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Assessment of arterial stiffness in chronic obstructive pulmonary disease by a novel method

Cardio-ankle vascular index

Beurteilung der arteriellen Steifigkeit bei chronisch obstruktiver Lungenerkrankung anhand einer neuen Methode

Herz-Knöchel-Gefäßindex

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Abstract

Background

Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of cardiovascular morbidity and mortality. Increased arterial stiffness is associated with the presence and severity of cardiovascular disease. The cardio-ankle vascular index (CAVI) is a new method for assessment of arterial stiffness that is not influenced by blood pressure at the time of measurement and is significantly correlated with the presence and severity of cardiovascular disease. The aim of the present study was to evaluate whether there is an association between the spirometric severity of COPD, according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, with arterial stiffness as assessed by CAVI.

Methods

We enrolled 123 patients with COPD (102 men) followed up by the chest medicine outpatient clinics and 35 healthy subjects (26 men). All patients were assessed with spirometry, CAVI, and clinical history.

Results

Patients with COPD had significantly increased CAVI values compared with control subjects (10.37 ± 2.26 vs. 6.74 ± 1.42, p < 0.001). CAVI was correlated with FEV1 % predicted, FEV1/FVC, and COPD stage (r: − 0.54, p < 0.001; r: − 0.58, p < 0.001 and r: 0.78, p < 0.001, respectively). Multivariate regression analysis showed that CAVI was independently associated with GOLD stages (p < 0.001).

Conclusion

In this study, we have shown that increased arterial stiffness assessed by CAVI is associated with the spirometric severity of COPD.

Zusammenfassung

Hintergrund

Patienten mit chronisch obstruktiver Lungenerkrankung (COPD) weisen ein erhöhtes Risiko kardiovaskulärer Morbidität und Mortalität auf. Erhöhte arterielle Steifigkeit steht mit dem Vorliegen und dem Schweregrad kardiovaskulärer Erkrankungen in Zusammenhang. Der Herz-Knöchel-Gefäßindex („cardio-ankle vascular index“, CAVI) ist eine neue Methode zur Beurteilung der arteriellen Steifigkeit, welche nicht durch den Blutdruck zum Zeitpunkt der Messung beeinflusst wird und die signifikant mit dem Bestehen und der Schwere von Herz-Kreislauf-Erkrankungen korreliert ist. Ziel der vorliegenden Studie war zu untersuchen, ob ein Zusammenhang zwischen dem spirometrischen Schweregrad der COPD gemäß den Kriterien der Global Initiative for Chronic Obstructive Lung Disease (GOLD) und der arteriellen Steifigkeit gemäß CAVI-Untersuchung besteht.

Methoden

In die Studie wurden 123 Patienten (102 Männer) mit COPD aufgenommen, welche ambulant durch die pulmologische Klinik versorgt wurden, und 35 gesunde Teilnehmer (26 Männer). Bei allen Patienten erfolgten Spirometrie, CAVI und klinische Anamneseerhebung.

Ergebnisse

Bei Patienten mit COPD sind die CAVI-Werte gegenüber den Kontrollen signifikant erhöht (10,37 ± 2,26 vs. 6,74 ± 1,42; p < 0,001). Der CAVI war mit dem vorhergesagten FEV1 %, FEV1/FVC und dem COPD-Stadium korreliert (r: − 0,54; p < 0,001; r: − 0,58; p < 0,001 bzw. r: 0,78; p < 0,001). Die multivariate Regressionsanalyse zeigte, das der CAVI unabhängig mit den GOLD-Stadien assoziiert war (p < 0,001).

Schlussfolgerung

In dieser Studie wurde gezeigt, dass eine erhöhte arterielle Steifigkeit in der CAVI-Untersuchung mit dem spirometrisch erhobenen Schweregrad der COPD assoziiert ist.

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Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.

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Authors and Affiliations

  1. Department of Cardiology, Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Soğuksu Mahallesi, Çamlık Caddesi, 61040, Trabzon, Turkey

    A.Ç. Aykan, T. Gökdeniz, F. Boyacı, İ Gül, E. Hatem, E. Kalaycıoğlu, T. Turan & H. Bektaş

  2. Department of Respiratory Medicine, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey

    M.B. Çilingir, F. Ayyıldız & S. Altun

  3. Department of Pharmacology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey

    D.A. Aykan

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  1. A.Ç. Aykan
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  2. T. Gökdeniz
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  3. F. Boyacı
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  4. İ Gül
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  6. E. Kalaycıoğlu
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  7. T. Turan
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  8. H. Bektaş
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  9. M.B. Çilingir
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  10. D.A. Aykan
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  11. F. Ayyıldız
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  12. S. Altun
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Correspondence to A.Ç. Aykan.

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Aykan, A., Gökdeniz, T., Boyacı, F. et al. Assessment of arterial stiffness in chronic obstructive pulmonary disease by a novel method. Herz 39, 822–827 (2014). https://doi.org/10.1007/s00059-013-3902-3

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  • DOI: https://doi.org/10.1007/s00059-013-3902-3

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