Abstract
Background
A growing number of studies have suggested that the single nucleotide polymorphism (SNP) rs662 (G>A) in paraoxonase 1 (PON1) is significantly associated with susceptibility to coronary heart disease (CHD) in the Chinese population. To further evaluate the effects of the PON1 RS662 (G>A) polymorphism on the risk of CHD, we performed a meta-analysis in a Chinese population.
Methods
PubMed, Embase, Wanfang Data, Chinese National Knowledge Infrastructure (CNKI) were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations between RS662 (G>A) and CHD.
Result
In the meta-analysis, we identified 14 articles, including a total of 4835 CHD patients and 5111 controls in the Chinese population. Our result showed that overall rs662 (G>A) was significantly associated with susceptibility to CHD in the Chinese population when compared with healthy controls. Furthermore, a G allele suggested an elevated risk of CHD. In the subgroup analyses stratified by ethnicity and geographic areas, significant associations were found in Chinese Han and South China, but not in North China.
Conclusion
The present meta-analysis suggests that rs662 (G>A) SNP in PON1 is associated with CHD risk; the G allele might be the risk allele for CHD susceptibility in the Chinese population. However, more research is required to make a definite conclusion.
Zusammenfassung
Hintergrund
Immer mehr Studien liefern Belege, dass der Einzelnukleotidpolymorphismus („single nucleotide polymorphism“ [SNP]) rs662 (G>A) in der Paraoxonase 1 (PON1) signifikant mit der Anfälligkeit für die koronare Herzkrankheit (KHK) in der chinesischen Bevölkerung assoziiert ist. Zur genaueren Untersuchung der Effekte des PON1-rs662-(G>A)-Polymorphismus auf das KHK-Risiko wurde eine Metaanalyse mit chinesischen Populationen durchgeführt.
Methoden
PubMed, Embase, Wanfang Data und Chinese National Knowledge Infrastructure (CNKI) wurden nach relevanten Studien durchsucht. Mit gepoolten Odds Ratios (OR) und 95 %-Konfidenzintervallen (KI) wurde die Stärke der Assoziationen zwischen RS662 (G>A) und KHK untersucht.
Ergebnisse
In der Metaanalyse wurden 14 Beiträge mit insgesamt 4835 KHK-Patienten und 5111 Kontrollen aus der chinesischen Bevölkerung identifiziert. Die Analyse ergab im Vergleich mit gesunden Kontrollen, dass rs662 (G>A) insgesamt signifikant mit der KHK-Anfälligkeit in der chinesischen Bevölkerung assoziiert war. Darüber hinaus wies ein G‑Allel auf ein erhöhtes KHK-Risiko hin. In der Subgruppenanalyse mit Stratifizierung nach ethnischer Zugehörigkeit und geografischer Region wurden signifikante Assoziationen bei Han-Chinesen gefunden, ebenso in Südchina, nicht jedoch in Nordchina.
Schlussfolgerung
Gemäß der vorliegenden Metaanalyse ist der rs662-(G>A)-SNP in PON1 mit dem KHK-Risiko assoziiert; das G‑Allel könnte das Risikoallel für KHK-Anfälligkeit in der chinesischen Bevölkerung sein. Eine endgültige Beurteilung setzt allerdings weitere Forschungsbemühungen voraus.
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Abbreviations
- CHD:
-
Coronary heart disease
- CI:
-
Confidence intervals
- CNKI:
-
China National Knowledge Infrastructure
- HWE:
-
Hardy–Weinberg equilibrium
- ORs:
-
Pooled odds ratios
- PON1:
-
Paraoxonase 1
- SNP:
-
Single nucleotide polymorphism
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Acknowledgements
We gratefully acknowledge the Yichang Key Laboratory of ischemic cardiovascular and cerebrovascular disease translational medicine foundation (2017KXN09) for generous financial support.
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Z. Deng, H. Xiang and W. Gao declare that they have no competing interests.
This article does not contain any studies with human participants or animals performed by any of the authors.
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Deng, Z., Xiang, H. & Gao, W. Significant association between paraoxonase 1 rs662 polymorphism and coronary heart disease. Herz 45, 347–355 (2020). https://doi.org/10.1007/s00059-018-4737-8
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DOI: https://doi.org/10.1007/s00059-018-4737-8