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Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins

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Abstract

The cytotoxic and cancer preventive activities of synthetic analogs of natural varacins with polysulfide groups were studied. Presence of a sulfoxide group was found to have no significant effect on the cytotoxicity of these compounds. At the same time, this group is important for inhibition of colony formation of tumor cells treated with tumor promoter thus demonstrating cancer preventive activity. The most promising compound appears to be a synthetic varacin C analog, sulfoxide 10a, which exhibits the cancer preventive activity at dose into 100 times lower than its cytotoxic concentrations.

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Authors and Affiliations

  1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, Vladivostok, 690022, Russia

    Alexandra S. Kuzmich, Sergey N. Fedorov, Tatyana N. Makarieva & Larisa K. Shubina

  2. Novosibirsk Institute of Organic Chemistry, pr. Lavrentieva, 9, Novosibirsk, 630090, Russia

    Tatyana M. Khomenko, Nina I. Komarova, Dina V. Korchagina, Tatyana V. Rybalova, Konstantin P. Volcho & Nariman F. Salakhutdinov

  3. Novosibirsk State University, Pirogova 2, Novosibirsk, 630090, Russia

    Tatyana M. Khomenko, Konstantin P. Volcho & Nariman F. Salakhutdinov

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  1. Alexandra S. Kuzmich
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  2. Tatyana M. Khomenko
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  3. Sergey N. Fedorov
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  4. Tatyana N. Makarieva
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  5. Larisa K. Shubina
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  6. Nina I. Komarova
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  7. Dina V. Korchagina
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  8. Tatyana V. Rybalova
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  9. Konstantin P. Volcho
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  10. Nariman F. Salakhutdinov
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Correspondence to Konstantin P. Volcho.

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Kuzmich, A.S., Khomenko, T.M., Fedorov, S.N. et al. Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins. Med Chem Res 26, 397–404 (2017). https://doi.org/10.1007/s00044-016-1759-8

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