Zusammenfassung
Dermale und inhalative Vergiftungen, die eine intensivmedizinische Behandlung bedingen, kommen im Alltag nur sehr selten vor. Daher besteht bei den meisten Ärzten hier auch keine hohe Behandlungserfahrung und -Routine. In der vorliegenden Arbeit soll die intensivmedizinische Behandlung von dermalen Verätzungen mit Flusssäure inkl. der vorgeschalteten Diagnostik spezifisch toxikologisch besprochen werden. Bei den inhalativen Vergiftungen werden aus dem Kreis der Brandgase die Expositionen gegenüber Zyaniden und Kohlenmonoxid (CO) behandelt. Besonderes Augenmerk wird auf die hyperbare Sauerstofftherapie bei CO-Vergiftungen gelegt.
Abstract
Patients with dermal and inhalation poisoning are uncommon in intensive care treatment. We describe the diagnostics and specific toxicological treatment of patients with hydrofluoric acid burns. For inhalation poisoning, we focus on smoke inhalation, especially the management of cyanide and carbon monoxide poisoning. Special attention is given to the use of hyperbaric oxygenation for the treatment of carbon monoxide poisoning.
Literatur
Mullett T, Zoeller T, Bingham H et al (1987) Fatal hydrofluoric acid cutaneous exposure with refractory ventricular fibrillation. J Burn Care Rehabil 8(3):216–219
Chan KM, Svancarek WP, Creer M (1987) Fatality due to acute hydrofluoric acid exposure. J Toxicol Clin Toxicol 25(4):333–339
McIvor ME, Cummings CE, Mower MM et al (1987) Sudden cardiac death from acute fluoride intoxication: the role of potassium. Ann Emerg Med 16(7):777–781
Wedler V, Guggenheim M, Moron M et al (2005) Extensive hydrofluoric acid injuries: a serious problem. J Trauma 58(4):852–857
Stuke LE, Arnoldo BD, Hunt JL, Purdue GF (2008) Hydrofluoric acid burns: a 15-year experience. J Burn Care Res 29(6):893–896
Ozcan M, Allahbeickaraghi A, Dündar M (2012) Possible hazardous effects of hydrofluoric acid and recommendations for treatment approach: a review. Clin Oral Investig 16(1):15–23
Hultén P, Höjer J, Ludwigs U, Janson A (2004) Hexafluorine vs. standard decontamination to reduce systemic toxicity after dermal exposure to hydrofluoric acid. J Toxicol Clin Toxicol 42(4):355–361
Thomas D, Jaeger U, Sagoschen I et al (2009) Intra-arterial calcium gluconate treatment after hydrofluoric acid burn of the hand. Cardiovasc Intervent Radiol 32(1):155–158
Antar-Shultz M, Rifkin SI, McFarren C (2011) Use of hemodialysis after ingestion of a mixture of acids containing hydrofluoric acid. Int J Clin Pharmacol Ther 49(11):695–699
Björnhagen V, Höjer J, Karlson-Stiber C et al (2003) Hydrofluoric acid-induced burns and life-threatening systemic poisoning – favorable outcome after hemodialysis. J Toxicol Clin Toxicol 41(6):855–860
Clark WR, Nieman GF (1988) Smoke inhalation. Burns 14(6):473–494
Siemers F, Mailänder P (2010) Inhalationstrauma, Kohlenmonoxid-und Cyanidintoxikation. Notfall Rettungsmed 13(1):17–22
Hoppe U, Klose R (2005) Das Inhalationstrauma bei Verbrennungspatienten: Diagnostik und Therapie. Med Klin Intensivmed Notfmed 42:425–439
Herndon DN, Barrow RE, Traber DL et al (1987) Extravascular lung water changes following smoke inhalation and massive burn injury. Surgery 102(2):341–349
Heimbach DM, Waeckerle JF (1988) Inhalation injuries. Ann Emerg Med 17(12):1316–1320
Uhl W, Nolting A, Golor G et al (2006) Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 44(Suppl 1):17–28
O’Brien DJ, Walsh DW, Terriff CM, Hall AH (2011) Empiric management of cyanide toxicity associated with smoke inhalation. Prehosp Disaster Med 374–382
Hall AH, Saiers J, Baud F (2009) Which cyanide antidote? Crit Rev Toxicol 39(7):541–552
Weaver LK (2009) Clinical practice. Carbon monoxide poisoning. N Engl J Med 360(12):1217–1225
Hampson NB, Hampson LA (2002) Characteristics of headache associated with acute carbon monoxide poisoning. Headache 42(3):220–223
Simini B (1998) Cherry-red discolouration in carbon monoxide poisoning. Lancet 352(9134):1154
Gorman DF, Clayton D, Gilligan JE, Webb RK (1992) A longitudinal study of 100 consecutive admissions for carbon monoxide poisoning to the Royal Adelaide Hospital. Anaesth Intensive Care 20(3):311–316
Weaver LK (1999) Carbon monoxide poisoning. Crit Care Clin 15(2):297–317–viii
Roth D, Herkner H, Schreiber W et al (2011) Accuracy of noninvasive multiwave pulse oximetry compared with carboxyhemoglobin from blood gas analysis in unselected emergency department patients. Ann Emerg Med 58(1):74–79
Thom SR, Taber RL, Mendiguren II et al (1995) Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med 25(4):474–480
Annane D, Chadda K, Gajdos P et al (2011) Hyperbaric oxygen therapy for acute domestic carbon monoxide poisoning: two randomized controlled trials. Intensive Care Med 37(3):486–492
Hampson NB, Hauff NM (2008) Carboxyhemoglobin levels in carbon monoxide poisoning: do they correlate with the clinical picture? Am J Emerg Med 26(6):665–669
Hampson NB, Piantadosi CA, Thom SR, Weaver LK (2012) Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning. Am J Respir Crit Care Med 186(11):1095–1101
Buckley NA, Juurlink DN, Isbister G et al (2011) Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev (Online) 4:CD002041
Hampson NB, Dunford RG, Ross DE, Wreford-Brown CE (2006) A prospective, randomized clinical trial comparing two hyperbaric treatment protocols for carbon monoxide poisoning. Undersea Hyperb Med 33(1):27–32
Weaver LK, Hopkins RO, Chan KJ et al (2002) Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 347(14):1057–1067
Scheinkestel CD, Bailey M, Myles PS et al (1999) Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning: a randomised controlled clinical trial. Med J Aust 170(5):203–210
Raphael JC, Elkharrat D, Jars-Guincestre MC et al (1989) Trial of normobaric and hyperbaric oxygen for acute carbon monoxide intoxication. Lancet 2(8660):414–419
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Interessenkonflikt. I. Sagoschen gibt an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
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Sagoschen, I. Dermale und inhalative Intoxikationen. Med Klin Intensivmed Notfmed 108, 476–483 (2013). https://doi.org/10.1007/s00063-013-0220-8
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DOI: https://doi.org/10.1007/s00063-013-0220-8