteille F, Lascombes P. Transplantation of the proximal fibula based on the anterior tibial artery. Anatomical study and clinical application. Surg Radiol Anat 2000;22:235–8.

    Article  PubMed  CAS  Google Scholar 

  36. Innocenti M, Ceruso M, Manfrini M, Angeloni R, Lauri G, Capanna R, Bufalini C. Free vascularized growth-plate transfer after bone tumor resection in children. J Reconstr Microsurg 1998;14:137–43.

    Article  PubMed  CAS  Google Scholar 

  37. Innocenti M, Delcroix L, Romano GF. Epiphyseal transplant: harvesting technique of the proximal fibula based on the anterior tibial artery. Microsurgery 2005;25:284–92.

    Article  PubMed  Google Scholar 

  38. Pelissier P, Casoli V, Demiri E, Martin D, Baudet J. Soleus-fibula free transfer in lower limb reconstruction. Plast Reconstr Surg 2000;105:567–73.

    Article  PubMed  CAS  Google Scholar 

  39. Lin CH, Wei FC, Lin YT, Yeh JT, Rodriguez Ede J, Chen CT. Lateral circumflex femoral artery system: warehouse for functional composite free-tissue reconstruction of the lower leg. J Trauma 2006;60:1032–6.

    Article  PubMed  Google Scholar 

  40. Weiland AJ. Vascularized bone transfers. Instr Course Lect 1984;33:446–60.

    PubMed  CAS  Google Scholar 

  41. Yazar S, Lin CH, Wei FC. One-stage reconstruction of composite bone and soft-tissue defects in traumatic lower extremities. Plast Reconstr Surg 2004;114:1457–66.

    Article  PubMed  Google Scholar 

  42. Aronson J. Limb-lengthening, skeletal reconstruction, and bone transport with the Ilizarov method. J Bone Joint Surg Am 1997;79:1243–58.

    PubMed  CAS  Google Scholar 

  43. Dahl MT, Gulli B, Berg T. Complications of limb lengthening. A learning curve. Clin Orthop Relat Res 1994;301:10–8.

    PubMed  Google Scholar 

  44. Green SA, Harris NL, Wall DM, Ishkanian J, Marinow H. The Rancho mounting technique for the Ilizarov method. A preliminary report. Clin Orthop Relat Res 1992;280:104–16.

    PubMed  Google Scholar 

  45. Aldegheri R. Distraction osteogenesis for lengthening of the tibia in patients who have limb-length discrepancy or short stature. J Bone Joint Surg Am 1999;81:624–34.

    PubMed  CAS  Google Scholar 

  46. Hofmann GO, Gonschorek O, Buhren V. Segment transport employing intramedullary devices in tibial bone defects following trauma and infection. J Orthop Trauma 1999;13:170–7.

    Article  PubMed  CAS  Google Scholar 

  47. Knothe Tate ML, Ritzman TF, Schneider E, Knothe UR. Testing of a new one-stage bone-transport surgical procedure exploiting the periosteum for the repair of long-bone defects. J Bone Joint Surg Am 2007;89:307–16.

    Article  PubMed  Google Scholar 

  48. McKee MD, Yoo DJ, Zdero R, Dupere M, Wild L, Schemitsch EH, Mahoney J. Combined single-stage osseous and soft tissue reconstruction of the tibia with the Ilizarov method and tissue transfer. J Orthop Trauma 2008;22:183–9.

    Article  PubMed  Google Scholar 

  49. Musharafieh RS, Saghieh SS, Nassar H, Hamdan AM, Hashim HA, Atiyeh BS. Microvascular soft-tissue coverage and distraction osteosynthesis for lower-extremity salvage. Microsurgery 1996;17:666–73.

    Article  PubMed  CAS  Google Scholar 

  50. Ring D, Jupiter JB, Gan BS, Israeli R, Yaremchuk MJ. Infected nonunion of the tibia. Clin Orthop Relat Res 1999;369:302–11.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Charles E. Dumont MD, PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dumont, C.E., Exner, U.G. Reconstruction of Large Diaphyseal Defects of the Femur and the Tibia with Autologous Bone. Eur J Trauma Emerg Surg 35, 17–25 (2009). https://doi.org/10.1007/s00068-008-8224-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00068-008-8224-4

Key Words

Navigation