Abstract
A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate class engrafted by an enaminone group. The anticancer and antimicrobial activities were evaluated by utilizing three different types of human cancer (MDA-MB-231, LoVo, and HepG2) and a wide field of microbes (G+ and G− bacteria, yeast, and molds). The tested compound 3 exhibited moderate growth suppression activity versus all examined human tumor cells, with values of IC50 ranging from 35 to 45 µg/ml. Moreover, the antimicrobial effects of compound 3 were more profound against fungal pathogens than against bacterial pathogens (minimal inhibitory concentrations; fungi, 0.08–0.14 mg/ml; bacteria, 0.3–1.4 mg/ml). These findings lay the foundation for designing improved bioactive agents that could be utilized as anticancer and/or antimicrobial agents.
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The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this research (R. G. P. 2/83/41).
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Prof. Yahia N. Mabkhot holds a patent on the use of this compound [US 10,071,960 B1]. Other authors declare no conflict of interest.
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Mabkhot, Y.N., Khaled, J.M.A., Sultan, M.A.S. et al. Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent. Med Chem Res 29, 954–961 (2020). https://doi.org/10.1007/s00044-020-02535-2
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DOI: https://doi.org/10.1007/s00044-020-02535-2