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Phytochemical characterization and biological activity of secondary metabolites from three Limonium species

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Abstract

The comparative phytochemical constituents of three Limonium species Limonium myrianthum, Limonium leptophyllum, and Limonium gmelinii afforded a new compound (2R,3S)-2,3,4-trihydroxy-2-methylbutyl gallate (1) and twenty known compounds (2–21). Each species displayed different profiles in their phytochemical constituents. The isolated compounds (1–21) were evaluated for antifungal, antimalarial, and antitrypanosomal activities. Compound 1 showed good activity against chloroquine-resistant and chloroquine-sensitive strains of malaria, while compound 5 displayed moderate antimalarial activity. Compound 14 showed a significant activity against Trypanosoma brucei.

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Acknowledgements

We are grateful to the Government of the Republic of Kazakhstan and the National Center for Natural Products Research (NCNPR), University of Mississippi, School of Pharmacy, USA for financial support. Also we are grateful to Dr. Melissa Jacob, Dr. Shabana Khan, and Dr. Babu Tekwani for performing antibacterial, antifungal, antimalarial, and antileishmanial bioassays.

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Authors and Affiliations

  1. National Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA

    Anastassiya V. Gadetskaya, Shaymaa M. Mohamed, Nesma M. Mohamed, Guoyi Ma & Samir A. Ross

  2. School of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan

    Anastassiya V. Gadetskaya & Galiya E. Zhusupova

  3. Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

    Shaymaa M. Mohamed & Nesma M. Mohamed

  4. Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA

    Amer H. Tarawneh, Stephen J. Cutler & Samir A. Ross

  5. Department of Chemistry, Tafila Technical University, P.O. Box 179, Tafila, Jordan

    Amer H. Tarawneh

  6. Institute of Plant Biology and Biotechnology, Almaty, Kazakhstan

    Boris N. Ponomarev

  7. Natural Products Utilization Research Unit, USDA-ARS, University, MS, 38677, USA

    Charles L. Cantrell

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  1. Anastassiya V. Gadetskaya
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  2. Shaymaa M. Mohamed
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  3. Amer H. Tarawneh
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  4. Nesma M. Mohamed
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  5. Guoyi Ma
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  6. Boris N. Ponomarev
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  7. Galiya E. Zhusupova
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  8. Charles L. Cantrell
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  9. Stephen J. Cutler
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  10. Samir A. Ross
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Correspondence to Samir A. Ross.

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Gadetskaya, A.V., Mohamed, S.M., Tarawneh, A.H. et al. Phytochemical characterization and biological activity of secondary metabolites from three Limonium species. Med Chem Res 26, 2743–2750 (2017). https://doi.org/10.1007/s00044-017-1973-z

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  • DOI: https://doi.org/10.1007/s00044-017-1973-z

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