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Update zur kombinierten Radio-, Radiochemo- und alleinigen Chemotherapie bei der multimodalen Therapie des Nasopharynxkarzinoms – eine MAC-NPC-Metaanalyse

Update on combined radio-, radiochemo-, and chemotherapy alone in multimodal therapy of nasopharyngeal carcinoma—a MAC-NPC meta-analysis

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Literatur

  1. Al-sarraf BM, Leblanc M, Giri PS et al (1998) Chemoradiotherpy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup Study 0099. J Clin Oncol 16:1310–1317

    CAS  PubMed  Google Scholar 

  2. Baujat B, Audry H, Bourhis J et al (2006) Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys 64:47–56

    Article  CAS  PubMed  Google Scholar 

  3. Loong HH, Ma BB, Leung SF et al (2012) Prognostic significance of the total dose of cisplatin administered during concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. Radiother Oncol 104:300–304

    Article  CAS  PubMed  Google Scholar 

  4. Langendijk JA, Leemans CR, Buter J et al (2004) The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature. J Clin Oncol 22:4604–4612

    Article  CAS  PubMed  Google Scholar 

  5. Wu X, Huang PY, Peng PJ et al (2013) Long-term follow-up of a phase III study comparing radiotherapy with or without weekly oxaliplatin for locoregionally advanced nasopharyngeal carcinoma. Ann Oncol 24:2131O2136. doi:10.1093/annonc/mdt163 (Epub 2013 May 9)

    Google Scholar 

  6. Kwong DL, Sham JS, Au GK et al (2004) Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study. J Clin Oncol 22:2643–2653

    Article  CAS  PubMed  Google Scholar 

  7. Lee AWM, Tung SY, Ngan RKC et al (2011) Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials. Eur J Cancer 47:656–666

    Article  CAS  PubMed  Google Scholar 

  8. Lee AW, Ngan RK, Tung SY et al (2015) Preliminary results of trial NPC- 0501 evaluating the therapeutic gain by changing from concurrent adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fractionation in patients with locoregionally advanced nasopharyngeal carcinoma. Cancer 121:1328–1338

    Article  CAS  PubMed  Google Scholar 

  9. National Comprehensive Cancer Network guidelines (2014) http://www.nccn.org/professionals/physician_gls/pdf. Zugegriffen: 23. Apr. 2015

  10. Mertens R, Granzen B, Lassay L et al (2005) Treatment of nasopharyngeal carcinoma in children and adolescents: definitive results of a multicenter study (NPC-91-GPOH). Cancer 104:1083–1089

    Article  PubMed  Google Scholar 

  11. Buehrlen M, Zwaan CM, Granzen B et al (2012) Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults: preliminary results from the prospective, multicenter study NPC-2003-GPOH/DCOG. Cancer 118:4892–4900

    Article  CAS  PubMed  Google Scholar 

  12. Wolff A, Rödel RM, Gunawan B et al (2010) Nasopharyngeal carcinoma in adults: treatment results after long-term follow-up with special reference to adjuvant interferon-beta in undifferentiated carcinomas. J Cancer Res Clin Oncol 136:89–97

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. NPC-2014-GPOH-Register – Multizentrisches Register zur Behandlung des EBV-assoziierten Nasopharynxkarzinoms bei Kindern und Jugendlichen

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Correspondence to Martina Becker-Schiebe.

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M. Becker-Schiebe und H. Christiansen geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Originalpublikation

Blanchard P, Lee A, Marguet S et al on behalf of the MAC-NPC Collaborative Group (2015) Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis. Lancet Oncol 16:645–655

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Becker-Schiebe, M., Christiansen, H. Update zur kombinierten Radio-, Radiochemo- und alleinigen Chemotherapie bei der multimodalen Therapie des Nasopharynxkarzinoms – eine MAC-NPC-Metaanalyse. Strahlenther Onkol 191, 991–993 (2015). https://doi.org/10.1007/s00066-015-0904-5

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  • DOI: https://doi.org/10.1007/s00066-015-0904-5

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